R-universe search: annotations

bioc

ComplexHeatmap:Make Complex Heatmaps

Complex heatmaps are efficient to visualize associations between different sources of data sets and reveal potential patterns. Here the ComplexHeatmap package provides a highly flexible way to arrange multiple heatmaps and supports various annotation graphics.

Maintained by Zuguang Gu. Last updated 5 months ago.

software visualization sequencing clustering complex-heatmaps heatmap

120.6 match 1.3k stars 16.93 score 16k scripts 151 dependents

bioc

annotate:Annotation for microarrays

Using R enviroments for annotation.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation pathways go

97.4 match 11.41 score 812 scripts 243 dependents

bioc

annotatr:Annotation of Genomic Regions to Genomic Annotations

Given a set of genomic sites/regions (e.g. ChIP-seq peaks, CpGs, differentially methylated CpGs or regions, SNPs, etc.) it is often of interest to investigate the intersecting genomic annotations. Such annotations include those relating to gene models (promoters, 5'UTRs, exons, introns, and 3'UTRs), CpGs (CpG islands, CpG shores, CpG shelves), or regulatory sequences such as enhancers. The annotatr package provides an easy way to summarize and visualize the intersection of genomic sites/regions with genomic annotations.

Maintained by Raymond G. Cavalcante. Last updated 5 months ago.

software annotation genomeannotation functionalgenomics visualization genome-annotation

79.3 match 26 stars 9.76 score 246 scripts 5 dependents

bioc

ChIPpeakAnno:Batch annotation of the peaks identified from either ChIP-seq, ChIP-chip experiments, or any experiments that result in large number of genomic interval data

The package encompasses a range of functions for identifying the closest gene, exon, miRNA, or custom features—such as highly conserved elements and user-supplied transcription factor binding sites. Additionally, users can retrieve sequences around the peaks and obtain enriched Gene Ontology (GO) or Pathway terms. In version 2.0.5 and beyond, new functionalities have been introduced. These include features for identifying peaks associated with bi-directional promoters along with summary statistics (peaksNearBDP), summarizing motif occurrences in peaks (summarizePatternInPeaks), and associating additional identifiers with annotated peaks or enrichedGO (addGeneIDs). The package integrates with various other packages such as biomaRt, IRanges, Biostrings, BSgenome, GO.db, multtest, and stat to enhance its analytical capabilities.

Maintained by Jianhong Ou. Last updated 2 months ago.

annotation chipseq chipchip

76.0 match 8.75 score 584 scripts 6 dependents

maialba3

LipidMS:Lipid Annotation for LC-MS/MS DDA or DIA Data

Lipid annotation in untargeted LC-MS lipidomics based on fragmentation rules. Alcoriza-Balaguer MI, Garcia-Canaveras JC, Lopez A, Conde I, Juan O, Carretero J, Lahoz A (2019) <doi:10.1021/acs.analchem.8b03409>.

Maintained by M Isabel Alcoriza-Balaguer. Last updated 7 months ago.

cpp

112.4 match 2 stars 5.33 score 12 scripts 1 dependents

bioc

ensembldb:Utilities to create and use Ensembl-based annotation databases

The package provides functions to create and use transcript centric annotation databases/packages. The annotation for the databases are directly fetched from Ensembl using their Perl API. The functionality and data is similar to that of the TxDb packages from the GenomicFeatures package, but, in addition to retrieve all gene/transcript models and annotations from the database, ensembldb provides a filter framework allowing to retrieve annotations for specific entries like genes encoded on a chromosome region or transcript models of lincRNA genes. EnsDb databases built with ensembldb contain also protein annotations and mappings between proteins and their encoding transcripts. Finally, ensembldb provides functions to map between genomic, transcript and protein coordinates.

Maintained by Johannes Rainer. Last updated 5 months ago.

genetics annotationdata sequencing coverage annotation bioconductor bioconductor-packages ensembl

32.7 match 35 stars 14.08 score 892 scripts 108 dependents

bioc

ggtree:an R package for visualization of tree and annotation data

'ggtree' extends the 'ggplot2' plotting system which implemented the grammar of graphics. 'ggtree' is designed for visualization and annotation of phylogenetic trees and other tree-like structures with their annotation data.

Maintained by Guangchuang Yu. Last updated 5 months ago.

alignment annotation clustering dataimport multiplesequencealignment phylogenetics reproducibleresearch software visualization annotations ggplot2 phylogenetic-trees

26.9 match 864 stars 16.86 score 5.1k scripts 109 dependents

bioc

RnBeads:RnBeads

RnBeads facilitates comprehensive analysis of various types of DNA methylation data at the genome scale.

Maintained by Fabian Mueller. Last updated 1 months ago.

dnamethylation methylationarray methylseq epigenetics qualitycontrol preprocessing batcheffect differentialmethylation sequencing cpgisland immunooncology twochannel dataimport

58.1 match 6.85 score 169 scripts 1 dependents

bioc

genomation:Summary, annotation and visualization of genomic data

A package for summary and annotation of genomic intervals. Users can visualize and quantify genomic intervals over pre-defined functional regions, such as promoters, exons, introns, etc. The genomic intervals represent regions with a defined chromosome position, which may be associated with a score, such as aligned reads from HT-seq experiments, TF binding sites, methylation scores, etc. The package can use any tabular genomic feature data as long as it has minimal information on the locations of genomic intervals. In addition, It can use BAM or BigWig files as input.

Maintained by Altuna Akalin. Last updated 5 months ago.

annotation sequencing visualization cpgisland cpp

35.7 match 75 stars 11.09 score 738 scripts 5 dependents

ropensci

biomartr:Genomic Data Retrieval

Perform large scale genomic data retrieval and functional annotation retrieval. This package aims to provide users with a standardized way to automate genome, proteome, 'RNA', coding sequence ('CDS'), 'GFF', and metagenome retrieval from 'NCBI RefSeq', 'NCBI Genbank', 'ENSEMBL', and 'UniProt' databases. Furthermore, an interface to the 'BioMart' database (Smedley et al. (2009) <doi:10.1186/1471-2164-10-22>) allows users to retrieve functional annotation for genomic loci. In addition, users can download entire databases such as 'NCBI RefSeq' (Pruitt et al. (2007) <doi:10.1093/nar/gkl842>), 'NCBI nr', 'NCBI nt', 'NCBI Genbank' (Benson et al. (2013) <doi:10.1093/nar/gks1195>), etc. with only one command.

Maintained by Hajk-Georg Drost. Last updated 1 months ago.

biomart genomic-data-retrieval annotation-retrieval database-retrieval ncbi ensembl biological-data-retrieval ensembl-servers genome genome-annotation genome-retrieval genomics meta-analysis metagenomics ncbi-genbank peer-reviewed proteome sequenced-genomes

34.1 match 218 stars 11.35 score 129 scripts 3 dependents

dfsp-spirit

fsbrain:Managing and Visualizing Brain Surface Data

Provides high-level access to neuroimaging data from standard software packages like 'FreeSurfer' <http://freesurfer.net/> on the level of subjects and groups. Load morphometry data, surfaces and brain parcellations based on atlases. Mask data using labels, load data for specific atlas regions only, and visualize data and statistical results directly in 'R'.

Maintained by Tim Schäfer. Last updated 4 months ago.

3d brain dti freesurfer mesh mri neuroimaging research surface visualization voxel

58.3 match 66 stars 6.47 score 15 scripts

bioc

AnnotationDbi:Manipulation of SQLite-based annotations in Bioconductor

Implements a user-friendly interface for querying SQLite-based annotation data packages.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation microarray sequencing genomeannotation bioconductor-package core-package

24.8 match 9 stars 15.05 score 3.6k scripts 769 dependents

bioc

OmnipathR:OmniPath web service client and more

A client for the OmniPath web service (https://www.omnipathdb.org) and many other resources. It also includes functions to transform and pretty print some of the downloaded data, functions to access a number of other resources such as BioPlex, ConsensusPathDB, EVEX, Gene Ontology, Guide to Pharmacology (IUPHAR/BPS), Harmonizome, HTRIdb, Human Phenotype Ontology, InWeb InBioMap, KEGG Pathway, Pathway Commons, Ramilowski et al. 2015, RegNetwork, ReMap, TF census, TRRUST and Vinayagam et al. 2011. Furthermore, OmnipathR features a close integration with the NicheNet method for ligand activity prediction from transcriptomics data, and its R implementation `nichenetr` (available only on github).

Maintained by Denes Turei. Last updated 19 days ago.

graphandnetwork network pathways software thirdpartyclient dataimport datarepresentation genesignaling generegulation systemsbiology transcriptomics singlecell annotation kegg complexes enzyme-ptm networks networks-biology omnipath proteins quarto

35.6 match 126 stars 9.90 score 226 scripts 2 dependents

bioc

RCy3:Functions to Access and Control Cytoscape

Vizualize, analyze and explore networks using Cytoscape via R. Anything you can do using the graphical user interface of Cytoscape, you can now do with a single RCy3 function.

Maintained by Alex Pico. Last updated 5 months ago.

visualization graphandnetwork thirdpartyclient network

26.3 match 52 stars 13.39 score 628 scripts 15 dependents

tidyverse

ggplot2:Create Elegant Data Visualisations Using the Grammar of Graphics

A system for 'declaratively' creating graphics, based on "The Grammar of Graphics". You provide the data, tell 'ggplot2' how to map variables to aesthetics, what graphical primitives to use, and it takes care of the details.

Maintained by Thomas Lin Pedersen. Last updated 9 days ago.

data-visualisation visualisation

12.9 match 6.6k stars 25.10 score 645k scripts 7.5k dependents

kurthornik

NLP:Natural Language Processing Infrastructure

Basic classes and methods for Natural Language Processing.

Maintained by Kurt Hornik. Last updated 4 months ago.

34.3 match 6 stars 9.37 score 1.0k scripts 127 dependents

bioc

biomaRt:Interface to BioMart databases (i.e. Ensembl)

In recent years a wealth of biological data has become available in public data repositories. Easy access to these valuable data resources and firm integration with data analysis is needed for comprehensive bioinformatics data analysis. biomaRt provides an interface to a growing collection of databases implementing the BioMart software suite (<http://www.biomart.org>). The package enables retrieval of large amounts of data in a uniform way without the need to know the underlying database schemas or write complex SQL queries. The most prominent examples of BioMart databases are maintain by Ensembl, which provides biomaRt users direct access to a diverse set of data and enables a wide range of powerful online queries from gene annotation to database mining.

Maintained by Mike Smith. Last updated 2 days ago.

annotation bioconductor biomart ensembl

19.6 match 38 stars 15.99 score 13k scripts 230 dependents

bioc

ChIPseeker:ChIPseeker for ChIP peak Annotation, Comparison, and Visualization

This package implements functions to retrieve the nearest genes around the peak, annotate genomic region of the peak, statstical methods for estimate the significance of overlap among ChIP peak data sets, and incorporate GEO database for user to compare the own dataset with those deposited in database. The comparison can be used to infer cooperative regulation and thus can be used to generate hypotheses. Several visualization functions are implemented to summarize the coverage of the peak experiment, average profile and heatmap of peaks binding to TSS regions, genomic annotation, distance to TSS, and overlap of peaks or genes.

Maintained by Guangchuang Yu. Last updated 5 months ago.

annotation chipseq software visualization multiplecomparison atac-seq chip-seq comparison epigenetics epigenomics

23.6 match 234 stars 13.02 score 1.6k scripts 5 dependents

bioc

GenomicFeatures:Query the gene models of a given organism/assembly

Extract the genomic locations of genes, transcripts, exons, introns, and CDS, for the gene models stored in a TxDb object. A TxDb object is a small database that contains the gene models of a given organism/assembly. Bioconductor provides a small collection of TxDb objects in the form of ready-to-install TxDb packages for the most commonly studied organisms. Additionally, the user can easily make a TxDb object (or package) for the organism/assembly of their choice by using the tools from the txdbmaker package.

Maintained by H. Pagès. Last updated 4 months ago.

genetics infrastructure annotation sequencing genomeannotation bioconductor-package core-package

19.9 match 26 stars 15.34 score 5.3k scripts 339 dependents

bioc

BioNAR:Biological Network Analysis in R

the R package BioNAR, developed to step by step analysis of PPI network. The aim is to quantify and rank each protein’s simultaneous impact into multiple complexes based on network topology and clustering. Package also enables estimating of co-occurrence of diseases across the network and specific clusters pointing towards shared/common mechanisms.

Maintained by Anatoly Sorokin. Last updated 19 days ago.

software graphandnetwork network

49.7 match 3 stars 5.90 score 35 scripts

dfsp-spirit

freesurferformats:Read and Write 'FreeSurfer' Neuroimaging File Formats

Provides functions to read and write neuroimaging data in various file formats, with a focus on 'FreeSurfer' <http://freesurfer.net/> formats. This includes, but is not limited to, the following file formats: 1) MGH/MGZ format files, which can contain multi-dimensional images or other data. Typically they contain time-series of three-dimensional brain scans acquired by magnetic resonance imaging (MRI). They can also contain vertex-wise measures of surface morphometry data. The MGH format is named after the Massachusetts General Hospital, and the MGZ format is a compressed version of the same format. 2) 'FreeSurfer' morphometry data files in binary 'curv' format. These contain vertex-wise surface measures, i.e., one scalar value for each vertex of a brain surface mesh. These are typically values like the cortical thickness or brain surface area at each vertex. 3) Annotation file format. This contains a brain surface parcellation derived from a cortical atlas. 4) Surface file format. Contains a brain surface mesh, given by a list of vertices and a list of faces.

Maintained by Tim Schäfer. Last updated 6 months ago.

brain brain-atlas brain-surfaces curv dti fileformats freesurfer label mesh mgh mri neuroimaging parcellation research surface voxel

35.2 match 23 stars 8.07 score 25 scripts 8 dependents

bioc

MetMashR:Metabolite Mashing with R

A package to merge, filter sort, organise and otherwise mash together metabolite annotation tables. Metabolite annotations can be imported from multiple sources (software) and combined using workflow steps based on S4 class templates derived from the `struct` package. Other modular workflow steps such as filtering, merging, splitting, normalisation and rest-api queries are included.

Maintained by Gavin Rhys Lloyd. Last updated 5 months ago.

workflowstep metabolomics kegg

48.7 match 2 stars 5.81 score 5 scripts

bioc

peakPantheR:Peak Picking and Annotation of High Resolution Experiments

An automated pipeline for the detection, integration and reporting of predefined features across a large number of mass spectrometry data files. It enables the real time annotation of multiple compounds in a single file, or the parallel annotation of multiple compounds in multiple files. A graphical user interface as well as command line functions will assist in assessing the quality of annotation and update fitting parameters until a satisfactory result is obtained.

Maintained by Arnaud Wolfer. Last updated 5 months ago.

massspectrometry metabolomics peakdetection feature-detection mass-spectrometry

39.9 match 12 stars 6.82 score 23 scripts

bioc

scDiagnostics:Cell type annotation diagnostics

The scDiagnostics package provides diagnostic plots to assess the quality of cell type assignments from single cell gene expression profiles. The implemented functionality allows to assess the reliability of cell type annotations, investigate gene expression patterns, and explore relationships between different cell types in query and reference datasets allowing users to detect potential misalignments between reference and query datasets. The package also provides visualization capabilities for diagnostics purposes.

Maintained by Anthony Christidis. Last updated 5 months ago.

annotation classification clustering geneexpression rnaseq singlecell software transcriptomics

34.4 match 8 stars 7.77 score 46 scripts

bioc

RcisTarget:RcisTarget Identify transcription factor binding motifs enriched on a list of genes or genomic regions

RcisTarget identifies transcription factor binding motifs (TFBS) over-represented on a gene list. In a first step, RcisTarget selects DNA motifs that are significantly over-represented in the surroundings of the transcription start site (TSS) of the genes in the gene-set. This is achieved by using a database that contains genome-wide cross-species rankings for each motif. The motifs that are then annotated to TFs and those that have a high Normalized Enrichment Score (NES) are retained. Finally, for each motif and gene-set, RcisTarget predicts the candidate target genes (i.e. genes in the gene-set that are ranked above the leading edge).

Maintained by Gert Hulselmans. Last updated 5 months ago.

generegulation motifannotation transcriptomics transcription genesetenrichment genetarget

26.2 match 37 stars 9.47 score 191 scripts

bioc

txdbmaker:Tools for making TxDb objects from genomic annotations

A set of tools for making TxDb objects from genomic annotations from various sources (e.g. UCSC, Ensembl, and GFF files). These tools allow the user to download the genomic locations of transcripts, exons, and CDS, for a given assembly, and to import them in a TxDb object. TxDb objects are implemented in the GenomicFeatures package, together with flexible methods for extracting the desired features in convenient formats.

Maintained by H. Pagès. Last updated 4 months ago.

infrastructure dataimport annotation genomeannotation genomeassembly genetics sequencing bioconductor-package core-package

25.3 match 3 stars 9.70 score 92 scripts 86 dependents

bioc

SingleR:Reference-Based Single-Cell RNA-Seq Annotation

Performs unbiased cell type recognition from single-cell RNA sequencing data, by leveraging reference transcriptomic datasets of pure cell types to infer the cell of origin of each single cell independently.

Maintained by Aaron Lun. Last updated 28 days ago.

software singlecell geneexpression transcriptomics classification clustering annotation bioconductor singler cpp

19.0 match 182 stars 12.60 score 2.1k scripts 1 dependents

bnosac

udpipe:Tokenization, Parts of Speech Tagging, Lemmatization and Dependency Parsing with the 'UDPipe' 'NLP' Toolkit

This natural language processing toolkit provides language-agnostic 'tokenization', 'parts of speech tagging', 'lemmatization' and 'dependency parsing' of raw text. Next to text parsing, the package also allows you to train annotation models based on data of 'treebanks' in 'CoNLL-U' format as provided at <https://universaldependencies.org/format.html>. The techniques are explained in detail in the paper: 'Tokenizing, POS Tagging, Lemmatizing and Parsing UD 2.0 with UDPipe', available at <doi:10.18653/v1/K17-3009>. The toolkit also contains functionalities for commonly used data manipulations on texts which are enriched with the output of the parser. Namely functionalities and algorithms for collocations, token co-occurrence, document term matrix handling, term frequency inverse document frequency calculations, information retrieval metrics (Okapi BM25), handling of multi-word expressions, keyword detection (Rapid Automatic Keyword Extraction, noun phrase extraction, syntactical patterns) sentiment scoring and semantic similarity analysis.

Maintained by Jan Wijffels. Last updated 2 years ago.

conll dependency-parser lemmatization natural-language-processing nlp pos-tagging r-pkg rcpp text-mining tokenizer udpipe cpp

20.2 match 215 stars 11.83 score 1.2k scripts 9 dependents

luisdva

annotater:Annotate Package Load Calls

Provides non-invasive annotation of package load calls such as \code{library()}, \code{p_load()}, and \code{require()} so that we can have an idea of what the packages we are loading are meant for.

Maintained by Luis D. Verde Arregoitia. Last updated 5 months ago.

35.0 match 102 stars 6.81 score 21 scripts

bioc

ORFik:Open Reading Frames in Genomics

R package for analysis of transcript and translation features through manipulation of sequence data and NGS data like Ribo-Seq, RNA-Seq, TCP-Seq and CAGE. It is generalized in the sense that any transcript region can be analysed, as the name hints to it was made with investigation of ribosomal patterns over Open Reading Frames (ORFs) as it's primary use case. ORFik is extremely fast through use of C++, data.table and GenomicRanges. Package allows to reassign starts of the transcripts with the use of CAGE-Seq data, automatic shifting of RiboSeq reads, finding of Open Reading Frames for whole genomes and much more.

Maintained by Haakon Tjeldnes. Last updated 27 days ago.

immunooncology software sequencing riboseq rnaseq functionalgenomics coverage alignment dataimport cpp

21.9 match 33 stars 10.63 score 115 scripts 2 dependents

bioc

IsoformSwitchAnalyzeR:Identify, Annotate and Visualize Isoform Switches with Functional Consequences from both short- and long-read RNA-seq data

Analysis of alternative splicing and isoform switches with predicted functional consequences (e.g. gain/loss of protein domains etc.) from quantification of all types of RNASeq by tools such as Kallisto, Salmon, StringTie, Cufflinks/Cuffdiff etc.

Maintained by Kristoffer Vitting-Seerup. Last updated 5 months ago.

geneexpression transcription alternativesplicing differentialexpression differentialsplicing visualization statisticalmethod transcriptomevariant biomedicalinformatics functionalgenomics systemsbiology transcriptomics rnaseq annotation functionalprediction geneprediction dataimport multiplecomparison batcheffect immunooncology

23.8 match 108 stars 9.26 score 125 scripts

aphalo

ggpmisc:Miscellaneous Extensions to 'ggplot2'

Extensions to 'ggplot2' respecting the grammar of graphics paradigm. Statistics: locate and tag peaks and valleys; label plot with the equation of a fitted polynomial or other types of models; labels with P-value, R^2 or adjusted R^2 or information criteria for fitted models; label with ANOVA table for fitted models; label with summary for fitted models. Model fit classes for which suitable methods are provided by package 'broom' and 'broom.mixed' are supported. Scales and stats to build volcano and quadrant plots based on outcomes, fold changes, p-values and false discovery rates.

Maintained by Pedro J. Aphalo. Last updated 4 months ago.

data-analysis dataviz ggplot2-annotations ggplot2-stats statistics

16.4 match 105 stars 13.32 score 4.4k scripts 14 dependents

bioc

crisprDesign:Comprehensive design of CRISPR gRNAs for nucleases and base editors

Provides a comprehensive suite of functions to design and annotate CRISPR guide RNA (gRNAs) sequences. This includes on- and off-target search, on-target efficiency scoring, off-target scoring, full gene and TSS contextual annotations, and SNP annotation (human only). It currently support five types of CRISPR modalities (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition, CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported, including DNA- and RNA-target nucleases such as Cas9, Cas12a, and Cas13d. All types of base editors are also supported. gRNA design can be performed on reference genomes, transcriptomes, and custom DNA and RNA sequences. Both unpaired and paired gRNA designs are enabled.

Maintained by Jean-Philippe Fortin. Last updated 11 days ago.

crispr functionalgenomics genetarget bioconductor bioconductor-package crispr-cas9 crispr-design crispr-target genomics-analysis grna grna-sequence grna-sequences sgrna sgrna-design

26.4 match 22 stars 8.28 score 80 scripts 3 dependents

stemangiola

tidyHeatmap:A Tidy Implementation of Heatmap

This is a tidy implementation for heatmap. At the moment it is based on the (great) package 'ComplexHeatmap'. The goal of this package is to interface a tidy data frame with this powerful tool. Some of the advantages are: Row and/or columns colour annotations are easy to integrate just specifying one parameter (column names). Custom grouping of rows is easy to specify providing a grouped tbl. For example: df %>% group_by(...). Labels size adjusted by row and column total number. Default use of Brewer and Viridis palettes.

Maintained by Stefano Mangiola. Last updated 1 months ago.

assaydomain infrastructure brewer complexheatmap custom-palette dplyr graphviz heatmap mtcars plotting rstudio scale tibble tidy tidy-data-frame tidybulk tidyverse viridis

21.3 match 335 stars 10.23 score 197 scripts 1 dependents

zhanxw

seqminer:Efficiently Read Sequence Data (VCF Format, BCF Format, METAL Format and BGEN Format) into R

Integrate sequencing data (Variant call format, e.g. VCF or BCF) or meta-analysis results in R. This package can help you (1) read VCF/BCF/BGEN files by chromosomal ranges (e.g. 1:100-200); (2) read RareMETAL summary statistics files; (3) read tables from a tabix-indexed files; (4) annotate VCF/BCF files; (5) create customized workflow based on Makefile.

Maintained by Xiaowei Zhan. Last updated 6 months ago.

annotation bcf bgen meta-analysis next-generation-sequencing plink sequencing tabix vcf workflow zlib bzip2 libzstd sqlite3 cpp

25.9 match 30 stars 8.29 score 111 scripts 6 dependents

bioc

clusterProfiler:A universal enrichment tool for interpreting omics data

This package supports functional characteristics of both coding and non-coding genomics data for thousands of species with up-to-date gene annotation. It provides a univeral interface for gene functional annotation from a variety of sources and thus can be applied in diverse scenarios. It provides a tidy interface to access, manipulate, and visualize enrichment results to help users achieve efficient data interpretation. Datasets obtained from multiple treatments and time points can be analyzed and compared in a single run, easily revealing functional consensus and differences among distinct conditions.

Maintained by Guangchuang Yu. Last updated 4 months ago.

annotation clustering genesetenrichment go kegg multiplecomparison pathways reactome visualization enrichment-analysis gsea

12.5 match 1.1k stars 17.03 score 11k scripts 48 dependents

bioc

AnnotationForge:Tools for building SQLite-based annotation data packages

Provides code for generating Annotation packages and their databases. Packages produced are intended to be used with AnnotationDbi.

Maintained by Bioconductor Package Maintainer. Last updated 3 days ago.

annotation infrastructure bioconductor-package core-package

22.0 match 5 stars 9.62 score 143 scripts 19 dependents

bioc

AnnotationFilter:Facilities for Filtering Bioconductor Annotation Resources

This package provides class and other infrastructure to implement filters for manipulating Bioconductor annotation resources. The filters will be used by ensembldb, Organism.dplyr, and other packages.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation infrastructure software bioconductor-package core-package

20.5 match 5 stars 10.20 score 45 scripts 162 dependents

bioc

Category:Category Analysis

A collection of tools for performing category (gene set enrichment) analysis.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation go pathways genesetenrichment

26.3 match 7.93 score 183 scripts 16 dependents

edwbaker

sonicscrewdriver:Bioacoustic Analysis and Publication Tools

Provides tools for manipulating sound files for bioacoustic analysis, and preparing analyses these for publication. The package validates that values are physically possible wherever feasible.

Maintained by Ed Baker. Last updated 1 months ago.

bioacoustics ecoacoustics

28.8 match 6 stars 7.12 score 26 scripts

taxonomicallyinformedannotation

tima:Taxonomically Informed Metabolite Annotation

This package provides the infrastructure to perform Taxonomically Informed Metabolite Annotation.

Maintained by Adriano Rutz. Last updated 6 days ago.

metabolite annotation chemotaxonomy scoring system natural products computational metabolomics taxonomic distance specialized metabolome

30.2 match 9 stars 6.55 score 32 scripts 2 dependents

bioc

categoryCompare:Meta-analysis of high-throughput experiments using feature annotations

Calculates significant annotations (categories) in each of two (or more) feature (i.e. gene) lists, determines the overlap between the annotations, and returns graphical and tabular data about the significant annotations and which combinations of feature lists the annotations were found to be significant. Interactive exploration is facilitated through the use of RCytoscape (heavily suggested).

Maintained by Robert M. Flight. Last updated 5 months ago.

annotation go multiplecomparison pathways geneexpression bioconductor

29.4 match 6 stars 6.68 score

bioc

MSstatsPTM:Statistical Characterization of Post-translational Modifications

MSstatsPTM provides general statistical methods for quantitative characterization of post-translational modifications (PTMs). Supports DDA, DIA, SRM, and tandem mass tag (TMT) labeling. Typically, the analysis involves the quantification of PTM sites (i.e., modified residues) and their corresponding proteins, as well as the integration of the quantification results. MSstatsPTM provides functions for summarization, estimation of PTM site abundance, and detection of changes in PTMs across experimental conditions.

Maintained by Devon Kohler. Last updated 4 months ago.

immunooncology massspectrometry proteomics software differentialexpression onechannel twochannel normalization qualitycontrol post-translational-modification cpp

24.4 match 10 stars 7.98 score 36 scripts 2 dependents

valcu

annotator:Image Annotation and Polygon Outlining using Free Drawing

Provides functions to create image annotations through polygon outlining. Annotator has the same function as 'graphics::locator()' but achieves its purpose through drawing, rather than multiple mouse clicks. It is based on the 'htmlwidgets' package and 'fabric.js' JavaScript library <http://fabricjs.com/>.

Maintained by Mihai Valcu. Last updated 1 years ago.

60.9 match 3 stars 3.18 score 4 scripts

bioc

CAMERA:Collection of annotation related methods for mass spectrometry data

Annotation of peaklists generated by xcms, rule based annotation of isotopes and adducts, isotope validation, EIC correlation based tagging of unknown adducts and fragments

Maintained by Steffen Neumann. Last updated 5 months ago.

immunooncology massspectrometry metabolomics

18.7 match 11 stars 10.27 score 175 scripts 6 dependents

bioc

plotgardener:Coordinate-Based Genomic Visualization Package for R

Coordinate-based genomic visualization package for R. It grants users the ability to programmatically produce complex, multi-paneled figures. Tailored for genomics, plotgardener allows users to visualize large complex genomic datasets and provides exquisite control over how plots are placed and arranged on a page.

Maintained by Nicole Kramer. Last updated 5 months ago.

visualization genomeannotation functionalgenomics genomeassembly hic cpp

18.8 match 308 stars 10.16 score 167 scripts 3 dependents

bioc

recount:Explore and download data from the recount project

Explore and download data from the recount project available at https://jhubiostatistics.shinyapps.io/recount/. Using the recount package you can download RangedSummarizedExperiment objects at the gene, exon or exon-exon junctions level, the raw counts, the phenotype metadata used, the urls to the sample coverage bigWig files or the mean coverage bigWig file for a particular study. The RangedSummarizedExperiment objects can be used by different packages for performing differential expression analysis. Using http://bioconductor.org/packages/derfinder you can perform annotation-agnostic differential expression analyses with the data from the recount project as described at http://www.nature.com/nbt/journal/v35/n4/full/nbt.3838.html.

Maintained by Leonardo Collado-Torres. Last updated 3 months ago.

coverage differentialexpression geneexpression rnaseq sequencing software dataimport immunooncology annotation-agnostic bioconductor count derfinder deseq2 exon gene human illumina junction recount

19.6 match 41 stars 9.57 score 498 scripts 3 dependents

bioc

GenomicRanges:Representation and manipulation of genomic intervals

The ability to efficiently represent and manipulate genomic annotations and alignments is playing a central role when it comes to analyzing high-throughput sequencing data (a.k.a. NGS data). The GenomicRanges package defines general purpose containers for storing and manipulating genomic intervals and variables defined along a genome. More specialized containers for representing and manipulating short alignments against a reference genome, or a matrix-like summarization of an experiment, are defined in the GenomicAlignments and SummarizedExperiment packages, respectively. Both packages build on top of the GenomicRanges infrastructure.

Maintained by Hervé Pagès. Last updated 4 months ago.

genetics infrastructure datarepresentation sequencing annotation genomeannotation coverage bioconductor-package core-package

10.5 match 44 stars 17.75 score 13k scripts 1.3k dependents

bioc

survcomp:Performance Assessment and Comparison for Survival Analysis

Assessment and Comparison for Performance of Risk Prediction (Survival) Models.

Maintained by Benjamin Haibe-Kains. Last updated 5 months ago.

geneexpression differentialexpression visualization cpp

21.7 match 8.46 score 448 scripts 12 dependents

bioc

CompoundDb:Creating and Using (Chemical) Compound Annotation Databases

CompoundDb provides functionality to create and use (chemical) compound annotation databases from a variety of different sources such as LipidMaps, HMDB, ChEBI or MassBank. The database format allows to store in addition MS/MS spectra along with compound information. The package provides also a backend for Bioconductor's Spectra package and allows thus to match experimetal MS/MS spectra against MS/MS spectra in the database. Databases can be stored in SQLite format and are thus portable.

Maintained by Johannes Rainer. Last updated 2 months ago.

massspectrometry metabolomics annotation databases mass-spectrometry

20.9 match 17 stars 8.40 score 69 scripts 1 dependents

obiba

opalr:'Opal' Data Repository Client and 'DataSHIELD' Utils

Data integration Web application for biobanks by 'OBiBa'. 'Opal' is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. 'Opal' is such a central repository. It can import, process, validate, query, analyze, report, and export data. 'Opal' is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This 'Opal' client allows to interact with 'Opal' web services and to perform operations on the R server side. 'DataSHIELD' administration tools are also provided.

Maintained by Yannick Marcon. Last updated 2 months ago.

22.6 match 3 stars 7.76 score 179 scripts 2 dependents

bioc

VariantAnnotation:Annotation of Genetic Variants

Annotate variants, compute amino acid coding changes, predict coding outcomes.

Maintained by Bioconductor Package Maintainer. Last updated 2 months ago.

dataimport sequencing snp annotation genetics variantannotation curl bzip2 xz-utils zlib

15.1 match 11.39 score 1.9k scripts 152 dependents

bioc

musicatk:Mutational Signature Comprehensive Analysis Toolkit

Mutational signatures are carcinogenic exposures or aberrant cellular processes that can cause alterations to the genome. We created musicatk (MUtational SIgnature Comprehensive Analysis ToolKit) to address shortcomings in versatility and ease of use in other pre-existing computational tools. Although many different types of mutational data have been generated, current software packages do not have a flexible framework to allow users to mix and match different types of mutations in the mutational signature inference process. Musicatk enables users to count and combine multiple mutation types, including SBS, DBS, and indels. Musicatk calculates replication strand, transcription strand and combinations of these features along with discovery from unique and proprietary genomic feature associated with any mutation type. Musicatk also implements several methods for discovery of new signatures as well as methods to infer exposure given an existing set of signatures. Musicatk provides functions for visualization and downstream exploratory analysis including the ability to compare signatures between cohorts and find matching signatures in COSMIC V2 or COSMIC V3.

Maintained by Joshua D. Campbell. Last updated 5 months ago.

software biologicalquestion somaticmutation variantannotation

24.4 match 13 stars 7.02 score 20 scripts

bioc

rtracklayer:R interface to genome annotation files and the UCSC genome browser

Extensible framework for interacting with multiple genome browsers (currently UCSC built-in) and manipulating annotation tracks in various formats (currently GFF, BED, bedGraph, BED15, WIG, BigWig and 2bit built-in). The user may export/import tracks to/from the supported browsers, as well as query and modify the browser state, such as the current viewport.

Maintained by Michael Lawrence. Last updated 8 days ago.

annotation visualization dataimport zlib openssl curl

13.3 match 12.66 score 6.7k scripts 481 dependents

bioc

SummarizedExperiment:A container (S4 class) for matrix-like assays

The SummarizedExperiment container contains one or more assays, each represented by a matrix-like object of numeric or other mode. The rows typically represent genomic ranges of interest and the columns represent samples.

Maintained by Hervé Pagès. Last updated 5 months ago.

genetics infrastructure sequencing annotation coverage genomeannotation bioconductor-package core-package

10.0 match 34 stars 16.85 score 8.6k scripts 1.2k dependents

bioc

CAGEfightR:Analysis of Cap Analysis of Gene Expression (CAGE) data using Bioconductor

CAGE is a widely used high throughput assay for measuring transcription start site (TSS) activity. CAGEfightR is an R/Bioconductor package for performing a wide range of common data analysis tasks for CAGE and 5'-end data in general. Core functionality includes: import of CAGE TSSs (CTSSs), tag (or unidirectional) clustering for TSS identification, bidirectional clustering for enhancer identification, annotation with transcript and gene models, correlation of TSS and enhancer expression, calculation of TSS shapes, quantification of CAGE expression as expression matrices and genome brower visualization.

Maintained by Malte Thodberg. Last updated 5 months ago.

software transcription coverage geneexpression generegulation peakdetection dataimport datarepresentation transcriptomics sequencing annotation genomebrowsers normalization preprocessing visualization

22.5 match 8 stars 7.46 score 67 scripts 1 dependents

bioc

GenomeInfoDb:Utilities for manipulating chromosome names, including modifying them to follow a particular naming style

Contains data and functions that define and allow translation between different chromosome sequence naming conventions (e.g., "chr1" versus "1"), including a function that attempts to place sequence names in their natural, rather than lexicographic, order.

Maintained by Hervé Pagès. Last updated 2 months ago.

genetics datarepresentation annotation genomeannotation bioconductor-package core-package

10.0 match 32 stars 16.46 score 1.3k scripts 1.7k dependents

bioc

enrichplot:Visualization of Functional Enrichment Result

The 'enrichplot' package implements several visualization methods for interpreting functional enrichment results obtained from ORA or GSEA analysis. It is mainly designed to work with the 'clusterProfiler' package suite. All the visualization methods are developed based on 'ggplot2' graphics.

Maintained by Guangchuang Yu. Last updated 2 months ago.

annotation genesetenrichment go kegg pathways software visualization enrichment-analysis pathway-analysis

10.0 match 239 stars 15.71 score 3.1k scripts 58 dependents

bioc

DelayedArray:A unified framework for working transparently with on-disk and in-memory array-like datasets

Wrapping an array-like object (typically an on-disk object) in a DelayedArray object allows one to perform common array operations on it without loading the object in memory. In order to reduce memory usage and optimize performance, operations on the object are either delayed or executed using a block processing mechanism. Note that this also works on in-memory array-like objects like DataFrame objects (typically with Rle columns), Matrix objects, ordinary arrays and, data frames.

Maintained by Hervé Pagès. Last updated 1 months ago.

infrastructure datarepresentation annotation genomeannotation bioconductor-package core-package u24ca289073

10.0 match 27 stars 15.59 score 538 scripts 1.2k dependents

bioc

hiAnnotator:Functions for annotating GRanges objects

hiAnnotator contains set of functions which allow users to annotate a GRanges object with custom set of annotations. The basic philosophy of this package is to take two GRanges objects (query & subject) with common set of seqnames (i.e. chromosomes) and return associated annotation per seqnames and rows from the query matching seqnames and rows from the subject (i.e. genes or cpg islands). The package comes with three types of annotation functions which calculates if a position from query is: within a feature, near a feature, or count features in defined window sizes. Moreover, each function is equipped with parallel backend to utilize the foreach package. In addition, the package is equipped with wrapper functions, which finds appropriate columns needed to make a GRanges object from a common data frame.

Maintained by Nirav V Malani. Last updated 5 months ago.

software annotation

33.1 match 4.65 score 15 scripts 1 dependents

marce10

warbleR:Streamline Bioacoustic Analysis

Functions aiming to facilitate the analysis of the structure of animal acoustic signals in 'R'. 'warbleR' makes use of the basic sound analysis tools from the packages 'tuneR' and 'seewave', and offers new tools for explore and quantify acoustic signal structure. The package allows to organize and manipulate multiple sound files, create spectrograms of complete recordings or individual signals in different formats, run several measures of acoustic structure, and characterize different structural levels in acoustic signals.

Maintained by Marcelo Araya-Salas. Last updated 2 months ago.

animal-acoustic-signals audio-processing bioacoustics spectrogram streamline-analysis cpp

13.7 match 54 stars 11.01 score 270 scripts 4 dependents

bioc

ViSEAGO:ViSEAGO: a Bioconductor package for clustering biological functions using Gene Ontology and semantic similarity

The main objective of ViSEAGO package is to carry out a data mining of biological functions and establish links between genes involved in the study. We developed ViSEAGO in R to facilitate functional Gene Ontology (GO) analysis of complex experimental design with multiple comparisons of interest. It allows to study large-scale datasets together and visualize GO profiles to capture biological knowledge. The acronym stands for three major concepts of the analysis: Visualization, Semantic similarity and Enrichment Analysis of Gene Ontology. It provides access to the last current GO annotations, which are retrieved from one of NCBI EntrezGene, Ensembl or Uniprot databases for several species. Using available R packages and novel developments, ViSEAGO extends classical functional GO analysis to focus on functional coherence by aggregating closely related biological themes while studying multiple datasets at once. It provides both a synthetic and detailed view using interactive functionalities respecting the GO graph structure and ensuring functional coherence supplied by semantic similarity. ViSEAGO has been successfully applied on several datasets from different species with a variety of biological questions. Results can be easily shared between bioinformaticians and biologists, enhancing reporting capabilities while maintaining reproducibility.

Maintained by Aurelien Brionne. Last updated 2 months ago.

software annotation go genesetenrichment multiplecomparison clustering visualization

22.7 match 6.64 score 22 scripts

bioc

metaMS:MS-based metabolomics annotation pipeline

MS-based metabolomics data processing and compound annotation pipeline.

Maintained by Yann Guitton. Last updated 5 months ago.

immunooncology massspectrometry metabolomics

20.1 match 15 stars 7.50 score 15 scripts

bioc

GOexpress:Visualise microarray and RNAseq data using gene ontology annotations

The package contains methods to visualise the expression profile of genes from a microarray or RNA-seq experiment, and offers a supervised clustering approach to identify GO terms containing genes with expression levels that best classify two or more predefined groups of samples. Annotations for the genes present in the expression dataset may be obtained from Ensembl through the biomaRt package, if not provided by the user. The default random forest framework is used to evaluate the capacity of each gene to cluster samples according to the factor of interest. Finally, GO terms are scored by averaging the rank (alternatively, score) of their respective gene sets to cluster the samples. P-values may be computed to assess the significance of GO term ranking. Visualisation function include gene expression profile, gene ontology-based heatmaps, and hierarchical clustering of experimental samples using gene expression data.

Maintained by Kevin Rue-Albrecht. Last updated 5 months ago.

software geneexpression transcription differentialexpression genesetenrichment datarepresentation clustering timecourse microarray sequencing rnaseq annotation multiplecomparison pathways go visualization immunooncology bioconductor bioconductor-package bioconductor-stats geneontology geneset-enrichment

22.2 match 9 stars 6.75 score 31 scripts

bioc

DOSE:Disease Ontology Semantic and Enrichment analysis

This package implements five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang respectively for measuring semantic similarities among DO terms and gene products. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented for discovering disease associations of high-throughput biological data.

Maintained by Guangchuang Yu. Last updated 5 months ago.

annotation visualization multiplecomparison genesetenrichment pathways software disease-ontology enrichment-analysis semantic-similarity

10.0 match 119 stars 14.97 score 2.0k scripts 61 dependents

bioc

GOSemSim:GO-terms Semantic Similarity Measures

The semantic comparisons of Gene Ontology (GO) annotations provide quantitative ways to compute similarities between genes and gene groups, and have became important basis for many bioinformatics analysis approaches. GOSemSim is an R package for semantic similarity computation among GO terms, sets of GO terms, gene products and gene clusters. GOSemSim implemented five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang respectively.

Maintained by Guangchuang Yu. Last updated 5 months ago.

annotation go clustering pathways network software bioinformatics gene-ontology semantic-similarity cpp

10.5 match 63 stars 14.12 score 708 scripts 68 dependents

uscbiostats

aphylo:Statistical Inference and Prediction of Annotations in Phylogenetic Trees

Implements a parsimonious evolutionary model to analyze and predict gene-functional annotations in phylogenetic trees as described in Vega Yon et al. (2021) <doi:10.1371/journal.pcbi.1007948>. Focusing on computational efficiency, 'aphylo' makes it possible to estimate pooled phylogenetic models, including thousands (hundreds) of annotations (trees) in the same run. The package also provides the tools for visualization of annotated phylogenies, calculation of posterior probabilities (prediction) and goodness-of-fit assessment featured in Vega Yon et al. (2021).

Maintained by George Vega Yon. Last updated 1 years ago.

annotations inference phylogenetics rcpparmadillo cpp

26.9 match 6 stars 5.49 score 104 scripts

bioc

genefu:Computation of Gene Expression-Based Signatures in Breast Cancer

This package contains functions implementing various tasks usually required by gene expression analysis, especially in breast cancer studies: gene mapping between different microarray platforms, identification of molecular subtypes, implementation of published gene signatures, gene selection, and survival analysis.

Maintained by Benjamin Haibe-Kains. Last updated 4 months ago.

differentialexpression geneexpression visualization clustering classification

19.8 match 7.42 score 193 scripts 3 dependents

bioc

MetaboAnnotation:Utilities for Annotation of Metabolomics Data

High level functions to assist in annotation of (metabolomics) data sets. These include functions to perform simple tentative annotations based on mass matching but also functions to consider m/z and retention times for annotation of LC-MS features given that respective reference values are available. In addition, the function provides high-level functions to simplify matching of LC-MS/MS spectra against spectral libraries and objects and functionality to represent and manage such matched data.

Maintained by Johannes Rainer. Last updated 3 months ago.

infrastructure metabolomics massspectrometry annotation mass-spectromtry

20.8 match 15 stars 6.98 score 35 scripts

bioc

Heatplus:Heatmaps with row and/or column covariates and colored clusters

Display a rectangular heatmap (intensity plot) of a data matrix. By default, both samples (columns) and features (row) of the matrix are sorted according to a hierarchical clustering, and the corresponding dendrogram is plotted. Optionally, panels with additional information about samples and features can be added to the plot.

Maintained by Alexander Ploner. Last updated 5 months ago.

microarray visualization

19.1 match 7.63 score 94 scripts 5 dependents

bioc

KEGGREST:Client-side REST access to the Kyoto Encyclopedia of Genes and Genomes (KEGG)

A package that provides a client interface to the Kyoto Encyclopedia of Genes and Genomes (KEGG) REST API. Only for academic use by academic users belonging to academic institutions (see <https://www.kegg.jp/kegg/rest/>). Note that KEGGREST is based on KEGGSOAP by J. Zhang, R. Gentleman, and Marc Carlson, and KEGG (python package) by Aurelien Mazurie.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation pathways thirdpartyclient kegg bioconductor-package core-package

10.0 match 9 stars 14.46 score 688 scripts 775 dependents

bioc

gemma.R:A wrapper for Gemma's Restful API to access curated gene expression data and differential expression analyses

Low- and high-level wrappers for Gemma's RESTful API. They enable access to curated expression and differential expression data from over 10,000 published studies. Gemma is a web site, database and a set of tools for the meta-analysis, re-use and sharing of genomics data, currently primarily targeted at the analysis of gene expression profiles.

Maintained by Ogan Mancarci. Last updated 4 months ago.

software dataimport microarray singlecell thirdpartyclient differentialexpression geneexpression bayesian annotation experimentaldesign normalization batcheffect preprocessing bioinformatics gemma genomics transcriptomics

19.1 match 10 stars 7.57 score 26 scripts

melff

memisc:Management of Survey Data and Presentation of Analysis Results

An infrastructure for the management of survey data including value labels, definable missing values, recoding of variables, production of code books, and import of (subsets of) 'SPSS' and 'Stata' files is provided. Further, the package allows to produce tables and data frames of arbitrary descriptive statistics and (almost) publication-ready tables of regression model estimates, which can be exported to 'LaTeX' and HTML.

Maintained by Martin Elff. Last updated 11 days ago.

survey-data

11.7 match 46 stars 12.34 score 1.2k scripts 13 dependents

bioc

BSgenome:Software infrastructure for efficient representation of full genomes and their SNPs

Infrastructure shared by all the Biostrings-based genome data packages.

Maintained by Hervé Pagès. Last updated 2 months ago.

genetics infrastructure datarepresentation sequencematching annotation snp bioconductor-package core-package

10.0 match 9 stars 14.12 score 1.2k scripts 269 dependents

bioc

psichomics:Graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation

Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

Maintained by Nuno Saraiva-Agostinho. Last updated 5 months ago.

sequencing rnaseq alternativesplicing differentialsplicing transcription gui principalcomponent survival biomedicalinformatics transcriptomics immunooncology visualization multiplecomparison geneexpression differentialexpression alternative-splicing bioconductor data-analyses differential-gene-expression differential-splicing-analysis gene-expression gtex recount2 rna-seq-data splicing-quantification sra tcga vast-tools cpp

20.2 match 36 stars 6.95 score 31 scripts

bioc

hermes:Preprocessing, analyzing, and reporting of RNA-seq data

Provides classes and functions for quality control, filtering, normalization and differential expression analysis of pre-processed `RNA-seq` data. Data can be imported from `SummarizedExperiment` as well as `matrix` objects and can be annotated from `BioMart`. Filtering for genes without too low expression or containing required annotations, as well as filtering for samples with sufficient correlation to other samples or total number of reads is supported. The standard normalization methods including cpm, rpkm and tpm can be used, and 'DESeq2` as well as voom differential expression analyses are available.

Maintained by Daniel Sabanés Bové. Last updated 5 months ago.

rnaseq differentialexpression normalization preprocessing qualitycontrol rna-seq statistical-engineering

18.0 match 11 stars 7.77 score 48 scripts 1 dependents

bioc

derfinder:Annotation-agnostic differential expression analysis of RNA-seq data at base-pair resolution via the DER Finder approach

This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package: (1) single base-level F-statistics and (2) DER identification at the expressed regions-level. The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.

Maintained by Leonardo Collado-Torres. Last updated 3 months ago.

differentialexpression sequencing rnaseq chipseq differentialpeakcalling software immunooncology coverage annotation-agnostic bioconductor derfinder

13.9 match 42 stars 10.03 score 78 scripts 6 dependents

bioc

OrganismDbi:Software to enable the smooth interfacing of different database packages

The package enables a simple unified interface to several annotation packages each of which has its own schema by taking advantage of the fact that each of these packages implements a select methods.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation infrastructure

18.7 match 7.45 score 34 scripts 35 dependents

bioc

gDRcore:Processing functions and interface to process and analyze drug dose-response data

This package contains core functions to process and analyze drug response data. The package provides tools for normalizing, averaging, and calculation of gDR metrics data. All core functions are wrapped into the pipeline function allowing analyzing the data in a straightforward way.

Maintained by Arkadiusz Gladki. Last updated 4 days ago.

software shinyapps cpp

19.0 match 2 stars 7.25 score 4 scripts 1 dependents

moseleybioinformaticslab

categoryCompare2:Meta-Analysis of High-Throughput Experiments Using Feature Annotations

Facilitates comparison of significant annotations (categories) generated on one or more feature lists. Interactive exploration is facilitated through the use of RCytoscape (heavily suggested).

Maintained by Robert M Flight. Last updated 5 months ago.

annotation go multiplecomparison pathways geneexpression bioconductor bioinformatics gene-annotation gene-expression gene-sets

55.6 match 1 stars 2.48 score 9 scripts

emmanuelparadis

ape:Analyses of Phylogenetics and Evolution

Functions for reading, writing, plotting, and manipulating phylogenetic trees, analyses of comparative data in a phylogenetic framework, ancestral character analyses, analyses of diversification and macroevolution, computing distances from DNA sequences, reading and writing nucleotide sequences as well as importing from BioConductor, and several tools such as Mantel's test, generalized skyline plots, graphical exploration of phylogenetic data (alex, trex, kronoviz), estimation of absolute evolutionary rates and clock-like trees using mean path lengths and penalized likelihood, dating trees with non-contemporaneous sequences, translating DNA into AA sequences, and assessing sequence alignments. Phylogeny estimation can be done with the NJ, BIONJ, ME, MVR, SDM, and triangle methods, and several methods handling incomplete distance matrices (NJ*, BIONJ*, MVR*, and the corresponding triangle method). Some functions call external applications (PhyML, Clustal, T-Coffee, Muscle) whose results are returned into R.

Maintained by Emmanuel Paradis. Last updated 10 hours ago.

openblas cpp

7.9 match 64 stars 17.22 score 13k scripts 599 dependents

bioc

circRNAprofiler:circRNAprofiler: An R-Based Computational Framework for the Downstream Analysis of Circular RNAs

R-based computational framework for a comprehensive in silico analysis of circRNAs. This computational framework allows to combine and analyze circRNAs previously detected by multiple publicly available annotation-based circRNA detection tools. It covers different aspects of circRNAs analysis from differential expression analysis, evolutionary conservation, biogenesis to functional analysis.

Maintained by Simona Aufiero. Last updated 5 months ago.

annotation structuralprediction functionalprediction geneprediction genomeassembly differentialexpression

23.4 match 10 stars 5.78 score 5 scripts

animint

animint2:Animated Interactive Grammar of Graphics

Functions are provided for defining animated, interactive data visualizations in R code, and rendering on a web page. The 2018 Journal of Computational and Graphical Statistics paper, <doi:10.1080/10618600.2018.1513367> describes the concepts implemented.

Maintained by Toby Hocking. Last updated 27 days ago.

15.2 match 64 stars 8.87 score 173 scripts

stuart-lab

Signac:Analysis of Single-Cell Chromatin Data

A framework for the analysis and exploration of single-cell chromatin data. The 'Signac' package contains functions for quantifying single-cell chromatin data, computing per-cell quality control metrics, dimension reduction and normalization, visualization, and DNA sequence motif analysis. Reference: Stuart et al. (2021) <doi:10.1038/s41592-021-01282-5>.

Maintained by Tim Stuart. Last updated 7 months ago.

atac bioinformatics single-cell zlib cpp

11.0 match 349 stars 12.19 score 3.7k scripts 1 dependents

bioc

maftools:Summarize, Analyze and Visualize MAF Files

Analyze and visualize Mutation Annotation Format (MAF) files from large scale sequencing studies. This package provides various functions to perform most commonly used analyses in cancer genomics and to create feature rich customizable visualzations with minimal effort.

Maintained by Anand Mayakonda. Last updated 5 months ago.

datarepresentation dnaseq visualization drivermutation variantannotation featureextraction classification somaticmutation sequencing functionalgenomics survival bioinformatics cancer-genome-atlas cancer-genomics genomics maf-files tcga curl bzip2 xz-utils zlib

9.1 match 459 stars 14.63 score 948 scripts 18 dependents

pyanglab

ClueR:Cluster Evaluation

CLUster Evaluation (CLUE) is a computational method for identifying optimal number of clusters in a given time-course dataset clustered by cmeans or kmeans algorithms and subsequently identify key kinases or pathways from each cluster. Its implementation in R is called ClueR. See README on <https://github.com/PYangLab/ClueR> for more details. P Yang et al. (2015) <doi:10.1371/journal.pcbi.1004403>.

Maintained by Pengyi Yang. Last updated 1 years ago.

31.5 match 10 stars 4.23 score 17 scripts

bioc

methylKit:DNA methylation analysis from high-throughput bisulfite sequencing results

methylKit is an R package for DNA methylation analysis and annotation from high-throughput bisulfite sequencing. The package is designed to deal with sequencing data from RRBS and its variants, but also target-capture methods and whole genome bisulfite sequencing. It also has functions to analyze base-pair resolution 5hmC data from experimental protocols such as oxBS-Seq and TAB-Seq. Methylation calling can be performed directly from Bismark aligned BAM files.

Maintained by Altuna Akalin. Last updated 16 days ago.

dnamethylation sequencing methylseq genome-biology methylation statistical-analysis visualization curl bzip2 xz-utils zlib cpp

11.3 match 220 stars 11.80 score 578 scripts 3 dependents

bioc

HDF5Array:HDF5 datasets as array-like objects in R

The HDF5Array package is an HDF5 backend for DelayedArray objects. It implements the HDF5Array, H5SparseMatrix, H5ADMatrix, and TENxMatrix classes, 4 convenient and memory-efficient array-like containers for representing and manipulating either: (1) a conventional (a.k.a. dense) HDF5 dataset, (2) an HDF5 sparse matrix (stored in CSR/CSC/Yale format), (3) the central matrix of an h5ad file (or any matrix in the /layers group), or (4) a 10x Genomics sparse matrix. All these containers are DelayedArray extensions and thus support all operations (delayed or block-processed) supported by DelayedArray objects.

Maintained by Hervé Pagès. Last updated 26 days ago.

infrastructure datarepresentation dataimport sequencing rnaseq coverage annotation genomeannotation singlecell immunooncology bioconductor-package core-package u24ca289073

10.0 match 12 stars 13.19 score 844 scripts 123 dependents

europeanifcbgroup

iRfcb:Tools for Managing Imaging FlowCytobot (IFCB) Data

A comprehensive suite of tools for managing, processing, and analyzing data from the IFCB. I R FlowCytobot ('iRfcb') supports quality control, geospatial analysis, and preparation of IFCB data for publication in databases like <https://www.gbif.org>, <https://www.obis.org>, <https://emodnet.ec.europa.eu/en>, <https://shark.smhi.se/>, and <https://www.ecotaxa.org>. The package integrates with the MATLAB 'ifcb-analysis' tool, which is described in Sosik and Olson (2007) <doi:10.4319/lom.2007.5.204>, and provides features for working with raw, manually classified, and machine learning–classified image datasets. Key functionalities include image extraction, particle size distribution analysis, taxonomic data handling, and biomass concentration calculations, essential for plankton research.

Maintained by Anders Torstensson. Last updated 9 hours ago.

22.5 match 1 stars 5.72 score

david-barnett

microViz:Microbiome Data Analysis and Visualization

Microbiome data visualization and statistics tools built upon phyloseq.

Maintained by David Barnett. Last updated 3 months ago.

microbiome microbiome-analysis microbiota

20.6 match 114 stars 6.22 score 480 scripts

bioc

cliqueMS:Annotation of Isotopes, Adducts and Fragmentation Adducts for in-Source LC/MS Metabolomics Data

Annotates data from liquid chromatography coupled to mass spectrometry (LC/MS) metabolomics experiments. Based on a network algorithm (O.Senan, A. Aguilar- Mogas, M. Navarro, O. Yanes, R.Guimerà and M. Sales-Pardo, Bioinformatics, 35(20), 2019), 'CliqueMS' builds a weighted similarity network where nodes are features and edges are weighted according to the similarity of this features. Then it searches for the most plausible division of the similarity network into cliques (fully connected components). Finally it annotates metabolites within each clique, obtaining for each annotated metabolite the neutral mass and their features, corresponding to isotopes, ionization adducts and fragmentation adducts of that metabolite.

Maintained by Oriol Senan Campos. Last updated 5 months ago.

metabolomics massspectrometry network networkinference cpp

18.4 match 12 stars 6.91 score 25 scripts

thomasp85

ggforce:Accelerating 'ggplot2'

The aim of 'ggplot2' is to aid in visual data investigations. This focus has led to a lack of facilities for composing specialised plots. 'ggforce' aims to be a collection of mainly new stats and geoms that fills this gap. All additional functionality is aimed to come through the official extension system so using 'ggforce' should be a stable experience.

Maintained by Thomas Lin Pedersen. Last updated 1 years ago.

ggplot-extension ggplot2 visualization cpp

8.0 match 920 stars 15.83 score 9.3k scripts 293 dependents

bioc

ChromSCape:Analysis of single-cell epigenomics datasets with a Shiny App

ChromSCape - Chromatin landscape profiling for Single Cells - is a ready-to-launch user-friendly Shiny Application for the analysis of single-cell epigenomics datasets (scChIP-seq, scATAC-seq, scCUT&Tag, ...) from aligned data to differential analysis & gene set enrichment analysis. It is highly interactive, enables users to save their analysis and covers a wide range of analytical steps: QC, preprocessing, filtering, batch correction, dimensionality reduction, vizualisation, clustering, differential analysis and gene set analysis.

Maintained by Pacome Prompsy. Last updated 5 months ago.

shinyapps software singlecell chipseq atacseq methylseq classification clustering epigenetics principalcomponent annotation batcheffect multiplecomparison normalization pathways preprocessing qualitycontrol reportwriting visualization genesetenrichment differentialpeakcalling epigenomics shiny single-cell cpp

21.7 match 14 stars 5.83 score 16 scripts

bioc

LOLA:Locus overlap analysis for enrichment of genomic ranges

Provides functions for testing overlap of sets of genomic regions with public and custom region set (genomic ranges) databases. This makes it possible to do automated enrichment analysis for genomic region sets, thus facilitating interpretation of functional genomics and epigenomics data.

Maintained by Nathan Sheffield. Last updated 5 months ago.

genesetenrichment generegulation genomeannotation systemsbiology functionalgenomics chipseq methylseq sequencing

13.4 match 76 stars 9.34 score 160 scripts

wilkelab

cowplot:Streamlined Plot Theme and Plot Annotations for 'ggplot2'

Provides various features that help with creating publication-quality figures with 'ggplot2', such as a set of themes, functions to align plots and arrange them into complex compound figures, and functions that make it easy to annotate plots and or mix plots with images. The package was originally written for internal use in the Wilke lab, hence the name (Claus O. Wilke's plot package). It has also been used extensively in the book Fundamentals of Data Visualization.

Maintained by Claus O. Wilke. Last updated 2 months ago.

6.6 match 714 stars 18.83 score 75k scripts 1.4k dependents

ropensci

treeio:Base Classes and Functions for Phylogenetic Tree Input and Output

'treeio' is an R package to make it easier to import and store phylogenetic tree with associated data; and to link external data from different sources to phylogeny. It also supports exporting phylogenetic tree with heterogeneous associated data to a single tree file and can be served as a platform for merging tree with associated data and converting file formats.

Maintained by Guangchuang Yu. Last updated 5 months ago.

software annotation clustering dataimport datarepresentation alignment multiplesequencealignment phylogenetics exporter parser phylogenetic-trees

10.0 match 102 stars 12.46 score 1.3k scripts 122 dependents

bioc

annotationTools:Annotate microarrays and perform cross-species gene expression analyses using flat file databases

Functions to annotate microarrays, find orthologs, and integrate heterogeneous gene expression profiles using annotation and other molecular biology information available as flat file database (plain text files).

Maintained by Alexandre Kuhn. Last updated 5 months ago.

microarray annotation

27.5 match 4.51 score 18 scripts 1 dependents

bioc

ReactomePA:Reactome Pathway Analysis

This package provides functions for pathway analysis based on REACTOME pathway database. It implements enrichment analysis, gene set enrichment analysis and several functions for visualization. This package is not affiliated with the Reactome team.

Maintained by Guangchuang Yu. Last updated 5 months ago.

pathways visualization annotation multiplecomparison genesetenrichment reactome enrichment-analysis reactome-pathway-analysis reactomepa

10.0 match 40 stars 12.25 score 1.5k scripts 7 dependents

bioc

sitadela:An R package for the easy provision of simple but complete tab-delimited genomic annotation from a variety of sources and organisms

Provides an interface to build a unified database of genomic annotations and their coordinates (gene, transcript and exon levels). It is aimed to be used when simple tab-delimited annotations (or simple GRanges objects) are required instead of the more complex annotation Bioconductor packages. Also useful when combinatorial annotation elements are reuired, such as RefSeq coordinates with Ensembl biotypes. Finally, it can download, construct and handle annotations with versioned genes and transcripts (where available, e.g. RefSeq and latest Ensembl). This is particularly useful in precision medicine applications where the latter must be reported.

Maintained by Panagiotis Moulos. Last updated 5 months ago.

software workflowstep rnaseq transcription sequencing transcriptomics biomedicalinformatics functionalgenomics systemsbiology alternativesplicing dataimport chipseq

26.6 match 4.60 score 2 scripts

tomkellygenetics

vioplot:Violin Plot

A violin plot is a combination of a box plot and a kernel density plot. This package allows extensive customisation of violin plots.

Maintained by S. Thomas Kelly. Last updated 21 days ago.

boxplot colours customisation dataviz formula plotting violin-plot violinplot vioplot

9.8 match 26 stars 12.32 score 2.0k scripts 8 dependents

pascalcroteau

matrixset:Creating, Manipulating and Annotating Matrix Ensemble

Creates an object that stores a matrix ensemble, matrices that share the same common properties, where rows and columns can be annotated. Matrices must have the same dimension and dimnames. Operators to manipulate these objects are provided as well as mechanisms to apply functions to these objects.

Maintained by Pascal Croteau. Last updated 2 months ago.

cpp

23.6 match 2 stars 5.12 score 11 scripts

bioc

Biobase:Biobase: Base functions for Bioconductor

Functions that are needed by many other packages or which replace R functions.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

infrastructure bioconductor-package core-package

7.3 match 9 stars 16.45 score 6.6k scripts 1.8k dependents

bioc

geneXtendeR:Optimized Functional Annotation Of ChIP-seq Data

geneXtendeR optimizes the functional annotation of ChIP-seq peaks by exploring relative differences in annotating ChIP-seq peak sets to variable-length gene bodies. In contrast to prior techniques, geneXtendeR considers peak annotations beyond just the closest gene, allowing users to see peak summary statistics for the first-closest gene, second-closest gene, ..., n-closest gene whilst ranking the output according to biologically relevant events and iteratively comparing the fidelity of peak-to-gene overlap across a user-defined range of upstream and downstream extensions on the original boundaries of each gene's coordinates. Since different ChIP-seq peak callers produce different differentially enriched peaks with a large variance in peak length distribution and total peak count, annotating peak lists with their nearest genes can often be a noisy process. As such, the goal of geneXtendeR is to robustly link differentially enriched peaks with their respective genes, thereby aiding experimental follow-up and validation in designing primers for a set of prospective gene candidates during qPCR.

Maintained by Bohdan Khomtchouk. Last updated 5 months ago.

chipseq genetics annotation genomeannotation differentialpeakcalling coverage peakdetection chiponchip histonemodification dataimport naturallanguageprocessing visualization go software bioconductor bioinformatics c chip-seq computational-biology epigenetics functional-annotation

30.2 match 9 stars 3.95 score 5 scripts

bioc

minfi:Analyze Illumina Infinium DNA methylation arrays

Tools to analyze & visualize Illumina Infinium methylation arrays.

Maintained by Kasper Daniel Hansen. Last updated 4 months ago.

immunooncology dnamethylation differentialmethylation epigenetics microarray methylationarray multichannel twochannel dataimport normalization preprocessing qualitycontrol

9.3 match 60 stars 12.83 score 996 scripts 26 dependents

bioc

metaseqR2:An R package for the analysis and result reporting of RNA-Seq data by combining multiple statistical algorithms

Provides an interface to several normalization and statistical testing packages for RNA-Seq gene expression data. Additionally, it creates several diagnostic plots, performs meta-analysis by combinining the results of several statistical tests and reports the results in an interactive way.

Maintained by Panagiotis Moulos. Last updated 5 days ago.

software geneexpression differentialexpression workflowstep preprocessing qualitycontrol normalization reportwriting rnaseq transcription sequencing transcriptomics bayesian clustering cellbiology biomedicalinformatics functionalgenomics systemsbiology immunooncology alternativesplicing differentialsplicing multiplecomparison timecourse dataimport atacseq epigenetics regression proprietaryplatforms genesetenrichment batcheffect chipseq

19.5 match 7 stars 6.05 score 3 scripts

bioc

annaffy:Annotation tools for Affymetrix biological metadata

Functions for handling data from Bioconductor Affymetrix annotation data packages. Produces compact HTML and text reports including experimental data and URL links to many online databases. Allows searching biological metadata using various criteria.

Maintained by Colin A. Smith. Last updated 5 months ago.

onechannel microarray annotation go pathways reportwriting

20.9 match 5.64 score 60 scripts 3 dependents

bioc

proActiv:Estimate Promoter Activity from RNA-Seq data

Most human genes have multiple promoters that control the expression of different isoforms. The use of these alternative promoters enables the regulation of isoform expression pre-transcriptionally. Alternative promoters have been found to be important in a wide number of cell types and diseases. proActiv is an R package that enables the analysis of promoters from RNA-seq data. proActiv uses aligned reads as input, and generates counts and normalized promoter activity estimates for each annotated promoter. In particular, proActiv accepts junction files from TopHat2 or STAR or BAM files as inputs. These estimates can then be used to identify which promoter is active, which promoter is inactive, and which promoters change their activity across conditions. proActiv also allows visualization of promoter activity across conditions.

Maintained by Joseph Lee. Last updated 5 months ago.

rnaseq geneexpression transcription alternativesplicing generegulation differentialsplicing functionalgenomics epigenetics transcriptomics preprocessing alternative-promoters genomics promoter-activity promoter-annotation rna-seq-data

17.6 match 51 stars 6.66 score 15 scripts

bioc

cola:A Framework for Consensus Partitioning

Subgroup classification is a basic task in genomic data analysis, especially for gene expression and DNA methylation data analysis. It can also be used to test the agreement to known clinical annotations, or to test whether there exist significant batch effects. The cola package provides a general framework for subgroup classification by consensus partitioning. It has the following features: 1. It modularizes the consensus partitioning processes that various methods can be easily integrated. 2. It provides rich visualizations for interpreting the results. 3. It allows running multiple methods at the same time and provides functionalities to straightforward compare results. 4. It provides a new method to extract features which are more efficient to separate subgroups. 5. It automatically generates detailed reports for the complete analysis. 6. It allows applying consensus partitioning in a hierarchical manner.

Maintained by Zuguang Gu. Last updated 1 months ago.

clustering geneexpression classification software consensus-clustering cpp

15.5 match 61 stars 7.49 score 112 scripts

bioc

simona:Semantic Similarity on Bio-Ontologies

This package implements infrastructures for ontology analysis by offering efficient data structures, fast ontology traversal methods, and elegant visualizations. It provides a robust toolbox supporting over 70 methods for semantic similarity analysis.

Maintained by Zuguang Gu. Last updated 5 months ago.

software annotation go biomedicalinformatics cpp

17.5 match 16 stars 6.59 score 27 scripts 1 dependents

bioc

recount3:Explore and download data from the recount3 project

The recount3 package enables access to a large amount of uniformly processed RNA-seq data from human and mouse. You can download RangedSummarizedExperiment objects at the gene, exon or exon-exon junctions level with sample metadata and QC statistics. In addition we provide access to sample coverage BigWig files.

Maintained by Leonardo Collado-Torres. Last updated 3 months ago.

coverage differentialexpression geneexpression rnaseq sequencing software dataimport annotation-agnostic bioconductor count derfinder exon gene human illumina junction mouse recount recount3

14.3 match 33 stars 8.03 score 216 scripts

bioc

GenomicInteractions:Utilities for handling genomic interaction data

Utilities for handling genomic interaction data such as ChIA-PET or Hi-C, annotating genomic features with interaction information, and producing plots and summary statistics.

Maintained by Liz Ing-Simmons. Last updated 5 months ago.

software infrastructure dataimport datarepresentation hic

12.1 match 7 stars 9.39 score 162 scripts 6 dependents

bioc

BiocGenerics:S4 generic functions used in Bioconductor

The package defines many S4 generic functions used in Bioconductor.

Maintained by Hervé Pagès. Last updated 1 months ago.

infrastructure bioconductor-package core-package

8.0 match 12 stars 14.22 score 612 scripts 2.2k dependents

aphalo

ggpp:Grammar Extensions to 'ggplot2'

Extensions to 'ggplot2' respecting the grammar of graphics paradigm. Geometries: geom_table(), geom_plot() and geom_grob() add insets to plots using native data coordinates, while geom_table_npc(), geom_plot_npc() and geom_grob_npc() do the same using "npc" coordinates through new aesthetics "npcx" and "npcy". Statistics: select observations based on 2D density. Positions: radial nudging away from a center point and nudging away from a line or curve; combined stacking and nudging; combined dodging and nudging.

Maintained by Pedro J. Aphalo. Last updated 21 days ago.

data-labels dataviz ggplot2-enhancements ggplot2-geoms ggplot2-insets ggplot2-positions

9.1 match 130 stars 12.49 score 582 scripts 24 dependents

bioc

PharmacoGx:Analysis of Large-Scale Pharmacogenomic Data

Contains a set of functions to perform large-scale analysis of pharmaco-genomic data. These include the PharmacoSet object for storing the results of pharmacogenomic experiments, as well as a number of functions for computing common summaries of drug-dose response and correlating them with the molecular features in a cancer cell-line.

Maintained by Benjamin Haibe-Kains. Last updated 2 months ago.

geneexpression pharmacogenetics pharmacogenomics software classification datasets pharmacogenomic pharmacogx cpp

9.9 match 68 stars 11.39 score 442 scripts 3 dependents

bioc

beadarray:Quality assessment and low-level analysis for Illumina BeadArray data

The package is able to read bead-level data (raw TIFFs and text files) output by BeadScan as well as bead-summary data from BeadStudio. Methods for quality assessment and low-level analysis are provided.

Maintained by Mark Dunning. Last updated 5 months ago.

microarray onechannel qualitycontrol preprocessing

14.0 match 7.88 score 70 scripts 4 dependents

davidgohel

ggiraph:Make 'ggplot2' Graphics Interactive

Create interactive 'ggplot2' graphics using 'htmlwidgets'.

Maintained by David Gohel. Last updated 3 months ago.

libpng cpp

7.5 match 819 stars 14.39 score 4.1k scripts 34 dependents

bioc

GenomicScores:Infrastructure to work with genomewide position-specific scores

Provide infrastructure to store and access genomewide position-specific scores within R and Bioconductor.

Maintained by Robert Castelo. Last updated 1 months ago.

infrastructure genetics annotation sequencing coverage annotationhubsoftware

12.4 match 8 stars 8.71 score 83 scripts 6 dependents

bioc

ggmsa:Plot Multiple Sequence Alignment using 'ggplot2'

A visual exploration tool for multiple sequence alignment and associated data. Supports MSA of DNA, RNA, and protein sequences using 'ggplot2'. Multiple sequence alignment can easily be combined with other 'ggplot2' plots, such as phylogenetic tree Visualized by 'ggtree', boxplot, genome map and so on. More features: visualization of sequence logos, sequence bundles, RNA secondary structures and detection of sequence recombinations.

Maintained by Guangchuang Yu. Last updated 3 months ago.

software visualization alignment annotation multiplesequencealignment

11.5 match 209 stars 9.34 score 196 scripts 2 dependents

rickhelmus

patRoon:Workflows for Mass-Spectrometry Based Non-Target Analysis

Provides an easy-to-use interface to a mass spectrometry based non-target analysis workflow. Various (open-source) tools are combined which provide algorithms for extraction and grouping of features, extraction of MS and MS/MS data, automatic formula and compound annotation and grouping related features to components. In addition, various tools are provided for e.g. data preparation and cleanup, plotting results and automatic reporting.

Maintained by Rick Helmus. Last updated 10 days ago.

mass-spectrometry non-target cpp openjdk

17.3 match 65 stars 6.22 score 43 scripts

bioc

tximeta:Transcript Quantification Import with Automatic Metadata

Transcript quantification import from Salmon and other quantifiers with automatic attachment of transcript ranges and release information, and other associated metadata. De novo transcriptomes can be linked to the appropriate sources with linkedTxomes and shared for computational reproducibility.

Maintained by Michael Love. Last updated 2 months ago.

annotation genomeannotation dataimport preprocessing rnaseq singlecell transcriptomics transcription geneexpression functionalgenomics reproducibleresearch reportwriting immunooncology

10.0 match 67 stars 10.58 score 466 scripts 1 dependents

bioc

OmaDB:R wrapper for the OMA REST API

A package for the orthology prediction data download from OMA database.

Maintained by Klara Kaleb. Last updated 5 months ago.

software comparativegenomics functionalgenomics genetics annotation go functionalprediction

17.0 match 2 stars 6.23 score 5 scripts

bioc

SWATH2stats:Transform and Filter SWATH Data for Statistical Packages

This package is intended to transform SWATH data from the OpenSWATH software into a format readable by other statistics packages while performing filtering, annotation and FDR estimation.

Maintained by Peter Blattmann. Last updated 5 months ago.

proteomics annotation experimentaldesign preprocessing massspectrometry immunooncology

16.8 match 1 stars 6.30 score 22 scripts

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NetPathMiner:NetPathMiner for Biological Network Construction, Path Mining and Visualization

NetPathMiner is a general framework for network path mining using genome-scale networks. It constructs networks from KGML, SBML and BioPAX files, providing three network representations, metabolic, reaction and gene representations. NetPathMiner finds active paths and applies machine learning methods to summarize found paths for easy interpretation. It also provides static and interactive visualizations of networks and paths to aid manual investigation.

Maintained by Ahmed Mohamed. Last updated 4 months ago.

graphandnetwork pathways network clustering classification libsbml libxml2 openblas cpp

16.1 match 9 stars 6.56 score 9 scripts

bioc

scRepertoire:A toolkit for single-cell immune receptor profiling

scRepertoire is a toolkit for processing and analyzing single-cell T-cell receptor (TCR) and immunoglobulin (Ig). The scRepertoire framework supports use of 10x, AIRR, BD, MiXCR, Omniscope, TRUST4, and WAT3R single-cell formats. The functionality includes basic clonal analyses, repertoire summaries, distance-based clustering and interaction with the popular Seurat and SingleCellExperiment/Bioconductor R workflows.

Maintained by Nick Borcherding. Last updated 2 months ago.

software immunooncology singlecell classification annotation sequencing cpp

10.0 match 326 stars 10.49 score 240 scripts

bioc

customCMPdb:Customize and Query Compound Annotation Database

This package serves as a query interface for important community collections of small molecules, while also allowing users to include custom compound collections.

Maintained by Yuzhu Duan. Last updated 5 months ago.

software cheminformatics annotationhubsoftware

21.5 match 2 stars 4.78 score 4 scripts

bioc

BiocIO:Standard Input and Output for Bioconductor Packages

The `BiocIO` package contains high-level abstract classes and generics used by developers to build IO funcionality within the Bioconductor suite of packages. Implements `import()` and `export()` standard generics for importing and exporting biological data formats. `import()` supports whole-file as well as chunk-wise iterative import. The `import()` interface optionally provides a standard mechanism for 'lazy' access via `filter()` (on row or element-like components of the file resource), `select()` (on column-like components of the file resource) and `collect()`. The `import()` interface optionally provides transparent access to remote (e.g. via https) as well as local access. Developers can register a file extension, e.g., `.loom` for dispatch from character-based URIs to specific `import()` / `export()` methods based on classes representing file types, e.g., `LoomFile()`.

Maintained by Marcel Ramos. Last updated 4 months ago.

annotation dataimport bioconductor-package core-package

10.0 match 1 stars 10.20 score 19 scripts 487 dependents

bioc

SGSeq:Splice event prediction and quantification from RNA-seq data

SGSeq is a software package for analyzing splice events from RNA-seq data. Input data are RNA-seq reads mapped to a reference genome in BAM format. Genes are represented as a splice graph, which can be obtained from existing annotation or predicted from the mapped sequence reads. Splice events are identified from the graph and are quantified locally using structurally compatible reads at the start or end of each splice variant. The software includes functions for splice event prediction, quantification, visualization and interpretation.

Maintained by Leonard Goldstein. Last updated 5 months ago.

alternativesplicing immunooncology rnaseq transcription

17.1 match 5.91 score 45 scripts 3 dependents

bioc

atena:Analysis of Transposable Elements

Quantify expression of transposable elements (TEs) from RNA-seq data through different methods, including ERVmap, TEtranscripts and Telescope. A common interface is provided to use each of these methods, which consists of building a parameter object, calling the quantification function with this object and getting a SummarizedExperiment object as output container of the quantified expression profiles. The implementation allows one to quantify TEs and gene transcripts in an integrated manner.

Maintained by Robert Castelo. Last updated 1 months ago.

transcription transcriptomics rnaseq sequencing preprocessing software geneexpression coverage differentialexpression functionalgenomics

16.4 match 10 stars 6.18 score 1 scripts

bioc

UCSC.utils:Low-level utilities to retrieve data from the UCSC Genome Browser

A set of low-level utilities to retrieve data from the UCSC Genome Browser. Most functions in the package access the data via the UCSC REST API but some of them query the UCSC MySQL server directly. Note that the primary purpose of the package is to support higher-level functionalities implemented in downstream packages like GenomeInfoDb or txdbmaker.

Maintained by Hervé Pagès. Last updated 2 months ago.

infrastructure genomeassembly annotation genomeannotation dataimport bioconductor-package core-package

10.0 match 1 stars 10.09 score 4 scripts 1.7k dependents

bioc

CatsCradle:This package provides methods for analysing spatial transcriptomics data and for discovering gene clusters

This package addresses two broad areas. It allows for in-depth analysis of spatial transcriptomic data by identifying tissue neighbourhoods. These are contiguous regions of tissue surrounding individual cells. 'CatsCradle' allows for the categorisation of neighbourhoods by the cell types contained in them and the genes expressed in them. In particular, it produces Seurat objects whose individual elements are neighbourhoods rather than cells. In addition, it enables the categorisation and annotation of genes by producing Seurat objects whose elements are genes.

Maintained by Michael Shapiro. Last updated 1 months ago.

biologicalquestion statisticalmethod geneexpression singlecell transcriptomics spatial

15.4 match 3 stars 6.50 score

bioc

csaw:ChIP-Seq Analysis with Windows

Detection of differentially bound regions in ChIP-seq data with sliding windows, with methods for normalization and proper FDR control.

Maintained by Aaron Lun. Last updated 2 months ago.

multiplecomparison chipseq normalization sequencing coverage genetics annotation differentialpeakcalling curl bzip2 xz-utils zlib cpp

12.0 match 8.32 score 498 scripts 7 dependents

pyanglab

directPA:Direction Analysis for Pathways and Kinases

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

Maintained by Pengyi Yang. Last updated 1 years ago.

24.0 match 4.14 score 31 scripts 1 dependents

sistm

cytometree:Automated Cytometry Gating and Annotation

Given the hypothesis of a bi-modal distribution of cells for each marker, the algorithm constructs a binary tree, the nodes of which are subpopulations of cells. At each node, observed cells and markers are modeled by both a family of normal distributions and a family of bi-modal normal mixture distributions. Splitting is done according to a normalized difference of AIC between the two families. Method is detailed in: Commenges, Alkhassim, Gottardo, Hejblum & Thiebaut (2018) <doi: 10.1002/cyto.a.23601>.

Maintained by Boris P Hejblum. Last updated 2 years ago.

cpp

16.8 match 9 stars 5.91 score 15 scripts 1 dependents

bioc

MSstatsShiny:MSstats GUI for Statistical Anaylsis of Proteomics Experiments

MSstatsShiny is an R-Shiny graphical user interface (GUI) integrated with the R packages MSstats, MSstatsTMT, and MSstatsPTM. It provides a point and click end-to-end analysis pipeline applicable to a wide variety of experimental designs. These include data-dependedent acquisitions (DDA) which are label-free or tandem mass tag (TMT)-based, as well as DIA, SRM, and PRM acquisitions and those targeting post-translational modifications (PTMs). The application automatically saves users selections and builds an R script that recreates their analysis, supporting reproducible data analysis.

Maintained by Devon Kohler. Last updated 5 months ago.

immunooncology massspectrometry proteomics software shinyapps differentialexpression onechannel twochannel normalization qualitycontrol gui

15.3 match 15 stars 6.43 score 4 scripts

bioc

ggtreeExtra:An R Package To Add Geometric Layers On Circular Or Other Layout Tree Of "ggtree"

'ggtreeExtra' extends the method for mapping and visualizing associated data on phylogenetic tree using 'ggtree'. These associated data can be presented on the external panels to circular layout, fan layout, or other rectangular layout tree built by 'ggtree' with the grammar of 'ggplot2'.

Maintained by Shuangbin Xu. Last updated 5 months ago.

software visualization phylogenetics annotation

10.0 match 90 stars 9.72 score 426 scripts 3 dependents

oliverehmer

act:Aligned Corpus Toolkit

The Aligned Corpus Toolkit (act) is designed for linguists that work with time aligned transcription data. It offers functions to import and export various annotation file formats ('ELAN' .eaf, 'EXMARaLDA .exb and 'Praat' .TextGrid files), create print transcripts in the style of conversation analysis, search transcripts (span searches across multiple annotations, search in normalized annotations, make concordances etc.), export and re-import search results (.csv and 'Excel' .xlsx format), create cuts for the search results (print transcripts, audio/video cuts using 'FFmpeg' and video sub titles in 'Subrib title' .srt format), modify the data in a corpus (search/replace, delete, filter etc.), interact with 'Praat' using 'Praat'-scripts, and exchange data with the 'rPraat' package. The package is itself written in R and may be expanded by other users.

Maintained by Oliver Ehmer. Last updated 2 years ago.

14.6 match 4 stars 6.65 score 184 scripts

bioc

scp:Mass Spectrometry-Based Single-Cell Proteomics Data Analysis

Utility functions for manipulating, processing, and analyzing mass spectrometry-based single-cell proteomics data. The package is an extension to the 'QFeatures' package and relies on 'SingleCellExpirement' to enable single-cell proteomics analyses. The package offers the user the functionality to process quantitative table (as generated by MaxQuant, Proteome Discoverer, and more) into data tables ready for downstream analysis and data visualization.

Maintained by Christophe Vanderaa. Last updated 16 days ago.

geneexpression proteomics singlecell massspectrometry preprocessing cellbasedassays bioconductor mass-spectrometry single-cell software

10.9 match 25 stars 8.94 score 115 scripts

bioc

goseq:Gene Ontology analyser for RNA-seq and other length biased data

Detects Gene Ontology and/or other user defined categories which are over/under represented in RNA-seq data.

Maintained by Federico Marini. Last updated 5 months ago.

immunooncology sequencing go geneexpression transcription rnaseq differentialexpression annotation genesetenrichment kegg pathways software

10.0 match 1 stars 9.67 score 636 scripts 9 dependents

bioc

SCANVIS:SCANVIS - a tool for SCoring, ANnotating and VISualizing splice junctions

SCANVIS is a set of annotation-dependent tools for analyzing splice junctions and their read support as predetermined by an alignment tool of choice (for example, STAR aligner). SCANVIS assesses each junction's relative read support (RRS) by relating to the context of local split reads aligning to annotated transcripts. SCANVIS also annotates each splice junction by indicating whether the junction is supported by annotation or not, and if not, what type of junction it is (e.g. exon skipping, alternative 5' or 3' events, Novel Exons). Unannotated junctions are also futher annotated by indicating whether it induces a frame shift or not. SCANVIS includes a visualization function to generate static sashimi-style plots depicting relative read support and number of split reads using arc thickness and arc heights, making it easy for users to spot well-supported junctions. These plots also clearly delineate unannotated junctions from annotated ones using designated color schemes, and users can also highlight splice junctions of choice. Variants and/or a read profile are also incoroporated into the plot if the user supplies variants in bed format and/or the BAM file. One further feature of the visualization function is that users can submit multiple samples of a certain disease or cohort to generate a single plot - this occurs via a "merge" function wherein junction details over multiple samples are merged to generate a single sashimi plot, which is useful when contrasting cohorots (eg. disease vs control).

Maintained by Phaedra Agius. Last updated 5 months ago.

software researchfield transcriptomics workflowstep annotation visualization

24.1 match 4.00 score 2 scripts

bioc

clustifyr:Classifier for Single-cell RNA-seq Using Cell Clusters

Package designed to aid in classifying cells from single-cell RNA sequencing data using external reference data (e.g., bulk RNA-seq, scRNA-seq, microarray, gene lists). A variety of correlation based methods and gene list enrichment methods are provided to assist cell type assignment.

Maintained by Rui Fu. Last updated 5 months ago.

singlecell annotation sequencing microarray geneexpression assign-identities clusters marker-genes rna-seq single-cell-rna-seq

10.0 match 119 stars 9.63 score 296 scripts

bioc

raer:RNA editing tools in R

Toolkit for identification and statistical testing of RNA editing signals from within R. Provides support for identifying sites from bulk-RNA and single cell RNA-seq datasets, and general methods for extraction of allelic read counts from alignment files. Facilitates annotation and exploratory analysis of editing signals using Bioconductor packages and resources.

Maintained by Kent Riemondy. Last updated 5 months ago.

multiplecomparison rnaseq singlecell sequencing coverage epitranscriptomics featureextraction annotation alignment bioconductor-package rna-seq-analysis single-cell-analysis single-cell-rna-seq curl bzip2 xz-utils zlib

15.9 match 8 stars 5.98 score 6 scripts

bioc

StructuralVariantAnnotation:Variant annotations for structural variants

StructuralVariantAnnotation provides a framework for analysis of structural variants within the Bioconductor ecosystem. This package contains contains useful helper functions for dealing with structural variants in VCF format. The packages contains functions for parsing VCFs from a number of popular callers as well as functions for dealing with breakpoints involving two separate genomic loci encoded as GRanges objects.

Maintained by Daniel Cameron. Last updated 5 months ago.

dataimport sequencing annotation genetics variantannotation

15.0 match 6.26 score 102 scripts 2 dependents

bioc

Gviz:Plotting data and annotation information along genomic coordinates

Genomic data analyses requires integrated visualization of known genomic information and new experimental data. Gviz uses the biomaRt and the rtracklayer packages to perform live annotation queries to Ensembl and UCSC and translates this to e.g. gene/transcript structures in viewports of the grid graphics package. This results in genomic information plotted together with your data.

Maintained by Robert Ivanek. Last updated 5 months ago.

visualization microarray sequencing

7.1 match 79 stars 13.08 score 1.4k scripts 48 dependents

bioc

Organism.dplyr:dplyr-based Access to Bioconductor Annotation Resources

This package provides an alternative interface to Bioconductor 'annotation' resources, in particular the gene identifier mapping functionality of the 'org' packages (e.g., org.Hs.eg.db) and the genome coordinate functionality of the 'TxDb' packages (e.g., TxDb.Hsapiens.UCSC.hg38.knownGene).

Maintained by Martin Morgan. Last updated 5 months ago.

annotation sequencing genomeannotation bioconductor-package core-package

13.4 match 3 stars 6.77 score 63 scripts 1 dependents

bioc

BgeeDB:Annotation and gene expression data retrieval from Bgee database. TopAnat, an anatomical entities Enrichment Analysis tool for UBERON ontology

A package for the annotation and gene expression data download from Bgee database, and TopAnat analysis: GO-like enrichment of anatomical terms, mapped to genes by expression patterns.

Maintained by Julien Wollbrett. Last updated 5 months ago.

software dataimport sequencing geneexpression microarray go genesetenrichment bioinformatics enrichment-analysis rna-seq scrna-seq single-cell

10.7 match 15 stars 8.46 score 19 scripts 1 dependents

bioc

GOstats:Tools for manipulating GO and microarrays

A set of tools for interacting with GO and microarray data. A variety of basic manipulation tools for graphs, hypothesis testing and other simple calculations.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation go multiplecomparison geneexpression microarray pathways genesetenrichment graphandnetwork

13.0 match 6.93 score 528 scripts 12 dependents

bioc

AlphaMissenseR:Accessing AlphaMissense Data Resources in R

The AlphaMissense publication <https://www.science.org/doi/epdf/10.1126/science.adg7492> outlines how a variant of AlphaFold / DeepMind was used to predict missense variant pathogenicity. Supporting data on Zenodo <https://zenodo.org/record/10813168> include, for instance, 71M variants across hg19 and hg38 genome builds. The 'AlphaMissenseR' package allows ready access to the data, downloading individual files to DuckDB databases for exploration and integration into *R* and *Bioconductor* workflows.

Maintained by Martin Morgan. Last updated 5 months ago.

snp annotation functionalgenomics structuralprediction transcriptomics variantannotation geneprediction immunooncology

13.1 match 8 stars 6.86 score 10 scripts

zjufanlab

scCATCH:Single Cell Cluster-Based Annotation Toolkit for Cellular Heterogeneity

An automatic cluster-based annotation pipeline based on evidence-based score by matching the marker genes with known cell markers in tissue-specific cell taxonomy reference database for single-cell RNA-seq data. See Shao X, et al (2020) <doi:10.1016/j.isci.2020.100882> for more details.

Maintained by Xin Shao. Last updated 2 years ago.

cell-markers cluster-annotation marker-genes rna-seq sequencing seurat single-cell transcriptome transcriptomics

12.6 match 225 stars 7.13 score 75 scripts

bioc

mygene:Access MyGene.Info_ services

MyGene.Info_ provides simple-to-use REST web services to query/retrieve gene annotation data. It's designed with simplicity and performance emphasized. *mygene*, is an easy-to-use R wrapper to access MyGene.Info_ services.

Maintained by Adam Mark, Cyrus Afrasiabi, Chunlei Wu. Last updated 5 months ago.

annotation

12.3 match 7.17 score 330 scripts 1 dependents

bioc

UniProt.ws:R Interface to UniProt Web Services

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. This package provides a collection of functions for retrieving, processing, and re-packaging UniProt web services. The package makes use of UniProt's modernized REST API and allows mapping of identifiers accross different databases.

Maintained by Marcel Ramos. Last updated 2 months ago.

annotation infrastructure go kegg biocarta bioconductor-package core-package

10.5 match 4 stars 8.38 score 167 scripts 4 dependents

ms609

Ternary:Create Ternary and Holdridge Plots

Plots ternary diagrams (simplex plots / Gibbs triangles) and Holdridge life zone plots <doi:10.1126/science.105.2727.367> using the standard graphics functions. Allows custom annotation, interpolating, contouring and scaling of plotting region. Includes a 'Shiny' user interface for point-and-click ternary plotting. An alternative to 'ggtern', which uses the 'ggplot2' family of plotting functions.

Maintained by Martin R. Smith. Last updated 5 months ago.

graphics plotting plotting-in-r ternary-plots

9.1 match 33 stars 9.58 score 103 scripts 5 dependents

bioc

cellbaseR:Querying annotation data from the high performance Cellbase web

This R package makes use of the exhaustive RESTful Web service API that has been implemented for the Cellabase database. It enable researchers to query and obtain a wealth of biological information from a single database saving a lot of time. Another benefit is that researchers can easily make queries about different biological topics and link all this information together as all information is integrated.

Maintained by Mohammed OE Abdallah. Last updated 5 months ago.

annotation variantannotation

16.0 match 2 stars 5.48 score 6 scripts

bioc

cogeqc:Systematic quality checks on comparative genomics analyses

cogeqc aims to facilitate systematic quality checks on standard comparative genomics analyses to help researchers detect issues and select the most suitable parameters for each data set. cogeqc can be used to asses: i. genome assembly and annotation quality with BUSCOs and comparisons of statistics with publicly available genomes on the NCBI; ii. orthogroup inference using a protein domain-based approach and; iii. synteny detection using synteny network properties. There are also data visualization functions to explore QC summary statistics.

Maintained by Fabrício Almeida-Silva. Last updated 5 months ago.

software genomeassembly comparativegenomics functionalgenomics phylogenetics qualitycontrol network comparative-genomics evolutionary-genomics

14.2 match 10 stars 6.08 score 20 scripts

bioc

EnrichDO:a Global Weighted Model for Disease Ontology Enrichment Analysis

To implement disease ontology (DO) enrichment analysis, this package is designed and presents a double weighted model based on the latest annotations of the human genome with DO terms, by integrating the DO graph topology on a global scale. This package exhibits high accuracy that it can identify more specific DO terms, which alleviates the over enriched problem. The package includes various statistical models and visualization schemes for discovering the associations between genes and diseases from biological big data.

Maintained by Hongyu Fu. Last updated 4 months ago.

annotation visualization genesetenrichment software

18.1 match 4.74 score 9 scripts

jbgruber

rollama:Communicate with 'Ollama' to Run Large Language Models Locally

Wraps the 'Ollama' <https://ollama.com> API, which can be used to communicate with generative large language models locally.

Maintained by Johannes B. Gruber. Last updated 1 months ago.

10.3 match 110 stars 8.36 score 52 scripts

ncss-tech

aqp:Algorithms for Quantitative Pedology

The Algorithms for Quantitative Pedology (AQP) project was started in 2009 to organize a loosely-related set of concepts and source code on the topic of soil profile visualization, aggregation, and classification into this package (aqp). Over the past 8 years, the project has grown into a suite of related R packages that enhance and simplify the quantitative analysis of soil profile data. Central to the AQP project is a new vocabulary of specialized functions and data structures that can accommodate the inherent complexity of soil profile information; freeing the scientist to focus on ideas rather than boilerplate data processing tasks <doi:10.1016/j.cageo.2012.10.020>. These functions and data structures have been extensively tested and documented, applied to projects involving hundreds of thousands of soil profiles, and deeply integrated into widely used tools such as SoilWeb <https://casoilresource.lawr.ucdavis.edu/soilweb-apps>. Components of the AQP project (aqp, soilDB, sharpshootR, soilReports packages) serve an important role in routine data analysis within the USDA-NRCS Soil Science Division. The AQP suite of R packages offer a convenient platform for bridging the gap between pedometric theory and practice.

Maintained by Dylan Beaudette. Last updated 29 days ago.

digital-soil-mapping ncss-tech nrcs pedology pedometrics soil soil-survey usda

7.3 match 55 stars 11.77 score 1.2k scripts 2 dependents

bioc

fobitools:Tools for Manipulating the FOBI Ontology

A set of tools for interacting with the Food-Biomarker Ontology (FOBI). A collection of basic manipulation tools for biological significance analysis, graphs, and text mining strategies for annotating nutritional data.

Maintained by Pol Castellano-Escuder. Last updated 4 months ago.

massspectrometry metabolomics software visualization biomedicalinformatics graphandnetwork annotation cheminformatics pathways genesetenrichment biological-intrerpretation biological-knowledge biological-significance-analysis enrichment-analysis food-biomarker-ontology knowledge-graph nutrition obofoundry ontology text-mining

16.8 match 1 stars 5.08 score 5 scripts

bioc

RMassBank:Workflow to process tandem MS files and build MassBank records

Workflow to process tandem MS files and build MassBank records. Functions include automated extraction of tandem MS spectra, formula assignment to tandem MS fragments, recalibration of tandem MS spectra with assigned fragments, spectrum cleanup, automated retrieval of compound information from Internet databases, and export to MassBank records.

Maintained by RMassBank at Eawag. Last updated 5 months ago.

immunooncology bioinformatics massspectrometry metabolomics software openjdk

13.7 match 6.19 score 26 scripts

plangfelder

WGCNA:Weighted Correlation Network Analysis

Functions necessary to perform Weighted Correlation Network Analysis on high-dimensional data as originally described in Horvath and Zhang (2005) <doi:10.2202/1544-6115.1128> and Langfelder and Horvath (2008) <doi:10.1186/1471-2105-9-559>. Includes functions for rudimentary data cleaning, construction of correlation networks, module identification, summarization, and relating of variables and modules to sample traits. Also includes a number of utility functions for data manipulation and visualization.

Maintained by Peter Langfelder. Last updated 6 months ago.

cpp

8.8 match 54 stars 9.65 score 5.3k scripts 32 dependents

hrbrmstr

ggalt:Extra Coordinate Systems, 'Geoms', Statistical Transformations, Scales and Fonts for 'ggplot2'

A compendium of new geometries, coordinate systems, statistical transformations, scales and fonts for 'ggplot2', including splines, 1d and 2d densities, univariate average shifted histograms, a new map coordinate system based on the 'PROJ.4'-library along with geom_cartogram() that mimics the original functionality of geom_map(), formatters for "bytes", a stat_stepribbon() function, increased 'plotly' compatibility and the 'StateFace' open source font 'ProPublica'. Further new functionality includes lollipop charts, dumbbell charts, the ability to encircle points and coordinate-system-based text annotations.

Maintained by Bob Rudis. Last updated 2 years ago.

geom ggplot-extension ggplot2 ggplot2-geom ggplot2-scales

6.6 match 674 stars 12.59 score 2.3k scripts 7 dependents

mpierrejean

acnr:Annotated Copy-Number Regions

This data package provides SNP array data from different types of copy-number regions. These regions were identified manually by the authors of the package and may be used to generate realistic data sets with known truth.

Maintained by Morgane Pierre-Jean. Last updated 3 years ago.

15.9 match 1 stars 5.23 score 19 scripts 3 dependents

bioc

rols:An R interface to the Ontology Lookup Service

The rols package is an interface to the Ontology Lookup Service (OLS) to access and query hundred of ontolgies directly from R.

Maintained by Laurent Gatto. Last updated 5 months ago.

immunooncology software annotation massspectrometry go

10.0 match 11 stars 8.30 score 89 scripts 5 dependents

bioc

NanoMethViz:Visualise methylation data from Oxford Nanopore sequencing

NanoMethViz is a toolkit for visualising methylation data from Oxford Nanopore sequencing. It can be used to explore methylation patterns from reads derived from Oxford Nanopore direct DNA sequencing with methylation called by callers including nanopolish, f5c and megalodon. The plots in this package allow the visualisation of methylation profiles aggregated over experimental groups and across classes of genomic features.

Maintained by Shian Su. Last updated 7 days ago.

software longread visualization differentialmethylation dnamethylation epigenetics dataimport zlib cpp

11.9 match 26 stars 6.95 score 11 scripts

bioc

GeneTonic:Enjoy Analyzing And Integrating The Results From Differential Expression Analysis And Functional Enrichment Analysis

This package provides functionality to combine the existing pieces of the transcriptome data and results, making it easier to generate insightful observations and hypothesis. Its usage is made easy with a Shiny application, combining the benefits of interactivity and reproducibility e.g. by capturing the features and gene sets of interest highlighted during the live session, and creating an HTML report as an artifact where text, code, and output coexist. Using the GeneTonicList as a standardized container for all the required components, it is possible to simplify the generation of multiple visualizations and summaries.

Maintained by Federico Marini. Last updated 2 months ago.

gui geneexpression software transcription transcriptomics visualization differentialexpression pathways reportwriting genesetenrichment annotation go shinyapps bioconductor bioconductor-package data-exploration data-visualization functional-enrichment-analysis gene-expression pathway-analysis reproducible-research rna-seq-analysis rna-seq-data shiny transcriptome user-friendly

10.0 match 77 stars 8.28 score 37 scripts 1 dependents

usepa

tcpl:ToxCast Data Analysis Pipeline

The ToxCast Data Analysis Pipeline ('tcpl') is an R package that manages, curve-fits, plots, and stores ToxCast data to populate its linked MySQL database, 'invitrodb'. The package was developed for the chemical screening data curated by the US EPA's Toxicity Forecaster (ToxCast) program, but 'tcpl' can be used to support diverse chemical screening efforts.

Maintained by Jason Brown. Last updated 3 days ago.

ccte comptox ord

8.8 match 36 stars 9.41 score 90 scripts

bioboot

bio3d:Biological Structure Analysis

Utilities to process, organize and explore protein structure, sequence and dynamics data. Features include the ability to read and write structure, sequence and dynamic trajectory data, perform sequence and structure database searches, data summaries, atom selection, alignment, superposition, rigid core identification, clustering, torsion analysis, distance matrix analysis, structure and sequence conservation analysis, normal mode analysis, principal component analysis of heterogeneous structure data, and correlation network analysis from normal mode and molecular dynamics data. In addition, various utility functions are provided to enable the statistical and graphical power of the R environment to work with biological sequence and structural data. Please refer to the URLs below for more information.

Maintained by Barry Grant. Last updated 5 months ago.

zlib cpp

9.8 match 5 stars 8.49 score 1.4k scripts 10 dependents

bioc

hypeR:An R Package For Geneset Enrichment Workflows

An R Package for Geneset Enrichment Workflows.

Maintained by Anthony Federico. Last updated 5 months ago.

genesetenrichment annotation pathways bioinformatics computational-biology geneset-enrichment-analysis

10.0 match 76 stars 8.22 score 145 scripts

the-hull

datacleanr:Interactive and Reproducible Data Cleaning

Flexible and efficient cleaning of data with interactivity. 'datacleanr' facilitates best practices in data analyses and reproducibility with built-in features and by translating interactive/manual operations to code. The package is designed for interoperability, and so seamlessly fits into reproducible analyses pipelines in 'R'.

Maintained by Alexander Hurley. Last updated 3 years ago.

annotation-tool data-cleaning outlier-detection outlier-removal reproducibility

18.8 match 20 stars 4.38 score 24 scripts

bioc

CNEr:CNE Detection and Visualization

Large-scale identification and advanced visualization of sets of conserved noncoding elements.

Maintained by Ge Tan. Last updated 5 months ago.

generegulation visualization dataimport

8.8 match 3 stars 9.28 score 35 scripts 19 dependents

bioc

PREDA:Position Related Data Analysis

Package for the position related analysis of quantitative functional genomics data.

Maintained by Francesco Ferrari. Last updated 5 months ago.

software copynumbervariation geneexpression genetics

19.1 match 4.30 score 9 scripts

bioc

PhosR:A set of methods and tools for comprehensive analysis of phosphoproteomics data

PhosR is a package for the comprenhensive analysis of phosphoproteomic data. There are two major components to PhosR: processing and downstream analysis. PhosR consists of various processing tools for phosphoproteomics data including filtering, imputation, normalisation, and functional analysis for inferring active kinases and signalling pathways.

Maintained by Taiyun Kim. Last updated 5 months ago.

software researchfield proteomics

17.4 match 4.71 score 51 scripts

bioc

artMS:Analytical R tools for Mass Spectrometry

artMS provides a set of tools for the analysis of proteomics label-free datasets. It takes as input the MaxQuant search result output (evidence.txt file) and performs quality control, relative quantification using MSstats, downstream analysis and integration. artMS also provides a set of functions to re-format and make it compatible with other analytical tools, including, SAINTq, SAINTexpress, Phosfate, and PHOTON. Check [http://artms.org](http://artms.org) for details.

Maintained by David Jimenez-Morales. Last updated 5 months ago.

proteomics differentialexpression biomedicalinformatics systemsbiology massspectrometry annotation qualitycontrol genesetenrichment clustering normalization immunooncology multiplecomparison analysis analytical ap-ms bioconductor bioinformatics mass-spectrometry phosphoproteomics post-translational-modification quantitative-analysis

12.8 match 14 stars 6.41 score 13 scripts

bioc

nullranges:Generation of null ranges via bootstrapping or covariate matching

Modular package for generation of sets of ranges representing the null hypothesis. These can take the form of bootstrap samples of ranges (using the block bootstrap framework of Bickel et al 2010), or sets of control ranges that are matched across one or more covariates. nullranges is designed to be inter-operable with other packages for analysis of genomic overlap enrichment, including the plyranges Bioconductor package.

Maintained by Michael Love. Last updated 5 months ago.

visualization genesetenrichment functionalgenomics epigenetics generegulation genetarget genomeannotation annotation genomewideassociation histonemodification chipseq atacseq dnaseseq rnaseq hiddenmarkovmodel bioconductor bootstrap genomics matching statistics

10.0 match 27 stars 8.16 score 50 scripts 1 dependents

bioc

Rsubread:Mapping, quantification and variant analysis of sequencing data

Alignment, quantification and analysis of RNA sequencing data (including both bulk RNA-seq and scRNA-seq) and DNA sequenicng data (including ATAC-seq, ChIP-seq, WGS, WES etc). Includes functionality for read mapping, read counting, SNP calling, structural variant detection and gene fusion discovery. Can be applied to all major sequencing techologies and to both short and long sequence reads.

Maintained by Wei Shi. Last updated 2 days ago.

sequencing alignment sequencematching rnaseq chipseq singlecell geneexpression generegulation genetics immunooncology snp geneticvariability preprocessing qualitycontrol genomeannotation genefusiondetection indeldetection variantannotation variantdetection multiplesequencealignment zlib

8.8 match 9.24 score 892 scripts 10 dependents

r-forge

genoPlotR:Plot Publication-Grade Gene and Genome Maps

Draws gene or genome maps and comparisons between these, in a publication-grade manner. Starting from simple, common files, it will draw postscript or PDF files that can be sent as such to journals.

Maintained by Lionel Guy. Last updated 4 years ago.

15.1 match 5.33 score 106 scripts

bioc

BUSpaRse:kallisto | bustools R utilities

The kallisto | bustools pipeline is a fast and modular set of tools to convert single cell RNA-seq reads in fastq files into gene count or transcript compatibility counts (TCC) matrices for downstream analysis. Central to this pipeline is the barcode, UMI, and set (BUS) file format. This package serves the following purposes: First, this package allows users to manipulate BUS format files as data frames in R and then convert them into gene count or TCC matrices. Furthermore, since R and Rcpp code is easier to handle than pure C++ code, users are encouraged to tweak the source code of this package to experiment with new uses of BUS format and different ways to convert the BUS file into gene count matrix. Second, this package can conveniently generate files required to generate gene count matrices for spliced and unspliced transcripts for RNA velocity. Here biotypes can be filtered and scaffolds and haplotypes can be removed, and the filtered transcriptome can be extracted and written to disk. Third, this package implements utility functions to get transcripts and associated genes required to convert BUS files to gene count matrices, to write the transcript to gene information in the format required by bustools, and to read output of bustools into R as sparses matrices.

Maintained by Lambda Moses. Last updated 5 months ago.

singlecell rnaseq workflowstep cpp

10.9 match 9 stars 7.35 score 165 scripts

bioc

Qtlizer:Comprehensive QTL annotation of GWAS results

This R package provides access to the Qtlizer web server. Qtlizer annotates lists of common small variants (mainly SNPs) and genes in humans with associated changes in gene expression using the most comprehensive database of published quantitative trait loci (QTLs).

Maintained by Matthias Munz. Last updated 16 days ago.

genomewideassociation snp genetics linkagedisequilibrium eqtl gwas variant-annotation

13.9 match 3 stars 5.73 score 2 scripts

sergeitarasov

ontoFAST:Interactive Annotation of Characters with Biological Ontologies

Tools for annotating characters (character matrices) with anatomical and phenotype ontologies. Includes functions for visualising character annotations and creating simple queries using ontological relationships.

Maintained by Sergei Tarasov. Last updated 3 years ago.

annotations character-matrices characters ontology phylogenetics

26.5 match 2 stars 3.00 score 5 scripts

bioc

packFinder:de novo Annotation of Pack-TYPE Transposable Elements

Algorithm and tools for in silico pack-TYPE transposon discovery. Filters a given genome for properties unique to DNA transposons and provides tools for the investigation of returned matches. Sequences are input in DNAString format, and ranges are returned as a dataframe (in the format returned by as.dataframe(GRanges)).

Maintained by Jack Gisby. Last updated 5 months ago.

genetics sequencematching annotation bioinformatics text-mining

16.4 match 7 stars 4.85 score 6 scripts

cox-labs

PerseusR:Perseus R Interop

Enables the interoperability between the Perseus platform for omics data analysis (Tyanova et al. 2016) <doi:10.1038/nmeth.3901> and R. It provides the foundation for developing and running Perseus plugins implemented in R by providing all required input and output handling, including data and parameter parsing as described in Rudolph and Cox 2018 <doi:10.1101/447268>.

Maintained by Jan Rudolph. Last updated 3 years ago.

bioinformatics interop maxquant perseus proteomics

13.5 match 13 stars 5.88 score 58 scripts

clewerenz

ilabelled:Simple Handling of Labelled Data

Simple handling of survey data. Smart handling of meta-information like e.g. variable-labels value-labels and scale-levels. Easy access and validation of meta-information. Useage of value labels and values respectively for subsetting and recoding data.

Maintained by Christof Lewerenz. Last updated 2 months ago.

13.0 match 2 stars 6.02 score 13 scripts

bioc

recoup:An R package for the creation of complex genomic profile plots

recoup calculates and plots signal profiles created from short sequence reads derived from Next Generation Sequencing technologies. The profiles provided are either sumarized curve profiles or heatmap profiles. Currently, recoup supports genomic profile plots for reads derived from ChIP-Seq and RNA-Seq experiments. The package uses ggplot2 and ComplexHeatmap graphics facilities for curve and heatmap coverage profiles respectively.

Maintained by Panagiotis Moulos. Last updated 5 months ago.

immunooncology software geneexpression preprocessing qualitycontrol rnaseq chipseq sequencing coverage atacseq chiponchip alignment dataimport

15.5 match 1 stars 5.02 score 2 scripts

bioc

rrvgo:Reduce + Visualize GO

Reduce and visualize lists of Gene Ontology terms by identifying redudance based on semantic similarity.

Maintained by Sergi Sayols. Last updated 5 months ago.

annotation clustering go network pathways software

10.0 match 24 stars 7.74 score 190 scripts

kasperwelbers

corpustools:Managing, Querying and Analyzing Tokenized Text

Provides text analysis in R, focusing on the use of a tokenized text format. In this format, the positions of tokens are maintained, and each token can be annotated (e.g., part-of-speech tags, dependency relations). Prominent features include advanced Lucene-like querying for specific tokens or contexts (e.g., documents, sentences), similarity statistics for words and documents, exporting to DTM for compatibility with many text analysis packages, and the possibility to reconstruct original text from tokens to facilitate interpretation.

Maintained by Kasper Welbers. Last updated 6 months ago.

cpp

10.3 match 31 stars 7.50 score 174 scripts 1 dependents

bioc

crisprViz:Visualization Functions for CRISPR gRNAs

Provides functionalities to visualize and contextualize CRISPR guide RNAs (gRNAs) on genomic tracks across nucleases and applications. Works in conjunction with the crisprBase and crisprDesign Bioconductor packages. Plots are produced using the Gviz framework.

Maintained by Jean-Philippe Fortin. Last updated 5 months ago.

crispr functionalgenomics genetarget bioconductor bioconductor-package crispr-analysis crispr-design grna grna-sequence grna-sequences sgrna sgrna-design visualization

12.3 match 7 stars 6.23 score 6 scripts 2 dependents

bioc

mgsa:Model-based gene set analysis

Model-based Gene Set Analysis (MGSA) is a Bayesian modeling approach for gene set enrichment. The package mgsa implements MGSA and tools to use MGSA together with the Gene Ontology.

Maintained by Sebastian Bauer. Last updated 5 months ago.

pathways go genesetenrichment openmp

12.6 match 5 stars 6.08 score 12 scripts

matrix-profile-foundation

tsmp:Time Series with Matrix Profile

A toolkit implementing the Matrix Profile concept that was created by CS-UCR <http://www.cs.ucr.edu/~eamonn/MatrixProfile.html>.

Maintained by Francisco Bischoff. Last updated 3 years ago.

algorithm matrix-profile motif-search time-series cpp

10.4 match 72 stars 7.29 score 179 scripts 1 dependents

polmine

polmineR:Verbs and Nouns for Corpus Analysis

Package for corpus analysis using the Corpus Workbench ('CWB', <https://cwb.sourceforge.io>) as an efficient back end for indexing and querying large corpora. The package offers functionality to flexibly create subcorpora and to carry out basic statistical operations (count, co-occurrences etc.). The original full text of documents can be reconstructed and inspected at any time. Beyond that, the package is intended to serve as an interface to packages implementing advanced statistical procedures. Respective data structures (document-term matrices, term-co-occurrence matrices etc.) can be created based on the indexed corpora.

Maintained by Andreas Blaette. Last updated 1 years ago.

9.5 match 49 stars 7.96 score 311 scripts

bioc

meshr:Tools for conducting enrichment analysis of MeSH

A set of annotation maps describing the entire MeSH assembled using data from MeSH.

Maintained by Koki Tsuyuzaki. Last updated 5 months ago.

annotationdata functionalannotation bioinformatics statistics annotation multiplecomparisons meshdb

16.6 match 4.56 score 9 scripts 1 dependents

bioc

pathview:a tool set for pathway based data integration and visualization

Pathview is a tool set for pathway based data integration and visualization. It maps and renders a wide variety of biological data on relevant pathway graphs. All users need is to supply their data and specify the target pathway. Pathview automatically downloads the pathway graph data, parses the data file, maps user data to the pathway, and render pathway graph with the mapped data. In addition, Pathview also seamlessly integrates with pathway and gene set (enrichment) analysis tools for large-scale and fully automated analysis.

Maintained by Weijun Luo. Last updated 5 months ago.

pathways graphandnetwork visualization genesetenrichment differentialexpression geneexpression microarray rnaseq genetics metabolomics proteomics systemsbiology sequencing

6.7 match 40 stars 11.24 score 1.6k scripts 10 dependents

bioc

maser:Mapping Alternative Splicing Events to pRoteins

This package provides functionalities for downstream analysis, annotation and visualizaton of alternative splicing events generated by rMATS.

Maintained by Diogo F.T. Veiga. Last updated 5 months ago.

alternativesplicing transcriptomics visualization

11.1 match 17 stars 6.74 score 18 scripts

bioc

profileplyr:Visualization and annotation of read signal over genomic ranges with profileplyr

Quick and straightforward visualization of read signal over genomic intervals is key for generating hypotheses from sequencing data sets (e.g. ChIP-seq, ATAC-seq, bisulfite/methyl-seq). Many tools both inside and outside of R and Bioconductor are available to explore these types of data, and they typically start with a bigWig or BAM file and end with some representation of the signal (e.g. heatmap). profileplyr leverages many Bioconductor tools to allow for both flexibility and additional functionality in workflows that end with visualization of the read signal.

Maintained by Tom Carroll. Last updated 5 months ago.

chipseq dataimport sequencing chiponchip coverage

18.6 match 4.03 score 54 scripts

bioc

crisprShiny:Exploring curated CRISPR gRNAs via Shiny

Provides means to interactively visualize guide RNAs (gRNAs) in GuideSet objects via Shiny application. This GUI can be self-contained or as a module within a larger Shiny app. The content of the app reflects the annotations present in the passed GuideSet object, and includes intuitive tools to examine, filter, and export gRNAs, thereby making gRNA design more user-friendly.

Maintained by Jean-Philippe Fortin. Last updated 5 months ago.

crispr functionalgenomics genetarget gui crispr-analysis crispr-design shiny

16.7 match 2 stars 4.48 score 8 scripts

jbkunst

highcharter:A Wrapper for the 'Highcharts' Library

A wrapper for the 'Highcharts' library including shortcut functions to plot R objects. 'Highcharts' <https://www.highcharts.com/> is a charting library offering numerous chart types with a simple configuration syntax.

Maintained by Joshua Kunst. Last updated 1 years ago.

highcharts htmlwidgets shiny shiny-r visualization wrapper

5.4 match 725 stars 13.93 score 4.9k scripts 18 dependents

bioc

isomiRs:Analyze isomiRs and miRNAs from small RNA-seq

Characterization of miRNAs and isomiRs, clustering and differential expression.

Maintained by Lorena Pantano. Last updated 5 months ago.

mirna rnaseq differentialexpression clustering immunooncology analyze-isomirs bioconductor isomirs

10.6 match 8 stars 7.09 score 43 scripts

bioc

myvariant:Accesses MyVariant.info variant query and annotation services

MyVariant.info is a comprehensive aggregation of variant annotation resources. myvariant is a wrapper for querying MyVariant.info services

Maintained by Adam Mark, Chunlei Wu. Last updated 5 months ago.

variantannotation annotation genomicvariation

15.1 match 4.92 score 28 scripts

eltebioinformatics

mulea:Enrichment Analysis Using Multiple Ontologies and False Discovery Rate

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

Maintained by Tamas Stirling. Last updated 3 months ago.

annotation differentialexpression geneexpression genesetenrichment go graphandnetwork multiplecomparison pathways reactome software transcription visualization enrichment enrichment-analysis functional-enrichment-analysis gene-set-enrichment ontologies transcriptomics cpp

10.0 match 28 stars 7.36 score 34 scripts

digi-vub

recogito:Interactive Annotation of Text and Images

Annotate text with entities and the relations between them. Annotate areas of interest in images with your labels. Providing 'htmlwidgets' bindings to the 'recogito' <https://github.com/recogito/recogito-js> and 'annotorious' <https://github.com/recogito/annotorious> libraries.

Maintained by Jan Wijffels. Last updated 3 years ago.

17.3 match 21 stars 4.25 score 17 scripts

bioc

GenomicPlot:Plot profiles of next generation sequencing data in genomic features

Visualization of next generation sequencing (NGS) data is essential for interpreting high-throughput genomics experiment results. 'GenomicPlot' facilitates plotting of NGS data in various formats (bam, bed, wig and bigwig); both coverage and enrichment over input can be computed and displayed with respect to genomic features (such as UTR, CDS, enhancer), and user defined genomic loci or regions. Statistical tests on signal intensity within user defined regions of interest can be performed and represented as boxplots or bar graphs. Parallel processing is used to speed up computation on multicore platforms. In addition to genomic plots which is suitable for displaying of coverage of genomic DNA (such as ChIPseq data), metagenomic (without introns) plots can also be made for RNAseq or CLIPseq data as well.

Maintained by Shuye Pu. Last updated 2 months ago.

alternativesplicing chipseq coverage geneexpression rnaseq sequencing software transcription visualization annotation

13.1 match 3 stars 5.62 score 4 scripts

bioc

NormalyzerDE:Evaluation of normalization methods and calculation of differential expression analysis statistics

NormalyzerDE provides screening of normalization methods for LC-MS based expression data. It calculates a range of normalized matrices using both existing approaches and a novel time-segmented approach, calculates performance measures and generates an evaluation report. Furthermore, it provides an easy utility for Limma- or ANOVA- based differential expression analysis.

Maintained by Jakob Willforss. Last updated 5 months ago.

normalization multiplecomparison visualization bayesian proteomics metabolomics differentialexpression bioconductor bioinformatics limma

10.0 match 22 stars 7.30 score 38 scripts 1 dependents