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pbreheny
plmmr:Penalized Linear Mixed Models for Correlated Data
Fits penalized linear mixed models that correct for unobserved confounding factors. 'plmmr' infers and corrects for the presence of unobserved confounding effects such as population stratification and environmental heterogeneity. It then fits a linear model via penalized maximum likelihood. Originally designed for the multivariate analysis of single nucleotide polymorphisms (SNPs) measured in a genome-wide association study (GWAS), 'plmmr' eliminates the need for subpopulation-specific analyses and post-analysis p-value adjustments. Functions for the appropriate processing of 'PLINK' files are also supplied. For examples, see the package homepage. <https://pbreheny.github.io/plmmr/>.
Maintained by Patrick J. Breheny. Last updated 12 days ago.
5 stars 6.41 score 10 scripts
jaehyunparkbiostat
fusedMGM:Implementation of Fused MGM to Infer 2-Class Networks
Implementation of fused Markov graphical model (FMGM; Park and Won, 2022). The functions include building mixed graphical model (MGM) objects from data, inference of networks using FMGM, stable edge-specific penalty selection (StEPS) for the determination of penalization parameters, and the visualization. For details, please refer to Park and Won (2022) <doi:10.48550/arXiv.2208.14959>.
Maintained by Jaehyun Park. Last updated 6 months ago.
1.00 score