Showing 200 of total 682 results (show query)

projectmosaic

ggformula:Formula Interface to the Grammar of Graphics

Provides a formula interface to 'ggplot2' graphics.

Maintained by Randall Pruim. Last updated 1 years ago.

38 stars 11.55 score 1.7k scripts 25 dependents

john-d-fox

Rcmdr:R Commander

A platform-independent basic-statistics GUI (graphical user interface) for R, based on the tcltk package.

Maintained by John Fox. Last updated 5 months ago.

4 stars 9.48 score 636 scripts 38 dependents

atorus-research

xportr:Utilities to Output CDISC SDTM/ADaM XPT Files

Tools to build CDISC compliant data sets and check for CDISC compliance.

Maintained by Eli Miller. Last updated 3 months ago.

clinical-programmersxpt

43 stars 8.84 score 102 scripts

eltebioinformatics

mulea:Enrichment Analysis Using Multiple Ontologies and False Discovery Rate

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

Maintained by Tamas Stirling. Last updated 4 months ago.

annotationdifferentialexpressiongeneexpressiongenesetenrichmentgographandnetworkmultiplecomparisonpathwaysreactomesoftwaretranscriptionvisualizationenrichmentenrichment-analysisfunctional-enrichment-analysisgene-set-enrichmentontologiestranscriptomicscpp

28 stars 7.36 score 34 scripts

mwheymans

psfmi:Prediction Model Pooling, Selection and Performance Evaluation Across Multiply Imputed Datasets

Pooling, backward and forward selection of linear, logistic and Cox regression models in multiply imputed datasets. Backward and forward selection can be done from the pooled model using Rubin's Rules (RR), the D1, D2, D3, D4 and the median p-values method. This is also possible for Mixed models. The models can contain continuous, dichotomous, categorical and restricted cubic spline predictors and interaction terms between all these type of predictors. The stability of the models can be evaluated using (cluster) bootstrapping. The package further contains functions to pool model performance measures as ROC/AUC, Reclassification, R-squared, scaled Brier score, H&L test and calibration plots for logistic regression models. Internal validation can be done across multiply imputed datasets with cross-validation or bootstrapping. The adjusted intercept after shrinkage of pooled regression coefficients can be obtained. Backward and forward selection as part of internal validation is possible. A function to externally validate logistic prediction models in multiple imputed datasets is available and a function to compare models. For Cox models a strata variable can be included. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>.

Maintained by Martijn Heymans. Last updated 2 years ago.

cox-regressionimputationimputed-datasetslogisticmultiple-imputationpoolpredictorregressionselectionsplinespline-predictors

10 stars 7.17 score 70 scripts

huanglabumn

oncoPredict:Drug Response Modeling and Biomarker Discovery

Allows for building drug response models using screening data between bulk RNA-Seq and a drug response metric and two additional tools for biomarker discovery that have been developed by the Huang Laboratory at University of Minnesota. There are 3 main functions within this package. (1) calcPhenotype is used to build drug response models on RNA-Seq data and impute them on any other RNA-Seq dataset given to the model. (2) GLDS is used to calculate the general level of drug sensitivity, which can improve biomarker discovery. (3) IDWAS can take the results from calcPhenotype and link the imputed response back to available genomic (mutation and CNV alterations) to identify biomarkers. Each of these functions comes from a paper from the Huang research laboratory. Below gives the relevant paper for each function. calcPhenotype - Geeleher et al, Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. GLDS - Geeleher et al, Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models. IDWAS - Geeleher et al, Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies.

Maintained by Robert Gruener. Last updated 12 months ago.

svapreprocesscorestringrbiomartgenefilterorg.hs.eg.dbgenomicfeaturestxdb.hsapiens.ucsc.hg19.knowngenetcgabiolinksbiocgenericsgenomicrangesirangess4vectors

18 stars 6.47 score 41 scripts

bioc

SCOPE:A normalization and copy number estimation method for single-cell DNA sequencing

Whole genome single-cell DNA sequencing (scDNA-seq) enables characterization of copy number profiles at the cellular level. This circumvents the averaging effects associated with bulk-tissue sequencing and has increased resolution yet decreased ambiguity in deconvolving cancer subclones and elucidating cancer evolutionary history. ScDNA-seq data is, however, sparse, noisy, and highly variable even within a homogeneous cell population, due to the biases and artifacts that are introduced during the library preparation and sequencing procedure. Here, we propose SCOPE, a normalization and copy number estimation method for scDNA-seq data. The distinguishing features of SCOPE include: (i) utilization of cell-specific Gini coefficients for quality controls and for identification of normal/diploid cells, which are further used as negative control samples in a Poisson latent factor model for normalization; (ii) modeling of GC content bias using an expectation-maximization algorithm embedded in the Poisson generalized linear models, which accounts for the different copy number states along the genome; (iii) a cross-sample iterative segmentation procedure to identify breakpoints that are shared across cells from the same genetic background.

Maintained by Rujin Wang. Last updated 5 months ago.

singlecellnormalizationcopynumbervariationsequencingwholegenomecoveragealignmentqualitycontroldataimportdnaseq

5.92 score 84 scripts

tirgit

missCompare:Intuitive Missing Data Imputation Framework

Offers a convenient pipeline to test and compare various missing data imputation algorithms on simulated and real data. These include simpler methods, such as mean and median imputation and random replacement, but also include more sophisticated algorithms already implemented in popular R packages, such as 'mi', described by Su et al. (2011) <doi:10.18637/jss.v045.i02>; 'mice', described by van Buuren and Groothuis-Oudshoorn (2011) <doi:10.18637/jss.v045.i03>; 'missForest', described by Stekhoven and Buhlmann (2012) <doi:10.1093/bioinformatics/btr597>; 'missMDA', described by Josse and Husson (2016) <doi:10.18637/jss.v070.i01>; and 'pcaMethods', described by Stacklies et al. (2007) <doi:10.1093/bioinformatics/btm069>. The central assumption behind 'missCompare' is that structurally different datasets (e.g. larger datasets with a large number of correlated variables vs. smaller datasets with non correlated variables) will benefit differently from different missing data imputation algorithms. 'missCompare' takes measurements of your dataset and sets up a sandbox to try a curated list of standard and sophisticated missing data imputation algorithms and compares them assuming custom missingness patterns. 'missCompare' will also impute your real-life dataset for you after the selection of the best performing algorithm in the simulations. The package also provides various post-imputation diagnostics and visualizations to help you assess imputation performance.

Maintained by Tibor V. Varga. Last updated 4 years ago.

comparisoncomparison-benchmarksimputationimputation-algorithmimputation-methodsimputationskolmogorov-smirnovmissingmissing-datamissing-data-imputationmissing-status-checkmissing-valuesmissingnesspost-imputation-diagnosticsrmse

39 stars 5.89 score 40 scripts

insightsengineering

osprey:R Package to Create TLGs

Community effort to collect TLG code and create a catalogue.

Maintained by Nina Qi. Last updated 1 months ago.

cataloggraphslistingsnesttables

4 stars 5.38 score 1 dependents