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bioc
genefilter:genefilter: methods for filtering genes from high-throughput experiments
Some basic functions for filtering genes.
Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.
62.1 match 11.10 score 2.4k scripts 142 dependents
huanglabumn
oncoPredict:Drug Response Modeling and Biomarker Discovery
Allows for building drug response models using screening data between bulk RNA-Seq and a drug response metric and two additional tools for biomarker discovery that have been developed by the Huang Laboratory at University of Minnesota. There are 3 main functions within this package. (1) calcPhenotype is used to build drug response models on RNA-Seq data and impute them on any other RNA-Seq dataset given to the model. (2) GLDS is used to calculate the general level of drug sensitivity, which can improve biomarker discovery. (3) IDWAS can take the results from calcPhenotype and link the imputed response back to available genomic (mutation and CNV alterations) to identify biomarkers. Each of these functions comes from a paper from the Huang research laboratory. Below gives the relevant paper for each function. calcPhenotype - Geeleher et al, Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. GLDS - Geeleher et al, Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models. IDWAS - Geeleher et al, Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies.
Maintained by Robert Gruener. Last updated 12 months ago.
svapreprocesscorestringrbiomartgenefilterorg.hs.eg.dbgenomicfeaturestxdb.hsapiens.ucsc.hg19.knowngenetcgabiolinksbiocgenericsgenomicrangesirangess4vectors
10.0 match 18 stars 6.47 score 41 scriptsbioc
CNTools:Convert segment data into a region by sample matrix to allow for other high level computational analyses.
This package provides tools to convert the output of segmentation analysis using DNAcopy to a matrix structure with overlapping segments as rows and samples as columns so that other computational analyses can be applied to segmented data
Maintained by J. Zhang. Last updated 5 months ago.
3.0 match 5.30 score 33 scripts 1 dependents