Showing 99 of total 99 results (show query)

bioc

BASiCS:Bayesian Analysis of Single-Cell Sequencing data

Single-cell mRNA sequencing can uncover novel cell-to-cell heterogeneity in gene expression levels in seemingly homogeneous populations of cells. However, these experiments are prone to high levels of technical noise, creating new challenges for identifying genes that show genuine heterogeneous expression within the population of cells under study. BASiCS (Bayesian Analysis of Single-Cell Sequencing data) is an integrated Bayesian hierarchical model to perform statistical analyses of single-cell RNA sequencing datasets in the context of supervised experiments (where the groups of cells of interest are known a priori, e.g. experimental conditions or cell types). BASiCS performs built-in data normalisation (global scaling) and technical noise quantification (based on spike-in genes). BASiCS provides an intuitive detection criterion for highly (or lowly) variable genes within a single group of cells. Additionally, BASiCS can compare gene expression patterns between two or more pre-specified groups of cells. Unlike traditional differential expression tools, BASiCS quantifies changes in expression that lie beyond comparisons of means, also allowing the study of changes in cell-to-cell heterogeneity. The latter can be quantified via a biological over-dispersion parameter that measures the excess of variability that is observed with respect to Poisson sampling noise, after normalisation and technical noise removal. Due to the strong mean/over-dispersion confounding that is typically observed for scRNA-seq datasets, BASiCS also tests for changes in residual over-dispersion, defined by residual values with respect to a global mean/over-dispersion trend.

Maintained by Catalina Vallejos. Last updated 5 months ago.

immunooncologynormalizationsequencingrnaseqsoftwaregeneexpressiontranscriptomicssinglecelldifferentialexpressionbayesiancellbiologybioconductor-packagegene-expressionrcpprcpparmadilloscrna-seqsingle-cellopenblascppopenmp

83 stars 10.26 score 368 scripts 1 dependents

jasonjfoster

roll:Rolling and Expanding Statistics

Fast and efficient computation of rolling and expanding statistics for time-series data.

Maintained by Jason Foster. Last updated 2 months ago.

algorithmsrcppstatisticsopenblascppopenmp

116 stars 9.76 score 318 scripts 13 dependents

rblp

Rblpapi:R Interface to 'Bloomberg'

An R Interface to 'Bloomberg' is provided via the 'Blp API'.

Maintained by Dirk Eddelbuettel. Last updated 12 days ago.

bloombergbloomberg-apircppcpp

169 stars 9.41 score 115 scripts

vlarmet

cppRouting:Algorithms for Routing and Solving the Traffic Assignment Problem

Calculation of distances, shortest paths and isochrones on weighted graphs using several variants of Dijkstra algorithm. Proposed algorithms are unidirectional Dijkstra (Dijkstra, E. W. (1959) <doi:10.1007/BF01386390>), bidirectional Dijkstra (Goldberg, Andrew & Fonseca F. Werneck, Renato (2005) <https://archive.siam.org/meetings/alenex05/papers/03agoldberg.pdf>), A* search (P. E. Hart, N. J. Nilsson et B. Raphael (1968) <doi:10.1109/TSSC.1968.300136>), new bidirectional A* (Pijls & Post (2009) <https://repub.eur.nl/pub/16100/ei2009-10.pdf>), Contraction hierarchies (R. Geisberger, P. Sanders, D. Schultes and D. Delling (2008) <doi:10.1007/978-3-540-68552-4_24>), PHAST (D. Delling, A.Goldberg, A. Nowatzyk, R. Werneck (2011) <doi:10.1016/j.jpdc.2012.02.007>). Algorithms for solving the traffic assignment problem are All-or-Nothing assignment, Method of Successive Averages, Frank-Wolfe algorithm (M. Fukushima (1984) <doi:10.1016/0191-2615(84)90029-8>), Conjugate and Bi-Conjugate Frank-Wolfe algorithms (M. Mitradjieva, P. O. Lindberg (2012) <doi:10.1287/trsc.1120.0409>), Algorithm-B (R. B. Dial (2006) <doi:10.1016/j.trb.2006.02.008>).

Maintained by Vincent Larmet. Last updated 11 days ago.

algorithmalgorithm-bbidirectional-a-star-algorithmc-plus-pluscontraction-hierarchiesdijkstra-algorithmdistancefrank-wolfeisochronesparallel-computingrcppshortest-pathstraffic-assignmentcpp

113 stars 7.72 score 39 scripts 4 dependents

janmarvin

readspss:Importing and Exporting SPSS Files

Package to read and write the SPSS file formats.

Maintained by Jan Marvin Garbuszus. Last updated 15 hours ago.

porrcppreadersavspsszsavzlibopensslcpp

12 stars 4.62 score 9 scripts

jasonjfoster

rollshap:Rolling Shapley Values

Analytical computation of rolling Shapley values for time-series data.

Maintained by Jason Foster. Last updated 2 months ago.

algorithmsrcppshapleyopenblascppopenmp

3 stars 2.78 score 1 scripts

janmarvin

readsas:Importing SAS Files

Package to read the SAS file format.

Maintained by Jan Marvin Garbuszus. Last updated 10 months ago.

rcppreadersassas7bdatcpp

3 stars 2.65 score 3 scripts