R-universe search: identifiability

ropensci

CoordinateCleaner:Automated Cleaning of Occurrence Records from Biological Collections

Automated flagging of common spatial and temporal errors in biological and paleontological collection data, for the use in conservation, ecology and paleontology. Includes automated tests to easily flag (and exclude) records assigned to country or province centroid, the open ocean, the headquarters of the Global Biodiversity Information Facility, urban areas or the location of biodiversity institutions (museums, zoos, botanical gardens, universities). Furthermore identifies per species outlier coordinates, zero coordinates, identical latitude/longitude and invalid coordinates. Also implements an algorithm to identify data sets with a significant proportion of rounded coordinates. Especially suited for large data sets. The reference for the methodology is: Zizka et al. (2019) <doi:10.1111/2041-210X.13152>.

Maintained by Alexander Zizka. Last updated 1 years ago.

40.9 match 82 stars 10.93 score 306 scripts 3 dependents

patzaw

BED:Biological Entity Dictionary (BED)

An interface for the 'Neo4j' database providing mapping between different identifiers of biological entities. This Biological Entity Dictionary (BED) has been developed to address three main challenges. The first one is related to the completeness of identifier mappings. Indeed, direct mapping information provided by the different systems are not always complete and can be enriched by mappings provided by other resources. More interestingly, direct mappings not identified by any of these resources can be indirectly inferred by using mappings to a third reference. For example, many human Ensembl gene ID are not directly mapped to any Entrez gene ID but such mappings can be inferred using respective mappings to HGNC ID. The second challenge is related to the mapping of deprecated identifiers. Indeed, entity identifiers can change from one resource release to another. The identifier history is provided by some resources, such as Ensembl or the NCBI, but it is generally not used by mapping tools. The third challenge is related to the automation of the mapping process according to the relationships between the biological entities of interest. Indeed, mapping between gene and protein ID scopes should not be done the same way than between two scopes regarding gene ID. Also, converting identifiers from different organisms should be possible using gene orthologs information. The method has been published by Godard and van Eyll (2018) <doi:10.12688/f1000research.13925.3>.

Maintained by Patrice Godard. Last updated 3 months ago.

59.6 match 8 stars 6.85 score 25 scripts

bioc

OmnipathR:OmniPath web service client and more

A client for the OmniPath web service (https://www.omnipathdb.org) and many other resources. It also includes functions to transform and pretty print some of the downloaded data, functions to access a number of other resources such as BioPlex, ConsensusPathDB, EVEX, Gene Ontology, Guide to Pharmacology (IUPHAR/BPS), Harmonizome, HTRIdb, Human Phenotype Ontology, InWeb InBioMap, KEGG Pathway, Pathway Commons, Ramilowski et al. 2015, RegNetwork, ReMap, TF census, TRRUST and Vinayagam et al. 2011. Furthermore, OmnipathR features a close integration with the NicheNet method for ligand activity prediction from transcriptomics data, and its R implementation `nichenetr` (available only on github).

Maintained by Denes Turei. Last updated 20 days ago.

graphandnetwork network pathways software thirdpartyclient dataimport datarepresentation genesignaling generegulation systemsbiology transcriptomics singlecell annotation kegg complexes enzyme-ptm networks networks-biology omnipath proteins quarto

31.1 match 126 stars 9.90 score 226 scripts 2 dependents

bioc

gDRutils:A package with helper functions for processing drug response data

This package contains utility functions used throughout the gDR platform to fit data, manipulate data, and convert and validate data structures. This package also has the necessary default constants for gDR platform. Many of the functions are utilized by the gDRcore package.

Maintained by Arkadiusz Gladki. Last updated 6 days ago.

software infrastructure

40.0 match 2 stars 7.40 score 3 scripts 3 dependents

ropensci

lingtypology:Linguistic Typology and Mapping

Provides R with the Glottolog database <https://glottolog.org/> and some more abilities for purposes of linguistic mapping. The Glottolog database contains the catalogue of languages of the world. This package helps researchers to make a linguistic maps, using philosophy of the Cross-Linguistic Linked Data project <https://clld.org/>, which allows for while at the same time facilitating uniform access to the data across publications. A tutorial for this package is available on GitHub pages <https://docs.ropensci.org/lingtypology/> and package vignette. Maps created by this package can be used both for the investigation and linguistic teaching. In addition, package provides an ability to download data from typological databases such as WALS, AUTOTYP and some others and to create your own database website.

Maintained by George Moroz. Last updated 5 months ago.

abvd afbo atlas autotype bivaltyp clld glottolog-database linguistic-maps linguistics phoible sails typology wals

30.7 match 51 stars 9.58 score 694 scripts

bioc

BridgeDbR:Code for using BridgeDb identifier mapping framework from within R

Use BridgeDb functions and load identifier mapping databases in R. It uses GitHub, Zenodo, and Figshare if you use this package to download identifier mappings files.

Maintained by Egon Willighagen. Last updated 4 months ago.

software annotation metabolomics cheminformatics bioconductor-package bridgedb genes identifiers life-sciences metabolites proteins openjdk

36.5 match 4 stars 6.97 score 43 scripts

ropensci

webchem:Chemical Information from the Web

Chemical information from around the web. This package interacts with a suite of web services for chemical information. Sources include: Alan Wood's Compendium of Pesticide Common Names, Chemical Identifier Resolver, ChEBI, Chemical Translation Service, ChemSpider, ETOX, Flavornet, NIST Chemistry WebBook, OPSIN, PubChem, SRS, Wikidata.

Maintained by Tamás Stirling. Last updated 3 months ago.

cas-number chemical-information chemspider identifier ropensci webscraping

23.2 match 165 stars 10.31 score 173 scripts 10 dependents

ropensci

taxize:Taxonomic Information from Around the Web

Interacts with a suite of web application programming interfaces (API) for taxonomic tasks, such as getting database specific taxonomic identifiers, verifying species names, getting taxonomic hierarchies, fetching downstream and upstream taxonomic names, getting taxonomic synonyms, converting scientific to common names and vice versa, and more. Some of the services supported include 'NCBI E-utilities' (<https://www.ncbi.nlm.nih.gov/books/NBK25501/>), 'Encyclopedia of Life' (<https://eol.org/docs/what-is-eol/data-services>), 'Global Biodiversity Information Facility' (<https://techdocs.gbif.org/en/openapi/>), and many more. Links to the API documentation for other supported services are available in the documentation for their respective functions in this package.

Maintained by Zachary Foster. Last updated 13 days ago.

taxonomy biology nomenclature json api web api-client identifiers species names api-wrapper biodiversity darwincore data taxize

15.6 match 274 stars 13.63 score 1.6k scripts 23 dependents

edjnet

tidywikidatar:Explore 'Wikidata' Through Tidy Data Frames

Query 'Wikidata' API <https://www.wikidata.org/wiki/Wikidata:Main_Page> with ease, get tidy data frames in response, and cache data in a local database.

Maintained by Giorgio Comai. Last updated 8 months ago.

wikidata

25.1 match 26 stars 7.76 score 46 scripts 2 dependents

jl5000

tidyged:Handle GEDCOM Files Using Tidyverse Principles

Create and summarise family tree GEDCOM files using tidy dataframes.

Maintained by Jamie Lendrum. Last updated 3 years ago.

31.4 match 8 stars 5.96 score 23 scripts 3 dependents

dataoneorg

dataone:R Interface to the DataONE REST API

Provides read and write access to data and metadata from the DataONE network <https://www.dataone.org> of data repositories. Each DataONE repository implements a consistent repository application programming interface. Users call methods in R to access these remote repository functions, such as methods to query the metadata catalog, get access to metadata for particular data packages, and read the data objects from the data repository. Users can also insert and update data objects on repositories that support these methods.

Maintained by Matthew B. Jones. Last updated 3 years ago.

18.7 match 36 stars 9.93 score 472 scripts 3 dependents

bioc

biomaRt:Interface to BioMart databases (i.e. Ensembl)

In recent years a wealth of biological data has become available in public data repositories. Easy access to these valuable data resources and firm integration with data analysis is needed for comprehensive bioinformatics data analysis. biomaRt provides an interface to a growing collection of databases implementing the BioMart software suite (<http://www.biomart.org>). The package enables retrieval of large amounts of data in a uniform way without the need to know the underlying database schemas or write complex SQL queries. The most prominent examples of BioMart databases are maintain by Ensembl, which provides biomaRt users direct access to a diverse set of data and enables a wide range of powerful online queries from gene annotation to database mining.

Maintained by Mike Smith. Last updated 3 days ago.

annotation bioconductor biomart ensembl

11.4 match 38 stars 15.99 score 13k scripts 230 dependents

bioc

goProfiles:goProfiles: an R package for the statistical analysis of functional profiles

The package implements methods to compare lists of genes based on comparing the corresponding 'functional profiles'.

Maintained by Alex Sanchez. Last updated 5 months ago.

annotation go geneexpression genesetenrichment graphandnetwork microarray multiplecomparison pathways software

31.0 match 5.48 score 6 scripts 1 dependents

bioc

ELMER:Inferring Regulatory Element Landscapes and Transcription Factor Networks Using Cancer Methylomes

ELMER is designed to use DNA methylation and gene expression from a large number of samples to infere regulatory element landscape and transcription factor network in primary tissue.

Maintained by Tiago Chedraoui Silva. Last updated 5 months ago.

dnamethylation geneexpression motifannotation software generegulation transcription network

21.0 match 7.42 score 176 scripts

olink-proteomics

OlinkAnalyze:Facilitate Analysis of Proteomic Data from Olink

A collection of functions to facilitate analysis of proteomic data from Olink, primarily NPX data that has been exported from Olink Software. The functions also work on QUANT data from Olink by log- transforming the QUANT data. The functions are focused on reading data, facilitating data wrangling and quality control analysis, performing statistical analysis and generating figures to visualize the results of the statistical analysis. The goal of this package is to help users extract biological insights from proteomic data run on the Olink platform.

Maintained by Kathleen Nevola. Last updated 21 days ago.

olink proteomics proteomics-data-analysis

16.0 match 104 stars 9.72 score 61 scripts

bioc

DTA:Dynamic Transcriptome Analysis

Dynamic Transcriptome Analysis (DTA) can monitor the cellular response to perturbations with higher sensitivity and temporal resolution than standard transcriptomics. The package implements the underlying kinetic modeling approach capable of the precise determination of synthesis- and decay rates from individual microarray or RNAseq measurements.

Maintained by Bjoern Schwalb. Last updated 5 months ago.

microarray differentialexpression geneexpression transcription

31.6 match 4.78 score 5 scripts 1 dependents

reside-ic

ids:Generate Random Identifiers

Generate random or human readable and pronounceable identifiers.

Maintained by Rich FitzJohn. Last updated 3 years ago.

11.3 match 94 stars 13.27 score 175 scripts 165 dependents

ramiromagno

quincunx:REST API Client for the 'PGS' Catalog

Programmatic access to the 'PGS' Catalog. This package provides easy access to 'PGS' Catalog data by accessing the REST API <https://www.pgscatalog.org/rest/>.

Maintained by Ramiro Magno. Last updated 3 years ago.

ebi gwas polygenic-risk-scores polygenic-scores

47.5 match 14 stars 3.10 score 18 scripts

kbroman

qtl:Tools for Analyzing QTL Experiments

Analysis of experimental crosses to identify genes (called quantitative trait loci, QTLs) contributing to variation in quantitative traits. Broman et al. (2003) <doi:10.1093/bioinformatics/btg112>.

Maintained by Karl W Broman. Last updated 7 months ago.

openblas

11.4 match 80 stars 12.79 score 2.4k scripts 29 dependents

microsoft

wpa:Tools for Analysing and Visualising Viva Insights Data

Opinionated functions that enable easier and faster analysis of Viva Insights data. There are three main types of functions in 'wpa': (i) Standard functions create a 'ggplot' visual or a summary table based on a specific Viva Insights metric; (2) Report Generation functions generate HTML reports on a specific analysis area, e.g. Collaboration; (3) Other miscellaneous functions cover more specific applications (e.g. Subject Line text mining) of Viva Insights data. This package adheres to 'tidyverse' principles and works well with the pipe syntax. 'wpa' is built with the beginner-to-intermediate R users in mind, and is optimised for simplicity.

Maintained by Martin Chan. Last updated 4 months ago.

workplace-analytics

21.5 match 30 stars 6.69 score 39 scripts 1 dependents

lucaweihs

SEMID:Identifiability of Linear Structural Equation Models

Provides routines to check identifiability or non-identifiability of linear structural equation models as described in Drton, Foygel, and Sullivant (2011) <doi:10.1214/10-AOS859>, Foygel, Draisma, and Drton (2012) <doi:10.1214/12-AOS1012>, and other works. The routines are based on the graphical representation of structural equation models.

Maintained by Nils Sturma. Last updated 2 years ago.

35.1 match 4 stars 4.06 score 29 scripts

jiang-junyao

CACIMAR:cross-species analysis of cell identities, markers and regulations

A toolkit to perform cross-species analysis based on scRNA-seq data. CACIMAR contains 5 main features. (1) identify Markers in each cluster. (2) Cell type annotaion (3) identify conserved markers. (4) identify conserved cell types. (5) identify conserved modules of regulatory networks.

Maintained by Junyao Jiang. Last updated 3 months ago.

cross-species-analysis scrna-seq

25.5 match 12 stars 5.26 score 6 scripts

bioc

xcms:LC-MS and GC-MS Data Analysis

Framework for processing and visualization of chromatographically separated and single-spectra mass spectral data. Imports from AIA/ANDI NetCDF, mzXML, mzData and mzML files. Preprocesses data for high-throughput, untargeted analyte profiling.

Maintained by Steffen Neumann. Last updated 4 days ago.

immunooncology massspectrometry metabolomics bioconductor feature-detection mass-spectrometry peak-detection cpp

9.1 match 196 stars 14.31 score 984 scripts 11 dependents

darwin-eu

omopgenerics:Methods and Classes for the OMOP Common Data Model

Provides definitions of core classes and methods used by analytic pipelines that query the OMOP (Observational Medical Outcomes Partnership) common data model.

Maintained by Martí Català. Last updated 11 days ago.

12.7 match 9.97 score 193 scripts 16 dependents

andrisignorell

DescTools:Tools for Descriptive Statistics

A collection of miscellaneous basic statistic functions and convenience wrappers for efficiently describing data. The author's intention was to create a toolbox, which facilitates the (notoriously time consuming) first descriptive tasks in data analysis, consisting of calculating descriptive statistics, drawing graphical summaries and reporting the results. The package contains furthermore functions to produce documents using MS Word (or PowerPoint) and functions to import data from Excel. Many of the included functions can be found scattered in other packages and other sources written partly by Titans of R. The reason for collecting them here, was primarily to have them consolidated in ONE instead of dozens of packages (which themselves might depend on other packages which are not needed at all), and to provide a common and consistent interface as far as function and arguments naming, NA handling, recycling rules etc. are concerned. Google style guides were used as naming rules (in absence of convincing alternatives). The 'BigCamelCase' style was consequently applied to functions borrowed from contributed R packages as well.

Maintained by Andri Signorell. Last updated 2 days ago.

fortran cpp

7.5 match 87 stars 16.70 score 7.7k scripts 99 dependents

bioc

MsQuality:MsQuality - Quality metric calculation from Spectra and MsExperiment objects

The MsQuality provides functionality to calculate quality metrics for mass spectrometry-derived, spectral data at the per-sample level. MsQuality relies on the mzQC framework of quality metrics defined by the Human Proteom Organization-Proteomics Standards Initiative (HUPO-PSI). These metrics quantify the quality of spectral raw files using a controlled vocabulary. The package is especially addressed towards users that acquire mass spectrometry data on a large scale (e.g. data sets from clinical settings consisting of several thousands of samples). The MsQuality package allows to calculate low-level quality metrics that require minimum information on mass spectrometry data: retention time, m/z values, and associated intensities. MsQuality relies on the Spectra package, or alternatively the MsExperiment package, and its infrastructure to store spectral data.

Maintained by Thomas Naake. Last updated 2 months ago.

metabolomics proteomics massspectrometry qualitycontrol mass-spectrometry qc

22.5 match 7 stars 5.45 score 2 scripts

bioc

singleCellTK:Comprehensive and Interactive Analysis of Single Cell RNA-Seq Data

The Single Cell Toolkit (SCTK) in the singleCellTK package provides an interface to popular tools for importing, quality control, analysis, and visualization of single cell RNA-seq data. SCTK allows users to seamlessly integrate tools from various packages at different stages of the analysis workflow. A general "a la carte" workflow gives users the ability access to multiple methods for data importing, calculation of general QC metrics, doublet detection, ambient RNA estimation and removal, filtering, normalization, batch correction or integration, dimensionality reduction, 2-D embedding, clustering, marker detection, differential expression, cell type labeling, pathway analysis, and data exporting. Curated workflows can be used to run Seurat and Celda. Streamlined quality control can be performed on the command line using the SCTK-QC pipeline. Users can analyze their data using commands in the R console or by using an interactive Shiny Graphical User Interface (GUI). Specific analyses or entire workflows can be summarized and shared with comprehensive HTML reports generated by Rmarkdown. Additional documentation and vignettes can be found at camplab.net/sctk.

Maintained by Joshua David Campbell. Last updated 25 days ago.

singlecell geneexpression differentialexpression alignment clustering immunooncology batcheffect normalization qualitycontrol dataimport gui

11.9 match 181 stars 10.16 score 252 scripts

bioc

decontam:Identify Contaminants in Marker-gene and Metagenomics Sequencing Data

Simple statistical identification of contaminating sequence features in marker-gene or metagenomics data. Works on any kind of feature derived from environmental sequencing data (e.g. ASVs, OTUs, taxonomic groups, MAGs,...). Requires DNA quantitation data or sequenced negative control samples.

Maintained by Benjamin Callahan. Last updated 5 months ago.

immunooncology microbiome sequencing classification metagenomics amplicon bioinformatics contamination metabarcoding

10.6 match 153 stars 11.42 score 524 scripts 6 dependents

microsoft

vivainsights:Analyze and Visualize Data from 'Microsoft Viva Insights'

Provides a versatile range of functions, including exploratory data analysis, time-series analysis, organizational network analysis, and data validation, whilst at the same time implements a set of best practices in analyzing and visualizing data specific to 'Microsoft Viva Insights'.

Maintained by Martin Chan. Last updated 25 days ago.

19.7 match 11 stars 6.12 score 68 scripts

openbiox

UCSCXenaShiny:Interactive Analysis of UCSC Xena Data

Provides functions and a Shiny application for downloading, analyzing and visualizing datasets from UCSC Xena (<http://xena.ucsc.edu/>), which is a collection of UCSC-hosted public databases such as TCGA, ICGC, TARGET, GTEx, CCLE, and others.

Maintained by Shixiang Wang. Last updated 4 months ago.

cancer-dataset shiny-apps ucsc-xena

14.0 match 96 stars 8.54 score 35 scripts

bioc

rhdf5:R Interface to HDF5

This package provides an interface between HDF5 and R. HDF5's main features are the ability to store and access very large and/or complex datasets and a wide variety of metadata on mass storage (disk) through a completely portable file format. The rhdf5 package is thus suited for the exchange of large and/or complex datasets between R and other software package, and for letting R applications work on datasets that are larger than the available RAM.

Maintained by Mike Smith. Last updated 2 months ago.

infrastructure dataimport hdf5 rhdf5 openssl curl zlib cpp

7.2 match 62 stars 15.93 score 4.2k scripts 232 dependents

r-forge

FME:A Flexible Modelling Environment for Inverse Modelling, Sensitivity, Identifiability and Monte Carlo Analysis

Provides functions to help in fitting models to data, to perform Monte Carlo, sensitivity and identifiability analysis. It is intended to work with models be written as a set of differential equations that are solved either by an integration routine from package 'deSolve', or a steady-state solver from package 'rootSolve'. However, the methods can also be used with other types of functions.

Maintained by Karline Soetaert. Last updated 2 years ago.

fortran

13.3 match 8.62 score 382 scripts 9 dependents

sciviews

pastecs:Package for Analysis of Space-Time Ecological Series

Regularisation, decomposition and analysis of space-time series. The pastecs R package is a PNEC-Art4 and IFREMER (Benoit Beliaeff <Benoit.Beliaeff@ifremer.fr>) initiative to bring PASSTEC 2000 functionalities to R.

Maintained by Philippe Grosjean. Last updated 1 years ago.

ecology time-series

11.0 match 4 stars 10.34 score 2.1k scripts 13 dependents

charlie86

spotifyr:R Wrapper for the 'Spotify' Web API

An R wrapper for pulling data from the 'Spotify' Web API <https://developer.spotify.com/documentation/web-api/> in bulk, or post items on a 'Spotify' user's playlist.

Maintained by Daniel Antal. Last updated 5 months ago.

music-information-retrieval spotify

13.3 match 374 stars 8.54 score 936 scripts

deepayan

lattice:Trellis Graphics for R

A powerful and elegant high-level data visualization system inspired by Trellis graphics, with an emphasis on multivariate data. Lattice is sufficient for typical graphics needs, and is also flexible enough to handle most nonstandard requirements. See ?Lattice for an introduction.

Maintained by Deepayan Sarkar. Last updated 11 months ago.

6.3 match 68 stars 17.33 score 27k scripts 13k dependents

brunobrr

bdc:Biodiversity Data Cleaning

It brings together several aspects of biodiversity data-cleaning in one place. 'bdc' is organized in thematic modules related to different biodiversity dimensions, including 1) Merge datasets: standardization and integration of different datasets; 2) Pre-filter: flagging and removal of invalid or non-interpretable information, followed by data amendments; 3) Taxonomy: cleaning, parsing, and harmonization of scientific names from several taxonomic groups against taxonomic databases locally stored through the application of exact and partial matching algorithms; 4) Space: flagging of erroneous, suspect, and low-precision geographic coordinates; and 5) Time: flagging and, whenever possible, correction of inconsistent collection date. In addition, it contains features to visualize, document, and report data quality – which is essential for making data quality assessment transparent and reproducible. The reference for the methodology is Bruno et al. (2022) <doi:10.1111/2041-210X.13868>.

Maintained by Bruno Ribeiro. Last updated 3 months ago.

bdc biodiversity-data workflow

16.1 match 24 stars 6.66 score 53 scripts

pmartr

pmartR:Panomics Marketplace - Quality Control and Statistical Analysis for Panomics Data

Provides functionality for quality control processing and statistical analysis of mass spectrometry (MS) omics data, in particular proteomic (either at the peptide or the protein level), lipidomic, and metabolomic data, as well as RNA-seq based count data and nuclear magnetic resonance (NMR) data. This includes data transformation, specification of groups that are to be compared against each other, filtering of features and/or samples, data normalization, data summarization (correlation, PCA), and statistical comparisons between defined groups. Implements methods described in: Webb-Robertson et al. (2014) <doi:10.1074/mcp.M113.030932>. Webb-Robertson et al. (2011) <doi:10.1002/pmic.201100078>. Matzke et al. (2011) <doi:10.1093/bioinformatics/btr479>. Matzke et al. (2013) <doi:10.1002/pmic.201200269>. Polpitiya et al. (2008) <doi:10.1093/bioinformatics/btn217>. Webb-Robertson et al. (2010) <doi:10.1021/pr1005247>.

Maintained by Lisa Bramer. Last updated 4 days ago.

data-summarization lipids mass-spectrometry metabolites metabolomics-data peptides proteins rna-seq-analysis openblas cpp

13.9 match 40 stars 7.69 score 144 scripts

nutriverse

nipnTK:National Information Platforms for Nutrition Anthropometric Data Toolkit

An implementation of the National Information Platforms for Nutrition or NiPN's analytic methods for assessing quality of anthropometric datasets that include measurements of weight, height or length, middle upper arm circumference, sex and age. The focus is on anthropometric status but many of the presented methods could be applied to other variables.

Maintained by Ernest Guevarra. Last updated 5 months ago.

anthropometry data-quality nipn nutrition

17.5 match 5 stars 5.92 score 28 scripts 1 dependents

sjmack

HLAtools:Toolkit for HLA Immunogenomics

A toolkit for the analysis and management of data for genes in the so-called "Human Leukocyte Antigen" (HLA) region. Functions extract reference data from the Anthony Nolan HLA Informatics Group/ImmunoGeneTics HLA 'GitHub' repository (ANHIG/IMGTHLA) <https://github.com/ANHIG/IMGTHLA>, validate Genotype List (GL) Strings, convert between UNIFORMAT and GL String Code (GLSC) formats, translate HLA alleles and GLSCs across ImmunoPolymorphism Database (IPD) IMGT/HLA Database release versions, identify differences between pairs of alleles at a locus, generate customized, multi-position sequence alignments, trim and convert allele-names across nomenclature epochs, and extend existing data-analysis methods.

Maintained by Steven Mack. Last updated 14 days ago.

16.6 match 4 stars 6.21 score 7 scripts 1 dependents

spatstat

spatstat.geom:Geometrical Functionality of the 'spatstat' Family

Defines spatial data types and supports geometrical operations on them. Data types include point patterns, windows (domains), pixel images, line segment patterns, tessellations and hyperframes. Capabilities include creation and manipulation of data (using command line or graphical interaction), plotting, geometrical operations (rotation, shift, rescale, affine transformation), convex hull, discretisation and pixellation, Dirichlet tessellation, Delaunay triangulation, pairwise distances, nearest-neighbour distances, distance transform, morphological operations (erosion, dilation, closing, opening), quadrat counting, geometrical measurement, geometrical covariance, colour maps, calculus on spatial domains, Gaussian blur, level sets of images, transects of images, intersections between objects, minimum distance matching. (Excludes spatial data on a network, which are supported by the package 'spatstat.linnet'.)

Maintained by Adrian Baddeley. Last updated 20 hours ago.

classes-and-objects distance-calculation geometry geometry-processing images mensuration plotting point-patterns spatial-data spatial-data-analysis

8.2 match 7 stars 12.11 score 241 scripts 227 dependents

bioc

clustifyr:Classifier for Single-cell RNA-seq Using Cell Clusters

Package designed to aid in classifying cells from single-cell RNA sequencing data using external reference data (e.g., bulk RNA-seq, scRNA-seq, microarray, gene lists). A variety of correlation based methods and gene list enrichment methods are provided to assist cell type assignment.

Maintained by Rui Fu. Last updated 5 months ago.

singlecell annotation sequencing microarray geneexpression assign-identities clusters marker-genes rna-seq single-cell-rna-seq

10.0 match 119 stars 9.63 score 296 scripts

troyhernandez

tinyspotifyr:Tinyverse R Wrapper for the 'Spotify' Web API

An R wrapper for the 'Spotify' Web API <https://developer.spotify.com/web-api/>.

Maintained by Troy Hernandez. Last updated 1 years ago.

19.8 match 13 stars 4.81 score 5 scripts

r-dbi

DBI:R Database Interface

A database interface definition for communication between R and relational database management systems. All classes in this package are virtual and need to be extended by the various R/DBMS implementations.

Maintained by Kirill Müller. Last updated 3 months ago.

database interface

4.5 match 302 stars 20.88 score 19k scripts 2.9k dependents

cran

frailtypack:Shared, Joint (Generalized) Frailty Models; Surrogate Endpoints

The following several classes of frailty models using a penalized likelihood estimation on the hazard function but also a parametric estimation can be fit using this R package: 1) A shared frailty model (with gamma or log-normal frailty distribution) and Cox proportional hazard model. Clustered and recurrent survival times can be studied. 2) Additive frailty models for proportional hazard models with two correlated random effects (intercept random effect with random slope). 3) Nested frailty models for hierarchically clustered data (with 2 levels of clustering) by including two iid gamma random effects. 4) Joint frailty models in the context of the joint modelling for recurrent events with terminal event for clustered data or not. A joint frailty model for two semi-competing risks and clustered data is also proposed. 5) Joint general frailty models in the context of the joint modelling for recurrent events with terminal event data with two independent frailty terms. 6) Joint Nested frailty models in the context of the joint modelling for recurrent events with terminal event, for hierarchically clustered data (with two levels of clustering) by including two iid gamma random effects. 7) Multivariate joint frailty models for two types of recurrent events and a terminal event. 8) Joint models for longitudinal data and a terminal event. 9) Trivariate joint models for longitudinal data, recurrent events and a terminal event. 10) Joint frailty models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time and/or longitudinal endpoints with the possibility to use a mediation analysis model. 11) Conditional and Marginal two-part joint models for longitudinal semicontinuous data and a terminal event. 12) Joint frailty-copula models for the validation of surrogate endpoints in multiple randomized clinical trials with failure-time endpoints. 13) Generalized shared and joint frailty models for recurrent and terminal events. Proportional hazards (PH), additive hazard (AH), proportional odds (PO) and probit models are available in a fully parametric framework. For PH and AH models, it is possible to consider type-varying coefficients and flexible semiparametric hazard function. Prediction values are available (for a terminal event or for a new recurrent event). Left-truncated (not for Joint model), right-censored data, interval-censored data (only for Cox proportional hazard and shared frailty model) and strata are allowed. In each model, the random effects have the gamma or normal distribution. Now, you can also consider time-varying covariates effects in Cox, shared and joint frailty models (1-5). The package includes concordance measures for Cox proportional hazards models and for shared frailty models. 14) Competing Joint Frailty Model: A single type of recurrent event and two terminal events. 15) functions to compute power and sample size for four Gamma-frailty-based designs: Shared Frailty Models, Nested Frailty Models, Joint Frailty Models, and General Joint Frailty Models. Each design includes two primary functions: a power function, which computes power given a specified sample size; and a sample size function, which computes the required sample size to achieve a specified power. Moreover, the package can be used with its shiny application, in a local mode or by following the link below.

Maintained by Virginie Rondeau. Last updated 11 days ago.

fortran openmp

16.2 match 7 stars 5.56 score 1 dependents

tidyverse

dplyr:A Grammar of Data Manipulation

A fast, consistent tool for working with data frame like objects, both in memory and out of memory.

Maintained by Hadley Wickham. Last updated 14 days ago.

data-manipulation grammar cpp

3.6 match 4.8k stars 24.68 score 659k scripts 7.8k dependents

bioc

KEGGREST:Client-side REST access to the Kyoto Encyclopedia of Genes and Genomes (KEGG)

A package that provides a client interface to the Kyoto Encyclopedia of Genes and Genomes (KEGG) REST API. Only for academic use by academic users belonging to academic institutions (see <https://www.kegg.jp/kegg/rest/>). Note that KEGGREST is based on KEGGSOAP by J. Zhang, R. Gentleman, and Marc Carlson, and KEGG (python package) by Aurelien Mazurie.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation pathways thirdpartyclient kegg bioconductor-package core-package

6.1 match 9 stars 14.46 score 688 scripts 775 dependents

ekstroem

dataMaid:A Suite of Checks for Identification of Potential Errors in a Data Frame as Part of the Data Screening Process

Data screening is an important first step of any statistical analysis. dataMaid auto generates a customizable data report with a thorough summary of the checks and the results that a human can use to identify possible errors. It provides an extendable suite of test for common potential errors in a dataset.

Maintained by Claus Thorn Ekstrøm. Last updated 3 years ago.

data-cleaning data-screening reproducible-research

11.7 match 143 stars 7.53 score 236 scripts

atlasoflivingaustralia

galah:Biodiversity Data from the GBIF Node Network

The Global Biodiversity Information Facility ('GBIF', <https://www.gbif.org>) sources data from an international network of data providers, known as 'nodes'. Several of these nodes - the "living atlases" (<https://living-atlases.gbif.org>) - maintain their own web services using software originally developed by the Atlas of Living Australia ('ALA', <https://www.ala.org.au>). 'galah' enables the R community to directly access data and resources hosted by 'GBIF' and its partner nodes.

Maintained by Martin Westgate. Last updated 1 months ago.

9.6 match 43 stars 9.17 score 275 scripts 1 dependents

rkillick

changepoint:Methods for Changepoint Detection

Implements various mainstream and specialised changepoint methods for finding single and multiple changepoints within data. Many popular non-parametric and frequentist methods are included. The cpt.mean(), cpt.var(), cpt.meanvar() functions should be your first point of call.

Maintained by Rebecca Killick. Last updated 4 months ago.

changepoint segmentation

7.9 match 133 stars 11.05 score 736 scripts 40 dependents

adeckmyn

maps:Draw Geographical Maps

Display of maps. Projection code and larger maps are in separate packages ('mapproj' and 'mapdata').

Maintained by Alex Deckmyn. Last updated 2 months ago.

5.9 match 24 stars 14.70 score 19k scripts 490 dependents

therneau

survival:Survival Analysis

Contains the core survival analysis routines, including definition of Surv objects, Kaplan-Meier and Aalen-Johansen (multi-state) curves, Cox models, and parametric accelerated failure time models.

Maintained by Terry M Therneau. Last updated 3 months ago.

4.3 match 400 stars 20.43 score 29k scripts 3.9k dependents

cboettig

contentid:An Interface for Content-Based Identifiers

An interface for creating, registering, and resolving content-based identifiers for data management. Content-based identifiers rely on the 'cryptographic' hashes to refer to the files they identify, thus, anyone possessing the file can compute the identifier using a well-known standard algorithm, such as 'SHA256'. By registering a URL at which the content is accessible to a public archive (such as Hash Archive) or depositing data in a scientific repository such 'Zenodo', 'DataONE' or 'SoftwareHeritage', the content identifier can serve many functions typically associated with A Digital Object Identifier ('DOI'). Unlike location-based identifiers like 'DOIs', content-based identifiers permit the same content to be registered in many locations.

Maintained by Carl Boettiger. Last updated 2 months ago.

11.3 match 46 stars 7.59 score 108 scripts 3 dependents

bioc

RCy3:Functions to Access and Control Cytoscape

Vizualize, analyze and explore networks using Cytoscape via R. Anything you can do using the graphical user interface of Cytoscape, you can now do with a single RCy3 function.

Maintained by Alex Pico. Last updated 5 months ago.

visualization graphandnetwork thirdpartyclient network

6.4 match 52 stars 13.39 score 628 scripts 15 dependents

bioc

GOexpress:Visualise microarray and RNAseq data using gene ontology annotations

The package contains methods to visualise the expression profile of genes from a microarray or RNA-seq experiment, and offers a supervised clustering approach to identify GO terms containing genes with expression levels that best classify two or more predefined groups of samples. Annotations for the genes present in the expression dataset may be obtained from Ensembl through the biomaRt package, if not provided by the user. The default random forest framework is used to evaluate the capacity of each gene to cluster samples according to the factor of interest. Finally, GO terms are scored by averaging the rank (alternatively, score) of their respective gene sets to cluster the samples. P-values may be computed to assess the significance of GO term ranking. Visualisation function include gene expression profile, gene ontology-based heatmaps, and hierarchical clustering of experimental samples using gene expression data.

Maintained by Kevin Rue-Albrecht. Last updated 5 months ago.

software geneexpression transcription differentialexpression genesetenrichment datarepresentation clustering timecourse microarray sequencing rnaseq annotation multiplecomparison pathways go visualization immunooncology bioconductor bioconductor-package bioconductor-stats geneontology geneset-enrichment

12.3 match 9 stars 6.75 score 31 scripts

marksendak

constellation:Identify Event Sequences Using Time Series Joins

Examine any number of time series data frames to identify instances in which various criteria are met within specified time frames. In clinical medicine, these types of events are often called "constellations of signs and symptoms", because a single condition depends on a series of events occurring within a certain amount of time of each other. This package was written to work with any number of time series data frames and is optimized for speed to work well with data frames with millions of rows.

Maintained by Mark Sendak. Last updated 6 years ago.

electronic-health-record electronic-health-records healthcare patients timeseries

17.2 match 6 stars 4.76 score 19 scripts

bioc

MassSpecWavelet:Peak Detection for Mass Spectrometry data using wavelet-based algorithms

Peak Detection in Mass Spectrometry data is one of the important preprocessing steps. The performance of peak detection affects subsequent processes, including protein identification, profile alignment and biomarker identification. Using Continuous Wavelet Transform (CWT), this package provides a reliable algorithm for peak detection that does not require any type of smoothing or previous baseline correction method, providing more consistent results for different spectra. See <doi:10.1093/bioinformatics/btl355} for further details.

Maintained by Sergio Oller Moreno. Last updated 3 months ago.

immunooncology massspectrometry proteomics peakdetection

8.7 match 9 stars 9.38 score 37 scripts 17 dependents

rosieluain

mort:Identifying Potential Mortalities and Expelled Tags in Aquatic Acoustic Telemetry Arrays

A toolkit for identifying potential mortalities and expelled tags in aquatic acoustic telemetry arrays. Designed for arrays with non-overlapping receivers.

Maintained by Rosie Smith. Last updated 6 months ago.

acoustic-telemetry aquatic mortality-estimation

15.2 match 4 stars 5.35 score 16 scripts

ropensci

oai:General Purpose 'Oai-PMH' Services Client

A general purpose client to work with any 'OAI-PMH' (Open Archives Initiative Protocol for 'Metadata' Harvesting) service. The 'OAI-PMH' protocol is described at <http://www.openarchives.org/OAI/openarchivesprotocol.html>. Functions are provided to work with the 'OAI-PMH' verbs: 'GetRecord', 'Identify', 'ListIdentifiers', 'ListMetadataFormats', 'ListRecords', and 'ListSets'.

Maintained by Michal Bojanowski. Last updated 2 years ago.

data-access oai-pmh peer-reviewed scholarly-api

9.4 match 15 stars 8.55 score 23 scripts 24 dependents

svilsen

STRMPS:Analysis of Short Tandem Repeat (STR) Massively Parallel Sequencing (MPS) Data

Loading, identifying, aggregating, manipulating, and analysing short tandem repeat regions of massively parallel sequencing data in forensic genetics. The analyses and framework implemented in this package relies on the papers of Vilsen et al. (2017) <doi:10.1016/j.fsigen.2017.01.017> and Vilsen et al. (2018) <doi:10.1016/j.fsigen.2018.04.003>. Note: that the parallelisation in the package relies on mclapply() and, thus, speed-ups will only be seen on UNIX based systems.

Maintained by Søren B. Vilsen. Last updated 4 days ago.

biostrings pwalign shortread iranges

18.4 match 4.30 score

ropensci

datapack:A Flexible Container to Transport and Manipulate Data and Associated Resources

Provides a flexible container to transport and manipulate complex sets of data. These data may consist of multiple data files and associated meta data and ancillary files. Individual data objects have associated system level meta data, and data files are linked together using the OAI-ORE standard resource map which describes the relationships between the files. The OAI- ORE standard is described at <https://www.openarchives.org/ore/>. Data packages can be serialized and transported as structured files that have been created following the BagIt specification. The BagIt specification is described at <https://tools.ietf.org/html/draft-kunze-bagit-08>.

Maintained by Matthew B. Jones. Last updated 3 years ago.

9.2 match 44 stars 8.56 score 195 scripts 4 dependents

bioc

Gviz:Plotting data and annotation information along genomic coordinates

Genomic data analyses requires integrated visualization of known genomic information and new experimental data. Gviz uses the biomaRt and the rtracklayer packages to perform live annotation queries to Ensembl and UCSC and translates this to e.g. gene/transcript structures in viewports of the grid graphics package. This results in genomic information plotted together with your data.

Maintained by Robert Ivanek. Last updated 5 months ago.

visualization microarray sequencing

6.0 match 79 stars 13.08 score 1.4k scripts 48 dependents

moosa-r

rbioapi:User-Friendly R Interface to Biologic Web Services' API

Currently fully supports Enrichr, JASPAR, miEAA, PANTHER, Reactome, STRING, and UniProt! The goal of rbioapi is to provide a user-friendly and consistent interface to biological databases and services. In a way that insulates the user from the technicalities of using web services API and creates a unified and easy-to-use interface to biological and medical web services. This is an ongoing project; New databases and services will be added periodically. Feel free to suggest any databases or services you often use.

Maintained by Moosa Rezwani. Last updated 1 months ago.

api-client bioinformatics biology enrichment enrichment-analysis enrichr jaspar mieaa over-representation-analysis panther reactome string uniprot

10.2 match 20 stars 7.60 score 55 scripts

ropensci

ritis:Integrated Taxonomic Information System Client

An interface to the Integrated Taxonomic Information System ('ITIS') (<https://www.itis.gov>). Includes functions to work with the 'ITIS' REST API methods (<https://www.itis.gov/ws_description.html>), as well as the 'Solr' web service (<https://www.itis.gov/solr_documentation.html>).

Maintained by Julia Blum. Last updated 1 months ago.

taxonomy biology nomenclature json api web api-client identifiers species names api-wrapper itis taxize

10.0 match 16 stars 7.72 score 64 scripts 24 dependents

dataobservatory-eu

dataset:Create Data Frames that are Easier to Exchange and Reuse

The aim of the 'dataset' package is to make tidy datasets easier to release, exchange and reuse. It organizes and formats data frame 'R' objects into well-referenced, well-described, interoperable datasets into release and reuse ready form.

Maintained by Daniel Antal. Last updated 21 days ago.

dataset metadata-management

9.9 match 15 stars 7.81 score 76 scripts 1 dependents

ncbi-hackathons

geneHummus:A Pipeline to Define Gene Families in Legumes and Beyond

A pipeline with high specificity and sensitivity in extracting proteins from the RefSeq database (National Center for Biotechnology Information). Manual identification of gene families is highly time-consuming and laborious, requiring an iterative process of manual and computational analysis to identify members of a given family. The pipelines implements an automatic approach for the identification of gene families based on the conserved domains that specifically define that family. See Die et al. (2018) <doi:10.1101/436659> for more information and examples.

Maintained by Jose V. Die. Last updated 5 years ago.

18.3 match 8 stars 4.20 score 3 scripts

bioc

topGO:Enrichment Analysis for Gene Ontology

topGO package provides tools for testing GO terms while accounting for the topology of the GO graph. Different test statistics and different methods for eliminating local similarities and dependencies between GO terms can be implemented and applied.

Maintained by Adrian Alexa. Last updated 5 months ago.

microarray visualization

8.5 match 8.96 score 2.0k scripts 20 dependents

eltoulemonde

dataPreparation:Automated Data Preparation

Do most of the painful data preparation for a data science project with a minimum amount of code; Take advantages of 'data.table' efficiency and use some algorithmic trick in order to perform data preparation in a time and RAM efficient way.

Maintained by Emmanuel-Lin Toulemonde. Last updated 2 years ago.

data-preparation data-preprocessing data-science date-conversion speed variable-elimination variable-selection

13.9 match 31 stars 5.46 score 86 scripts

bioc

segmentSeq:Methods for identifying small RNA loci from high-throughput sequencing data

High-throughput sequencing technologies allow the production of large volumes of short sequences, which can be aligned to the genome to create a set of matches to the genome. By looking for regions of the genome which to which there are high densities of matches, we can infer a segmentation of the genome into regions of biological significance. The methods in this package allow the simultaneous segmentation of data from multiple samples, taking into account replicate data, in order to create a consensus segmentation. This has obvious applications in a number of classes of sequencing experiments, particularly in the discovery of small RNA loci and novel mRNA transcriptome discovery.

Maintained by Samuel Granjeaud. Last updated 4 months ago.

multiplecomparison sequencing alignment differentialexpression qualitycontrol dataimport

12.3 match 6.17 score 42 scripts

henrikbengtsson

R.utils:Various Programming Utilities

Utility functions useful when programming and developing R packages.

Maintained by Henrik Bengtsson. Last updated 1 years ago.

5.5 match 63 stars 13.74 score 5.7k scripts 814 dependents

ts404

WikidataR:Read-Write API Client Library for Wikidata

Read from, interrogate, and write to Wikidata <https://www.wikidata.org> - the multilingual, interdisciplinary, semantic knowledgebase. Includes functions to: read from Wikidata (single items, properties, or properties); query Wikidata (retrieving all items that match a set of criteria via Wikidata SPARQL query service); write to Wikidata (adding new items or statements via QuickStatements); and handle and manipulate Wikidata objects (as lists and tibbles). Uses the Wikidata and QuickStatements APIs.

Maintained by Thomas Shafee. Last updated 2 months ago.

api-client wikidata

8.6 match 22 stars 8.64 score 109 scripts 25 dependents

rnabioco

valr:Genome Interval Arithmetic

Read and manipulate genome intervals and signals. Provides functionality similar to command-line tool suites within R, enabling interactive analysis and visualization of genome-scale data. Riemondy et al. (2017) <doi:10.12688/f1000research.11997.1>.

Maintained by Kent Riemondy. Last updated 8 days ago.

bedtools genome interval-arithmetic cpp

7.6 match 90 stars 9.69 score 227 scripts

santikka

causaleffect:Deriving Expressions of Joint Interventional Distributions and Transport Formulas in Causal Models

Functions for identification and transportation of causal effects. Provides a conditional causal effect identification algorithm (IDC) by Shpitser, I. and Pearl, J. (2006) <http://ftp.cs.ucla.edu/pub/stat_ser/r329-uai.pdf>, an algorithm for transportability from multiple domains with limited experiments by Bareinboim, E. and Pearl, J. (2014) <http://ftp.cs.ucla.edu/pub/stat_ser/r443.pdf>, and a selection bias recovery algorithm by Bareinboim, E. and Tian, J. (2015) <http://ftp.cs.ucla.edu/pub/stat_ser/r445.pdf>. All of the previously mentioned algorithms are based on a causal effect identification algorithm by Tian , J. (2002) <http://ftp.cs.ucla.edu/pub/stat_ser/r309.pdf>.

Maintained by Santtu Tikka. Last updated 2 years ago.

causal-inference causal-models causality-algorithms directed-acyclic-graph graphs identifiability identification igraph

13.8 match 29 stars 5.28 score 44 scripts 1 dependents

ekstroem

dataReporter:Reproducible Data Screening Checks and Report of Possible Errors

Data screening is an important first step of any statistical analysis. 'dataReporter' auto generates a customizable data report with a thorough summary of the checks and the results that a human can use to identify possible errors. It provides an extendable suite of test for common potential errors in a dataset. See Petersen AH, Ekstrøm CT (2019). "dataMaid: Your Assistant for Documenting Supervised Data Quality Screening in R." _Journal of Statistical Software_, *90*(6), 1-38 <doi:10.18637/jss.v090.i06> for more information.

Maintained by Claus Thorn Ekstrøm. Last updated 2 years ago.

11.7 match 86 stars 6.16 score 34 scripts

snoweye

phyclust:Phylogenetic Clustering (Phyloclustering)

Phylogenetic clustering (phyloclustering) is an evolutionary Continuous Time Markov Chain model-based approach to identify population structure from molecular data without assuming linkage equilibrium. The package phyclust (Chen 2011) provides a convenient implementation of phyloclustering for DNA and SNP data, capable of clustering individuals into subpopulations and identifying molecular sequences representative of those subpopulations. It is designed in C for performance, interfaced with R for visualization, and incorporates other popular open source programs including ms (Hudson 2002) <doi:10.1093/bioinformatics/18.2.337>, seq-gen (Rambaut and Grassly 1997) <doi:10.1093/bioinformatics/13.3.235>, Hap-Clustering (Tzeng 2005) <doi:10.1002/gepi.20063> and PAML baseml (Yang 1997, 2007) <doi:10.1093/bioinformatics/13.5.555>, <doi:10.1093/molbev/msm088>, for simulating data, additional analyses, and searching the best tree. See the phyclust website for more information, documentations and examples.

Maintained by Wei-Chen Chen. Last updated 2 years ago.

8.5 match 9 stars 8.45 score 126 scripts 8 dependents

doi-usgs

sbtools:USGS ScienceBase Tools

Tools for interacting with U.S. Geological Survey ScienceBase <https://www.sciencebase.gov> interfaces. ScienceBase is a data cataloging and collaborative data management platform. Functions included for querying ScienceBase, and creating and fetching datasets.

Maintained by David Blodgett. Last updated 10 months ago.

sciencebase usgs

9.0 match 21 stars 7.94 score 127 scripts 2 dependents

walkerke

tidycensus:Load US Census Boundary and Attribute Data as 'tidyverse' and 'sf'-Ready Data Frames

An integrated R interface to several United States Census Bureau APIs (<https://www.census.gov/data/developers/data-sets.html>) and the US Census Bureau's geographic boundary files. Allows R users to return Census and ACS data as tidyverse-ready data frames, and optionally returns a list-column with feature geometry for mapping and spatial analysis.

Maintained by Kyle Walker. Last updated 2 months ago.

5.0 match 647 stars 14.27 score 7.5k scripts 10 dependents

bioc

dada2:Accurate, high-resolution sample inference from amplicon sequencing data

The dada2 package infers exact amplicon sequence variants (ASVs) from high-throughput amplicon sequencing data, replacing the coarser and less accurate OTU clustering approach. The dada2 pipeline takes as input demultiplexed fastq files, and outputs the sequence variants and their sample-wise abundances after removing substitution and chimera errors. Taxonomic classification is available via a native implementation of the RDP naive Bayesian classifier, and species-level assignment to 16S rRNA gene fragments by exact matching.

Maintained by Benjamin Callahan. Last updated 5 months ago.

immunooncology microbiome sequencing classification metagenomics amplicon bioconductor bioinformatics metabarcoding taxonomy cpp

5.4 match 485 stars 13.17 score 3.0k scripts 4 dependents

bioc

IsoformSwitchAnalyzeR:Identify, Annotate and Visualize Isoform Switches with Functional Consequences from both short- and long-read RNA-seq data

Analysis of alternative splicing and isoform switches with predicted functional consequences (e.g. gain/loss of protein domains etc.) from quantification of all types of RNASeq by tools such as Kallisto, Salmon, StringTie, Cufflinks/Cuffdiff etc.

Maintained by Kristoffer Vitting-Seerup. Last updated 5 months ago.

geneexpression transcription alternativesplicing differentialexpression differentialsplicing visualization statisticalmethod transcriptomevariant biomedicalinformatics functionalgenomics systemsbiology transcriptomics rnaseq annotation functionalprediction geneprediction dataimport multiplecomparison batcheffect immunooncology

7.5 match 108 stars 9.26 score 125 scripts

bioc

miRspongeR:Identification and analysis of miRNA sponge regulation

This package provides several functions to explore miRNA sponge (also called ceRNA or miRNA decoy) regulation from putative miRNA-target interactions or/and transcriptomics data (including bulk, single-cell and spatial gene expression data). It provides eight popular methods for identifying miRNA sponge interactions, and an integrative method to integrate miRNA sponge interactions from different methods, as well as the functions to validate miRNA sponge interactions, and infer miRNA sponge modules, conduct enrichment analysis of miRNA sponge modules, and conduct survival analysis of miRNA sponge modules. By using a sample control variable strategy, it provides a function to infer sample-specific miRNA sponge interactions. In terms of sample-specific miRNA sponge interactions, it implements three similarity methods to construct sample-sample correlation network.

Maintained by Junpeng Zhang. Last updated 5 months ago.

geneexpression biomedicalinformatics networkenrichment survival microarray software singlecell spatial rnaseq cerna mirna sponge

11.7 match 5 stars 5.88 score 8 scripts

santikka

cfid:Identification of Counterfactual Queries in Causal Models

Facilitates the identification of counterfactual queries in structural causal models via the ID* and IDC* algorithms by Shpitser, I. and Pearl, J. (2007, 2008) <arXiv:1206.5294>, <https://jmlr.org/papers/v9/shpitser08a.html>. Provides a simple interface for defining causal diagrams and counterfactual conjunctions. Construction of parallel worlds graphs and counterfactual graphs is carried out automatically based on the counterfactual query and the causal diagram. See Tikka, S. (2023) <doi:10.32614/RJ-2023-053> for a tutorial of the package.

Maintained by Santtu Tikka. Last updated 8 months ago.

causal-inference causal-models causality-algorithms counterfactual counterfactuals directed-acyclic-graph identifiability

16.9 match 7 stars 4.02 score 2 scripts 1 dependents

ropensci

redland:RDF Library Bindings in R

Provides methods to parse, query and serialize information stored in the Resource Description Framework (RDF). RDF is described at <https://www.w3.org/TR/rdf-primer/>. This package supports RDF by implementing an R interface to the Redland RDF C library, described at <https://librdf.org/docs/api/index.html>. In brief, RDF provides a structured graph consisting of Statements composed of Subject, Predicate, and Object Nodes.

Maintained by Matthew B. Jones. Last updated 1 years ago.

redland

8.5 match 17 stars 7.85 score 98 scripts 13 dependents

opengeos

whitebox:'WhiteboxTools' R Frontend

An R frontend for the 'WhiteboxTools' library, which is an advanced geospatial data analysis platform developed by Prof. John Lindsay at the University of Guelph's Geomorphometry and Hydrogeomatics Research Group. 'WhiteboxTools' can be used to perform common geographical information systems (GIS) analysis operations, such as cost-distance analysis, distance buffering, and raster reclassification. Remote sensing and image processing tasks include image enhancement (e.g. panchromatic sharpening, contrast adjustments), image mosaicing, numerous filtering operations, simple classification (k-means), and common image transformations. 'WhiteboxTools' also contains advanced tooling for spatial hydrological analysis (e.g. flow-accumulation, watershed delineation, stream network analysis, sink removal), terrain analysis (e.g. common terrain indices such as slope, curvatures, wetness index, hillshading; hypsometric analysis; multi-scale topographic position analysis), and LiDAR data processing. Suggested citation: Lindsay (2016) <doi:10.1016/j.cageo.2016.07.003>.

Maintained by Andrew Brown. Last updated 5 months ago.

geomorphometry geoprocessing geospatial gis hydrology remote-sensing rstudio

6.9 match 173 stars 9.65 score 203 scripts 2 dependents

kharchenkolab

pagoda2:Single Cell Analysis and Differential Expression

Analyzing and interactively exploring large-scale single-cell RNA-seq datasets. 'pagoda2' primarily performs normalization and differential gene expression analysis, with an interactive application for exploring single-cell RNA-seq datasets. It performs basic tasks such as cell size normalization, gene variance normalization, and can be used to identify subpopulations and run differential expression within individual samples. 'pagoda2' was written to rapidly process modern large-scale scRNAseq datasets of approximately 1e6 cells. The companion web application allows users to explore which gene expression patterns form the different subpopulations within your data. The package also serves as the primary method for preprocessing data for conos, <https://github.com/kharchenkolab/conos>. This package interacts with data available through the 'p2data' package, which is available in a 'drat' repository. To access this data package, see the instructions at <https://github.com/kharchenkolab/pagoda2>. The size of the 'p2data' package is approximately 6 MB.

Maintained by Evan Biederstedt. Last updated 1 years ago.

scrna-seq single-cell single-cell-rna-seq transcriptomics openblas cpp openmp

8.3 match 222 stars 8.00 score 282 scripts

robjhyndman

forecast:Forecasting Functions for Time Series and Linear Models

Methods and tools for displaying and analysing univariate time series forecasts including exponential smoothing via state space models and automatic ARIMA modelling.

Maintained by Rob Hyndman. Last updated 7 months ago.

forecast forecasting openblas cpp

3.5 match 1.1k stars 18.63 score 16k scripts 239 dependents

usepa

httk:High-Throughput Toxicokinetics

Pre-made models that can be rapidly tailored to various chemicals and species using chemical-specific in vitro data and physiological information. These tools allow incorporation of chemical toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE") into bioinformatics, as described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>). Chemical-specific in vitro data characterizing toxicokinetics have been obtained from relatively high-throughput experiments. The chemical-independent ("generic") physiologically-based ("PBTK") and empirical (for example, one compartment) "TK" models included here can be parameterized with in vitro data or in silico predictions which are provided for thousands of chemicals, multiple exposure routes, and various species. High throughput toxicokinetics ("HTTK") is the combination of in vitro data and generic models. We establish the expected accuracy of HTTK for chemicals without in vivo data through statistical evaluation of HTTK predictions for chemicals where in vivo data do exist. The models are systems of ordinary differential equations that are developed in MCSim and solved using compiled (C-based) code for speed. A Monte Carlo sampler is included for simulating human biological variability (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) and propagating parameter uncertainty (Wambaugh et al., 2019 <doi:10.1093/toxsci/kfz205>). Empirically calibrated methods are included for predicting tissue:plasma partition coefficients and volume of distribution (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). These functions and data provide a set of tools for using IVIVE to convert concentrations from high-throughput screening experiments (for example, Tox21, ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK") (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).

Maintained by John Wambaugh. Last updated 1 months ago.

comptox ord

6.4 match 27 stars 10.22 score 307 scripts 1 dependents

bioc

sesame:SEnsible Step-wise Analysis of DNA MEthylation BeadChips

Tools For analyzing Illumina Infinium DNA methylation arrays. SeSAMe provides utilities to support analyses of multiple generations of Infinium DNA methylation BeadChips, including preprocessing, quality control, visualization and inference. SeSAMe features accurate detection calling, intelligent inference of ethnicity, sex and advanced quality control routines.

Maintained by Wanding Zhou. Last updated 2 months ago.

dnamethylation methylationarray preprocessing qualitycontrol bioinformatics dna-methylation microarray

7.1 match 69 stars 9.08 score 258 scripts 1 dependents

milanwiedemann

suddengains:Identify Sudden Gains in Longitudinal Data

Identify sudden gains based on the three criteria outlined by Tang and DeRubeis (1999) <doi:10.1037/0022-006X.67.6.894> to a selection of repeated measures. Sudden losses, defined as the opposite of sudden gains can also be identified. Two different datasets can be created, one including all sudden gains/losses and one including one selected sudden gain/loss for each case. It can extract scores around sudden gains/losses. It can plot the average change around sudden gains/losses and trajectories of individual cases.

Maintained by Milan Wiedemann. Last updated 2 years ago.

change-detection sudden-gains sudden-losses

12.4 match 7 stars 5.15 score 10 scripts

tidymodels

rsample:General Resampling Infrastructure

Classes and functions to create and summarize different types of resampling objects (e.g. bootstrap, cross-validation).

Maintained by Hannah Frick. Last updated 6 days ago.

3.8 match 341 stars 16.72 score 5.2k scripts 79 dependents

yulab-smu

ggfun:Miscellaneous Functions for 'ggplot2'

Useful functions and utilities for 'ggplot' object (e.g., geometric layers, themes, and utilities to edit the object).

Maintained by Guangchuang Yu. Last updated 1 days ago.

6.0 match 18 stars 10.53 score 58 scripts 152 dependents

blasbenito

collinear:Automated Multicollinearity Management

Effortless multicollinearity management in data frames with both numeric and categorical variables for statistical and machine learning applications. The package simplifies multicollinearity analysis by combining four robust methods: 1) target encoding for categorical variables (Micci-Barreca, D. 2001 <doi:10.1145/507533.507538>); 2) automated feature prioritization to prevent key variable loss during filtering; 3) pairwise correlation for all variable combinations (numeric-numeric, numeric-categorical, categorical-categorical); and 4) fast computation of variance inflation factors.

Maintained by Blas M. Benito. Last updated 2 months ago.

machine-learning multicollinearity statistics

11.4 match 11 stars 5.51 score 15 scripts 1 dependents

r-lib

lintr:A 'Linter' for R Code

Checks adherence to a given style, syntax errors and possible semantic issues. Supports on the fly checking of R code edited with 'RStudio IDE', 'Emacs', 'Vim', 'Sublime Text', 'Atom' and 'Visual Studio Code'.

Maintained by Michael Chirico. Last updated 7 hours ago.

linter

3.7 match 1.2k stars 16.99 score 916 scripts 33 dependents

bioc

flowCore:flowCore: Basic structures for flow cytometry data

Provides S4 data structures and basic functions to deal with flow cytometry data.

Maintained by Mike Jiang. Last updated 5 months ago.

immunooncology infrastructure flowcytometry cellbasedassays cpp

6.0 match 10.34 score 1.7k scripts 59 dependents

interstellar-consultation-services

covid19dbcand:Selected 'Drugbank' Drugs for COVID-19 Treatment Related Data in R Format

Provides different datasets parsed from 'Drugbank' <https://www.drugbank.ca/covid-19> database using 'dbparser' package. It is a smaller version from 'dbdataset' package. It contains only information about COVID-19 possible treatment.

Maintained by Mohammed Ali. Last updated 11 months ago.

dataset dbparser drugbank drugbank-database

13.7 match 3 stars 4.48 score 6 scripts

bioc

rTRM:Identification of Transcriptional Regulatory Modules from Protein-Protein Interaction Networks

rTRM identifies transcriptional regulatory modules (TRMs) from protein-protein interaction networks.

Maintained by Diego Diez. Last updated 5 months ago.

transcription network generegulation graphandnetwork bioconductor bioinformatics

12.6 match 3 stars 4.86 score 3 scripts 1 dependents

bioc

annotate:Annotation for microarrays

Using R enviroments for annotation.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation pathways go

5.3 match 11.41 score 812 scripts 243 dependents

bnosac

udpipe:Tokenization, Parts of Speech Tagging, Lemmatization and Dependency Parsing with the 'UDPipe' 'NLP' Toolkit

This natural language processing toolkit provides language-agnostic 'tokenization', 'parts of speech tagging', 'lemmatization' and 'dependency parsing' of raw text. Next to text parsing, the package also allows you to train annotation models based on data of 'treebanks' in 'CoNLL-U' format as provided at <https://universaldependencies.org/format.html>. The techniques are explained in detail in the paper: 'Tokenizing, POS Tagging, Lemmatizing and Parsing UD 2.0 with UDPipe', available at <doi:10.18653/v1/K17-3009>. The toolkit also contains functionalities for commonly used data manipulations on texts which are enriched with the output of the parser. Namely functionalities and algorithms for collocations, token co-occurrence, document term matrix handling, term frequency inverse document frequency calculations, information retrieval metrics (Okapi BM25), handling of multi-word expressions, keyword detection (Rapid Automatic Keyword Extraction, noun phrase extraction, syntactical patterns) sentiment scoring and semantic similarity analysis.

Maintained by Jan Wijffels. Last updated 2 years ago.

conll dependency-parser lemmatization natural-language-processing nlp pos-tagging r-pkg rcpp text-mining tokenizer udpipe cpp

5.1 match 215 stars 11.83 score 1.2k scripts 9 dependents

darwin-eu

PatientProfiles:Identify Characteristics of Patients in the OMOP Common Data Model

Identify the characteristics of patients in data mapped to the Observational Medical Outcomes Partnership (OMOP) common data model.

Maintained by Marti Catala. Last updated 11 days ago.

6.0 match 1 stars 9.97 score 225 scripts 9 dependents

bioc

CoreGx:Classes and Functions to Serve as the Basis for Other 'Gx' Packages

A collection of functions and classes which serve as the foundation for our lab's suite of R packages, such as 'PharmacoGx' and 'RadioGx'. This package was created to abstract shared functionality from other lab package releases to increase ease of maintainability and reduce code repetition in current and future 'Gx' suite programs. Major features include a 'CoreSet' class, from which 'RadioSet' and 'PharmacoSet' are derived, along with get and set methods for each respective slot. Additional functions related to fitting and plotting dose response curves, quantifying statistical correlation and calculating area under the curve (AUC) or survival fraction (SF) are included. For more details please see the included documentation, as well as: Smirnov, P., Safikhani, Z., El-Hachem, N., Wang, D., She, A., Olsen, C., Freeman, M., Selby, H., Gendoo, D., Grossman, P., Beck, A., Aerts, H., Lupien, M., Goldenberg, A. (2015) <doi:10.1093/bioinformatics/btv723>. Manem, V., Labie, M., Smirnov, P., Kofia, V., Freeman, M., Koritzinksy, M., Abazeed, M., Haibe-Kains, B., Bratman, S. (2018) <doi:10.1101/449793>.

Maintained by Benjamin Haibe-Kains. Last updated 5 months ago.

software pharmacogenomics classification survival

8.9 match 6.53 score 63 scripts 6 dependents

bioc

SPIAT:Spatial Image Analysis of Tissues

SPIAT (**Sp**atial **I**mage **A**nalysis of **T**issues) is an R package with a suite of data processing, quality control, visualization and data analysis tools. SPIAT is compatible with data generated from single-cell spatial proteomics platforms (e.g. OPAL, CODEX, MIBI, cellprofiler). SPIAT reads spatial data in the form of X and Y coordinates of cells, marker intensities and cell phenotypes. SPIAT includes six analysis modules that allow visualization, calculation of cell colocalization, categorization of the immune microenvironment relative to tumor areas, analysis of cellular neighborhoods, and the quantification of spatial heterogeneity, providing a comprehensive toolkit for spatial data analysis.

Maintained by Yuzhou Feng. Last updated 2 days ago.

biomedicalinformatics cellbiology spatial clustering dataimport immunooncology qualitycontrol singlecell software visualization

6.8 match 22 stars 8.59 score 69 scripts

shixiangwang

IDConverter:Convert Identifiers in Biological Databases

Identifiers in biological databases connect different levels of metadata, phenotype data or genotype data. This tool is designed to easily convert identifiers within or between different biological databases (Wang, Shixiang, et al. (2021) <DOI:10.1371/journal.pgen.1009557>).

Maintained by Shixiang Wang. Last updated 2 years ago.

19.4 match 9 stars 3.00 score 22 scripts

bioc

doppelgangR:Identify likely duplicate samples from genomic or meta-data

The main function is doppelgangR(), which takes as minimal input a list of ExpressionSet object, and searches all list pairs for duplicated samples. The search is based on the genomic data (exprs(eset)), phenotype/clinical data (pData(eset)), and "smoking guns" - supposedly unique identifiers found in pData(eset).

Maintained by Levi Waldron. Last updated 5 months ago.

immunooncology rnaseq microarray geneexpression qualitycontrol bioconductor-package

8.7 match 5 stars 6.67 score 31 scripts

bioc

derfinder:Annotation-agnostic differential expression analysis of RNA-seq data at base-pair resolution via the DER Finder approach

This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package: (1) single base-level F-statistics and (2) DER identification at the expressed regions-level. The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.

Maintained by Leonardo Collado-Torres. Last updated 3 months ago.

differentialexpression sequencing rnaseq chipseq differentialpeakcalling software immunooncology coverage annotation-agnostic bioconductor derfinder

5.6 match 42 stars 10.03 score 78 scripts 6 dependents

reconhub

epicontacts:Handling, Visualisation and Analysis of Epidemiological Contacts

A collection of tools for representing epidemiological contact data, composed of case line lists and contacts between cases. Also contains procedures for data handling, interactive graphics, and statistics.

Maintained by Finlay Campbell. Last updated 2 months ago.

outbreak

6.4 match 15 stars 8.86 score 112 scripts 2 dependents

ms609

TreeTools:Create, Modify and Analyse Phylogenetic Trees

Efficient implementations of functions for the creation, modification and analysis of phylogenetic trees. Applications include: generation of trees with specified shapes; tree rearrangement; analysis of tree shape; rooting of trees and extraction of subtrees; calculation and depiction of split support; plotting the position of rogue taxa (Klopfstein & Spasojevic 2019) <doi:10.1371/journal.pone.0212942>; calculation of ancestor-descendant relationships, of 'stemwardness' (Asher & Smith, 2022) <doi:10.1093/sysbio/syab072>, and of tree balance (Mir et al. 2013, Lemant et al. 2022) <doi:10.1016/j.mbs.2012.10.005>, <doi:10.1093/sysbio/syac027>; artificial extinction (Asher & Smith, 2022) <doi:10.1093/sysbio/syab072>; import and export of trees from Newick, Nexus (Maddison et al. 1997) <doi:10.1093/sysbio/46.4.590>, and TNT <https://www.lillo.org.ar/phylogeny/tnt/> formats; and analysis of splits and cladistic information.

Maintained by Martin R. Smith. Last updated 1 months ago.

evolutionary-biology phylogenetic-trees phylogenetics cpp

5.7 match 21 stars 9.92 score 124 scripts 10 dependents

daattali

ddpcr:Analysis and Visualization of Droplet Digital PCR in R and on the Web

An interface to explore, analyze, and visualize droplet digital PCR (ddPCR) data in R. This is the first non-proprietary software for analyzing two-channel ddPCR data. An interactive tool was also created and is available online to facilitate this analysis for anyone who is not comfortable with using R.

Maintained by Dean Attali. Last updated 12 months ago.

5.9 match 61 stars 9.54 score 131 scripts 2 dependents

bioc

ISAnalytics:Analyze gene therapy vector insertion sites data identified from genomics next generation sequencing reads for clonal tracking studies

In gene therapy, stem cells are modified using viral vectors to deliver the therapeutic transgene and replace functional properties since the genetic modification is stable and inherited in all cell progeny. The retrieval and mapping of the sequences flanking the virus-host DNA junctions allows the identification of insertion sites (IS), essential for monitoring the evolution of genetically modified cells in vivo. A comprehensive toolkit for the analysis of IS is required to foster clonal trackign studies and supporting the assessment of safety and long term efficacy in vivo. This package is aimed at (1) supporting automation of IS workflow, (2) performing base and advance analysis for IS tracking (clonal abundance, clonal expansions and statistics for insertional mutagenesis, etc.), (3) providing basic biology insights of transduced stem cells in vivo.

Maintained by Francesco Gazzo. Last updated 3 months ago.

biomedicalinformatics sequencing singlecell

9.6 match 3 stars 5.83 score 15 scripts

spatstat

spatstat.linnet:Linear Networks Functionality of the 'spatstat' Family

Defines types of spatial data on a linear network and provides functionality for geometrical operations, data analysis and modelling of data on a linear network, in the 'spatstat' family of packages. Contains definitions and support for linear networks, including creation of networks, geometrical measurements, topological connectivity, geometrical operations such as inserting and deleting vertices, intersecting a network with another object, and interactive editing of networks. Data types defined on a network include point patterns, pixel images, functions, and tessellations. Exploratory methods include kernel estimation of intensity on a network, K-functions and pair correlation functions on a network, simulation envelopes, nearest neighbour distance and empty space distance, relative risk estimation with cross-validated bandwidth selection. Formal hypothesis tests of random pattern (chi-squared, Kolmogorov-Smirnov, Monte Carlo, Diggle-Cressie-Loosmore-Ford, Dao-Genton, two-stage Monte Carlo) and tests for covariate effects (Cox-Berman-Waller-Lawson, Kolmogorov-Smirnov, ANOVA) are also supported. Parametric models can be fitted to point pattern data using the function lppm() similar to glm(). Only Poisson models are implemented so far. Models may involve dependence on covariates and dependence on marks. Models are fitted by maximum likelihood. Fitted point process models can be simulated, automatically. Formal hypothesis tests of a fitted model are supported (likelihood ratio test, analysis of deviance, Monte Carlo tests) along with basic tools for model selection (stepwise(), AIC()) and variable selection (sdr). Tools for validating the fitted model include simulation envelopes, residuals, residual plots and Q-Q plots, leverage and influence diagnostics, partial residuals, and added variable plots. Random point patterns on a network can be generated using a variety of models.

Maintained by Adrian Baddeley. Last updated 2 months ago.

density-estimation heat-equation kernel-density-estimation network-analysis point-processes spatial-data-analysis statistical-analysis statistical-inference statistical-models

5.8 match 6 stars 9.64 score 35 scripts 43 dependents

scheike

timereg:Flexible Regression Models for Survival Data

Programs for Martinussen and Scheike (2006), `Dynamic Regression Models for Survival Data', Springer Verlag. Plus more recent developments. Additive survival model, semiparametric proportional odds model, fast cumulative residuals, excess risk models and more. Flexible competing risks regression including GOF-tests. Two-stage frailty modelling. PLS for the additive risk model. Lasso in the 'ahaz' package.

Maintained by Thomas Scheike. Last updated 6 months ago.

openblas

5.3 match 31 stars 10.42 score 289 scripts 44 dependents

ropensci

targets:Dynamic Function-Oriented 'Make'-Like Declarative Pipelines

Pipeline tools coordinate the pieces of computationally demanding analysis projects. The 'targets' package is a 'Make'-like pipeline tool for statistics and data science in R. The package skips costly runtime for tasks that are already up to date, orchestrates the necessary computation with implicit parallel computing, and abstracts files as R objects. If all the current output matches the current upstream code and data, then the whole pipeline is up to date, and the results are more trustworthy than otherwise. The methodology in this package borrows from GNU 'Make' (2015, ISBN:978-9881443519) and 'drake' (2018, <doi:10.21105/joss.00550>).

Maintained by William Michael Landau. Last updated 9 hours ago.

data-science high-performance-computing make peer-reviewed pipeline r-targetopia reproducibility reproducible-research targets workflow

3.6 match 975 stars 15.18 score 4.6k scripts 22 dependents

ropensci

citecorp:Client for the Open Citations Corpus

Client for the Open Citations Corpus (<http://opencitations.net/>). Includes a set of functions for getting one identifier type from another, as well as getting references and citations for a given identifier.

Maintained by David Selby. Last updated 1 months ago.

doi metadata citation opencitations bibtex citations pmcid pmid sparql

11.4 match 11 stars 4.81 score 13 scripts

ropensci

rdhs:API Client and Dataset Management for the Demographic and Health Survey (DHS) Data

Provides a client for (1) querying the DHS API for survey indicators and metadata (<https://api.dhsprogram.com/#/index.html>), (2) identifying surveys and datasets for analysis, (3) downloading survey datasets from the DHS website, (4) loading datasets and associate metadata into R, and (5) extracting variables and combining datasets for pooled analysis.

Maintained by OJ Watson. Last updated 19 days ago.

dataset dhs dhs-api extract peer-reviewed survey-data

5.4 match 35 stars 10.07 score 286 scripts 3 dependents

mrc-ide

epireview:Tools to update and summarise the latest pathogen data from the Pathogen Epidemiology Review Group (PERG)

Contains the latest open access pathogen data from the Pathogen Epidemiology Review Group (PERG). Tools are available to update pathogen databases with new peer-reviewed data as it becomes available, and to summarise the latest data using tables and figures.

Maintained by Sangeeta Bhatia. Last updated 4 days ago.

8.1 match 30 stars 6.76 score 6 scripts

swarchal

platetools:Tools and Plots for Multi-Well Plates

Collection of functions for working with multi-well microtitre plates, mainly 96, 384 and 1536 well plates.

Maintained by Scott Warchal. Last updated 1 years ago.

biology ggplot2 lab

8.8 match 54 stars 6.20 score 146 scripts

bioc

ORFhunteR:Predict open reading frames in nucleotide sequences

The ORFhunteR package is a R and C++ library for an automatic determination and annotation of open reading frames (ORF) in a large set of RNA molecules. It efficiently implements the machine learning model based on vectorization of nucleotide sequences and the random forest classification algorithm. The ORFhunteR package consists of a set of functions written in the R language in conjunction with C++. The efficiency of the package was confirmed by the examples of the analysis of RNA molecules from the NCBI RefSeq and Ensembl databases. The package can be used in basic and applied biomedical research related to the study of the transcriptome of normal as well as altered (for example, cancer) human cells.

Maintained by Vasily V. Grinev. Last updated 5 months ago.

technology statisticalmethod sequencing rnaseq classification featureextraction cpp

12.0 match 1 stars 4.48 score

bioc

wavClusteR:Sensitive and highly resolved identification of RNA-protein interaction sites in PAR-CLIP data

The package provides an integrated pipeline for the analysis of PAR-CLIP data. PAR-CLIP-induced transitions are first discriminated from sequencing errors, SNPs and additional non-experimental sources by a non- parametric mixture model. The protein binding sites (clusters) are then resolved at high resolution and cluster statistics are estimated using a rigorous Bayesian framework. Post-processing of the results, data export for UCSC genome browser visualization and motif search analysis are provided. In addition, the package allows to integrate RNA-Seq data to estimate the False Discovery Rate of cluster detection. Key functions support parallel multicore computing. Note: while wavClusteR was designed for PAR-CLIP data analysis, it can be applied to the analysis of other NGS data obtained from experimental procedures that induce nucleotide substitutions (e.g. BisSeq).

Maintained by Federico Comoglio. Last updated 5 months ago.

immunooncology sequencing technology ripseq rnaseq bayesian

11.7 match 4.60 score 3 scripts

bioc

gemma.R:A wrapper for Gemma's Restful API to access curated gene expression data and differential expression analyses

Low- and high-level wrappers for Gemma's RESTful API. They enable access to curated expression and differential expression data from over 10,000 published studies. Gemma is a web site, database and a set of tools for the meta-analysis, re-use and sharing of genomics data, currently primarily targeted at the analysis of gene expression profiles.

Maintained by Ogan Mancarci. Last updated 4 months ago.

software dataimport microarray singlecell thirdpartyclient differentialexpression geneexpression bayesian annotation experimentaldesign normalization batcheffect preprocessing bioinformatics gemma genomics transcriptomics

7.0 match 10 stars 7.57 score 26 scripts

bergsmat

nonmemica:Create and Evaluate NONMEM Models in a Project Context

Systematically creates and modifies NONMEM(R) control streams. Harvests NONMEM output, builds run logs, creates derivative data, generates diagnostics. NONMEM (ICON Development Solutions <https://www.iconplc.com/>) is software for nonlinear mixed effects modeling. See 'package?nonmemica'.

Maintained by Tim Bergsma. Last updated 2 months ago.

11.6 match 4 stars 4.58 score 45 scripts

alarm-redist

redist:Simulation Methods for Legislative Redistricting

Enables researchers to sample redistricting plans from a pre-specified target distribution using Sequential Monte Carlo and Markov Chain Monte Carlo algorithms. The package allows for the implementation of various constraints in the redistricting process such as geographic compactness and population parity requirements. Tools for analysis such as computation of various summary statistics and plotting functionality are also included. The package implements the SMC algorithm of McCartan and Imai (2023) <doi:10.1214/23-AOAS1763>, the enumeration algorithm of Fifield, Imai, Kawahara, and Kenny (2020) <doi:10.1080/2330443X.2020.1791773>, the Flip MCMC algorithm of Fifield, Higgins, Imai and Tarr (2020) <doi:10.1080/10618600.2020.1739532>, the Merge-split/Recombination algorithms of Carter et al. (2019) <arXiv:1911.01503> and DeFord et al. (2021) <doi:10.1162/99608f92.eb30390f>, and the Short-burst optimization algorithm of Cannon et al. (2020) <arXiv:2011.02288>.

Maintained by Christopher T. Kenny. Last updated 2 months ago.

geospatial gerrymandering redistricting sampling openblas cpp openmp

5.8 match 68 stars 9.17 score 259 scripts

bupaverse

bupaR:Business Process Analysis in R

Comprehensive Business Process Analysis toolkit. Creates S3-class for event log objects, and related handler functions. Imports related packages for filtering event data, computation of descriptive statistics, handling of 'Petri Net' objects and visualization of process maps. See also packages 'edeaR','processmapR', 'eventdataR' and 'processmonitR'.

Maintained by Gert Janssenswillen. Last updated 2 years ago.

5.8 match 55 stars 9.07 score 389 scripts 11 dependents

cran

mgcv:Mixed GAM Computation Vehicle with Automatic Smoothness Estimation

Generalized additive (mixed) models, some of their extensions and other generalized ridge regression with multiple smoothing parameter estimation by (Restricted) Marginal Likelihood, Generalized Cross Validation and similar, or using iterated nested Laplace approximation for fully Bayesian inference. See Wood (2017) <doi:10.1201/9781315370279> for an overview. Includes a gam() function, a wide variety of smoothers, 'JAGS' support and distributions beyond the exponential family.

Maintained by Simon Wood. Last updated 1 years ago.

openblas openmp

4.1 match 32 stars 12.71 score 17k scripts 7.8k dependents

bioc

scDblFinder:scDblFinder

The scDblFinder package gathers various methods for the detection and handling of doublets/multiplets in single-cell sequencing data (i.e. multiple cells captured within the same droplet or reaction volume). It includes methods formerly found in the scran package, the new fast and comprehensive scDblFinder method, and a reimplementation of the Amulet detection method for single-cell ATAC-seq.

Maintained by Pierre-Luc Germain. Last updated 2 months ago.

preprocessing singlecell rnaseq atacseq doublets single-cell

4.3 match 184 stars 12.34 score 888 scripts 1 dependents

bayesiandemography

poputils:Demographic Analysis and Data Manipulation

Perform tasks commonly encountered when preparing and analysing demographic data. Some functions are intended for end users, and others for developers. Includes functions for working with life tables.

Maintained by John Bryant. Last updated 6 months ago.

cpp

9.4 match 5.57 score 49 scripts 1 dependents

bioc

AUCell:AUCell: Analysis of 'gene set' activity in single-cell RNA-seq data (e.g. identify cells with specific gene signatures)

AUCell allows to identify cells with active gene sets (e.g. signatures, gene modules...) in single-cell RNA-seq data. AUCell uses the "Area Under the Curve" (AUC) to calculate whether a critical subset of the input gene set is enriched within the expressed genes for each cell. The distribution of AUC scores across all the cells allows exploring the relative expression of the signature. Since the scoring method is ranking-based, AUCell is independent of the gene expression units and the normalization procedure. In addition, since the cells are evaluated individually, it can easily be applied to bigger datasets, subsetting the expression matrix if needed.

Maintained by Gert Hulselmans. Last updated 5 months ago.

singlecell genesetenrichment transcriptomics transcription geneexpression workflowstep normalization

6.1 match 8.59 score 860 scripts 4 dependents

bioc

phyloseq:Handling and analysis of high-throughput microbiome census data

phyloseq provides a set of classes and tools to facilitate the import, storage, analysis, and graphical display of microbiome census data.

Maintained by Paul J. McMurdie. Last updated 5 months ago.

immunooncology sequencing microbiome metagenomics clustering classification multiplecomparison geneticvariability

3.8 match 597 stars 13.90 score 8.4k scripts 37 dependents

bioc

maftools:Summarize, Analyze and Visualize MAF Files

Analyze and visualize Mutation Annotation Format (MAF) files from large scale sequencing studies. This package provides various functions to perform most commonly used analyses in cancer genomics and to create feature rich customizable visualzations with minimal effort.

Maintained by Anand Mayakonda. Last updated 5 months ago.

datarepresentation dnaseq visualization drivermutation variantannotation featureextraction classification somaticmutation sequencing functionalgenomics survival bioinformatics cancer-genome-atlas cancer-genomics genomics maf-files tcga curl bzip2 xz-utils zlib

3.6 match 459 stars 14.63 score 948 scripts 18 dependents

bioc

proActiv:Estimate Promoter Activity from RNA-Seq data

Most human genes have multiple promoters that control the expression of different isoforms. The use of these alternative promoters enables the regulation of isoform expression pre-transcriptionally. Alternative promoters have been found to be important in a wide number of cell types and diseases. proActiv is an R package that enables the analysis of promoters from RNA-seq data. proActiv uses aligned reads as input, and generates counts and normalized promoter activity estimates for each annotated promoter. In particular, proActiv accepts junction files from TopHat2 or STAR or BAM files as inputs. These estimates can then be used to identify which promoter is active, which promoter is inactive, and which promoters change their activity across conditions. proActiv also allows visualization of promoter activity across conditions.

Maintained by Joseph Lee. Last updated 5 months ago.

rnaseq geneexpression transcription alternativesplicing generegulation differentialsplicing functionalgenomics epigenetics transcriptomics preprocessing alternative-promoters genomics promoter-activity promoter-annotation rna-seq-data

7.8 match 51 stars 6.66 score 15 scripts

wincowgerdev

OpenSpecy:Analyze, Process, Identify, and Share Raman and (FT)IR Spectra

Raman and (FT)IR spectral analysis tool for plastic particles and other environmental samples (Cowger et al. 2021, <doi:10.1021/acs.analchem.1c00123>). With read_any(), Open Specy provides a single function for reading individual, batch, or map spectral data files like .asp, .csv, .jdx, .spc, .spa, .0, and .zip. process_spec() simplifies processing spectra, including smoothing, baseline correction, range restriction and flattening, intensity conversions, wavenumber alignment, and min-max normalization. Spectra can be identified in batch using an onboard reference library (Cowger et al. 2020, <doi:10.1177/0003702820929064>) using match_spec(). A Shiny app is available via run_app() or online at <https://openanalysis.org/openspecy/>.

Maintained by Win Cowger. Last updated 18 days ago.

6.8 match 29 stars 7.58 score 22 scripts

bioc

psichomics:Graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation

Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

Maintained by Nuno Saraiva-Agostinho. Last updated 5 months ago.

sequencing rnaseq alternativesplicing differentialsplicing transcription gui principalcomponent survival biomedicalinformatics transcriptomics immunooncology visualization multiplecomparison geneexpression differentialexpression alternative-splicing bioconductor data-analyses differential-gene-expression differential-splicing-analysis gene-expression gtex recount2 rna-seq-data splicing-quantification sra tcga vast-tools cpp

7.4 match 36 stars 6.95 score 31 scripts

r-spatial

gstat:Spatial and Spatio-Temporal Geostatistical Modelling, Prediction and Simulation

Variogram modelling; simple, ordinary and universal point or block (co)kriging; spatio-temporal kriging; sequential Gaussian or indicator (co)simulation; variogram and variogram map plotting utility functions; supports sf and stars.

Maintained by Edzer Pebesma. Last updated 11 days ago.

openblas

3.5 match 197 stars 14.78 score 4.8k scripts 57 dependents

edzer

intervals:Tools for Working with Points and Intervals

Tools for working with and comparing sets of points and intervals.

Maintained by Edzer Pebesma. Last updated 7 months ago.

cpp

5.4 match 11 stars 9.40 score 122 scripts 90 dependents

bioc

bioassayR:Cross-target analysis of small molecule bioactivity

bioassayR is a computational tool that enables simultaneous analysis of thousands of bioassay experiments performed over a diverse set of compounds and biological targets. Unique features include support for large-scale cross-target analyses of both public and custom bioassays, generation of high throughput screening fingerprints (HTSFPs), and an optional preloaded database that provides access to a substantial portion of publicly available bioactivity data.

Maintained by Thomas Girke. Last updated 5 months ago.

immunooncology microtitreplateassay cellbasedassays visualization infrastructure dataimport bioinformatics proteomics metabolomics

7.6 match 5 stars 6.70 score 46 scripts

cran

gprofiler2:Interface to the 'g:Profiler' Toolset

A toolset for functional enrichment analysis and visualization, gene/protein/SNP identifier conversion and mapping orthologous genes across species via 'g:Profiler' (<https://biit.cs.ut.ee/gprofiler/>). The main tools are: (1) 'g:GOSt' - functional enrichment analysis and visualization of gene lists; (2) 'g:Convert' - gene/protein/transcript identifier conversion across various namespaces; (3) 'g:Orth' - orthology search across species; (4) 'g:SNPense' - mapping SNP rs identifiers to chromosome positions, genes and variant effects. This package is an R interface corresponding to the 2019 update of 'g:Profiler' and provides access to 'g:Profiler' for versions 'e94_eg41_p11' and higher. See the package 'gProfileR' for accessing older versions from the 'g:Profiler' toolset.

Maintained by Liis Kolberg. Last updated 1 years ago.

6.4 match 4 stars 7.97 score 1.5k scripts 16 dependents

ssnn-airr

scoper:Spectral Clustering-Based Method for Identifying B Cell Clones

Provides a computational framework for identification of B cell clones from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. Three main functions are included (identicalClones, hierarchicalClones, and spectralClones) that perform clustering among sequences of BCRs/IGs (B cell receptors/immunoglobulins) which share the same V gene, J gene and junction length. Nouri N and Kleinstein SH (2018) <doi: 10.1093/bioinformatics/bty235>. Nouri N and Kleinstein SH (2019) <doi: 10.1101/788620>. Gupta NT, et al. (2017) <doi: 10.4049/jimmunol.1601850>.

Maintained by Susanna Marquez. Last updated 2 months ago.

cpp

9.3 match 5.43 score 89 scripts

bioc

ggtree:an R package for visualization of tree and annotation data

'ggtree' extends the 'ggplot2' plotting system which implemented the grammar of graphics. 'ggtree' is designed for visualization and annotation of phylogenetic trees and other tree-like structures with their annotation data.

Maintained by Guangchuang Yu. Last updated 5 months ago.

alignment annotation clustering dataimport multiplesequencealignment phylogenetics reproducibleresearch software visualization annotations ggplot2 phylogenetic-trees

3.0 match 864 stars 16.86 score 5.1k scripts 109 dependents

bioc

GeneNetworkBuilder:GeneNetworkBuilder: a bioconductor package for building regulatory network using ChIP-chip/ChIP-seq data and Gene Expression Data

Appliation for discovering direct or indirect targets of transcription factors using ChIP-chip or ChIP-seq, and microarray or RNA-seq gene expression data. Inputting a list of genes of potential targets of one TF from ChIP-chip or ChIP-seq, and the gene expression results, GeneNetworkBuilder generates a regulatory network of the TF.

Maintained by Jianhong Ou. Last updated 10 days ago.

sequencing microarray graphandnetwork cpp

13.4 match 3.77 score 17 scripts

bioc

r3Cseq:Analysis of Chromosome Conformation Capture and Next-generation Sequencing (3C-seq)

This package is used for the analysis of long-range chromatin interactions from 3C-seq assay.

Maintained by Supat Thongjuea. Last updated 5 months ago.

preprocessing sequencing

10.3 match 3 stars 4.85 score 17 scripts

paterijk

MCDA:Support for the Multicriteria Decision Aiding Process

Support for the analyst in a Multicriteria Decision Aiding (MCDA) process with algorithms, preference elicitation and data visualisation functions. Sébastien Bigaret, Richard Hodgett, Patrick Meyer, Tatyana Mironova, Alexandru Olteanu (2017) Supporting the multi-criteria decision aiding process : R and the MCDA package, Euro Journal On Decision Processes, Volume 5, Issue 1 - 4, pages 169 - 194 <doi:10.1007/s40070-017-0064-1>.

Maintained by Patrick Meyer. Last updated 2 years ago.

8.3 match 30 stars 6.04 score 182 scripts

bioc

limma:Linear Models for Microarray and Omics Data

Data analysis, linear models and differential expression for omics data.

Maintained by Gordon Smyth. Last updated 7 days ago.

exonarray geneexpression transcription alternativesplicing differentialexpression differentialsplicing genesetenrichment dataimport bayesian clustering regression timecourse microarray micrornaarray mrnamicroarray onechannel proprietaryplatforms twochannel sequencing rnaseq batcheffect multiplecomparison normalization preprocessing qualitycontrol biomedicalinformatics cellbiology cheminformatics epigenetics functionalgenomics genetics immunooncology metabolomics proteomics systemsbiology transcriptomics

3.6 match 13.81 score 16k scripts 585 dependents

ropensci

rdatacite:Client for the 'DataCite' API

Client for the web service methods provided by 'DataCite' (<https://www.datacite.org/>), including functions to interface with their 'RESTful' search API. The API is backed by 'Elasticsearch', allowing expressive queries, including faceting.

Maintained by Bianca Kramer. Last updated 2 years ago.

data scholarly dataset https api web-services api-wrapper datacite identifier metadata oai-pmh solr

10.0 match 25 stars 4.99 score 26 scripts

kkholst

lava:Latent Variable Models

A general implementation of Structural Equation Models with latent variables (MLE, 2SLS, and composite likelihood estimators) with both continuous, censored, and ordinal outcomes (Holst and Budtz-Joergensen (2013) <doi:10.1007/s00180-012-0344-y>). Mixture latent variable models and non-linear latent variable models (Holst and Budtz-Joergensen (2020) <doi:10.1093/biostatistics/kxy082>). The package also provides methods for graph exploration (d-separation, back-door criterion), simulation of general non-linear latent variable models, and estimation of influence functions for a broad range of statistical models.

Maintained by Klaus K. Holst. Last updated 2 months ago.

latent-variable-models simulation statistics structural-equation-models

3.9 match 33 stars 12.85 score 610 scripts 476 dependents

bioc

MSnbase:Base Functions and Classes for Mass Spectrometry and Proteomics

MSnbase provides infrastructure for manipulation, processing and visualisation of mass spectrometry and proteomics data, ranging from raw to quantitative and annotated data.

Maintained by Laurent Gatto. Last updated 4 days ago.

immunooncology infrastructure proteomics massspectrometry qualitycontrol dataimport bioconductor bioinformatics mass-spectrometry proteomics-data visualisation cpp

3.9 match 130 stars 12.81 score 772 scripts 36 dependents

bioc

genefu:Computation of Gene Expression-Based Signatures in Breast Cancer

This package contains functions implementing various tasks usually required by gene expression analysis, especially in breast cancer studies: gene mapping between different microarray platforms, identification of molecular subtypes, implementation of published gene signatures, gene selection, and survival analysis.

Maintained by Benjamin Haibe-Kains. Last updated 4 months ago.

differentialexpression geneexpression visualization clustering classification

6.7 match 7.42 score 193 scripts 3 dependents

mountainmath

cmhc:Access, Retrieve, and Work with CMHC Data

Wrapper around the Canadian Mortgage and Housing Corporation (CMHC) web interface. It enables programmatic and reproducible access to a wide variety of housing data from CMHC.

Maintained by Jens von Bergmann. Last updated 1 months ago.

6.8 match 20 stars 7.09 score 68 scripts

ropensci

EDIutils:An API Client for the Environmental Data Initiative Repository

A client for the Environmental Data Initiative repository REST API. The 'EDI' data repository <https://portal.edirepository.org/nis/home.jsp> is for publication and reuse of ecological data with emphasis on metadata accuracy and completeness. It is built upon the 'PASTA+' software stack <https://pastaplus-core.readthedocs.io/en/latest/index.html#> and was developed in collaboration with the US 'LTER' Network <https://lternet.edu/>. 'EDIutils' includes functions to search and access existing data, evaluate and upload new data, and assist other data management tasks common to repository users.

Maintained by Colin Smith. Last updated 1 years ago.

ecology eml-metadata open-access open-data research-data-management research-data-repository

7.4 match 10 stars 6.47 score 117 scripts

bioc

flowWorkspace:Infrastructure for representing and interacting with gated and ungated cytometry data sets.

This package is designed to facilitate comparison of automated gating methods against manual gating done in flowJo. This package allows you to import basic flowJo workspaces into BioConductor and replicate the gating from flowJo using the flowCore functionality. Gating hierarchies, groups of samples, compensation, and transformation are performed so that the output matches the flowJo analysis.

Maintained by Greg Finak. Last updated 11 days ago.

immunooncology flowcytometry dataimport preprocessing datarepresentation zlib openblas cpp

6.0 match 7.89 score 576 scripts 10 dependents

bioc

scQTLtools:An R package for single-cell eQTL analysis and visualization

This package specializes in analyzing and visualizing eQTL at the single-cell level. It can read gene expression matrices or Seurat data, or SingleCellExperiment object along with genotype data. It offers a function for cis-eQTL analysis to detect eQTL within a given range, and another function to fit models with three methods. Using this package, users can also generate single-cell level visualization result.

Maintained by Xiaofeng Wu. Last updated 2 months ago.

software geneexpression geneticvariability snp differentialexpression genomicvariation variantdetection genetics functionalgenomics systemsbiology regression singlecell normalization visualization rna-seq sc-eqtl

9.5 match 3 stars 4.95 score

bnaras

distcomp:Computations over Distributed Data without Aggregation

Implementing algorithms and fitting models when sites (possibly remote) share computation summaries rather than actual data over HTTP with a master R process (using 'opencpu', for example). A stratified Cox model and a singular value decomposition are provided. The former makes direct use of code from the R 'survival' package. (That is, the underlying Cox model code is derived from that in the R 'survival' package.) Sites may provide data via several means: CSV files, Redcap API, etc. An extensible design allows for new methods to be added in the future and includes facilities for local prototyping and testing. Web applications are provided (via 'shiny') for the implemented methods to help in designing and deploying the computations.

Maintained by Balasubramanian Narasimhan. Last updated 9 months ago.

8.9 match 9 stars 5.33 score 47 scripts

bioc

scran:Methods for Single-Cell RNA-Seq Data Analysis

Implements miscellaneous functions for interpretation of single-cell RNA-seq data. Methods are provided for assignment of cell cycle phase, detection of highly variable and significantly correlated genes, identification of marker genes, and other common tasks in routine single-cell analysis workflows.

Maintained by Aaron Lun. Last updated 5 months ago.

immunooncology normalization sequencing rnaseq software geneexpression transcriptomics singlecell clustering bioconductor-package human-cell-atlas single-cell-rna-seq openblas cpp

3.6 match 41 stars 13.14 score 7.6k scripts 36 dependents

ropensci

rotl:Interface to the 'Open Tree of Life' API

An interface to the 'Open Tree of Life' API to retrieve phylogenetic trees, information about studies used to assemble the synthetic tree, and utilities to match taxonomic names to 'Open Tree identifiers'. The 'Open Tree of Life' aims at assembling a comprehensive phylogenetic tree for all named species.

Maintained by Francois Michonneau. Last updated 2 years ago.

metadata ropensci phylogenetics independant-contrasts biodiversity peer-reviewed phylogeny taxonomy

3.9 match 40 stars 12.05 score 356 scripts 29 dependents

egeulgen

driveR:Prioritizing Cancer Driver Genes Using Genomics Data

Cancer genomes contain large numbers of somatic alterations but few genes drive tumor development. Identifying cancer driver genes is critical for precision oncology. Most of current approaches either identify driver genes based on mutational recurrence or using estimated scores predicting the functional consequences of mutations. 'driveR' is a tool for personalized or batch analysis of genomic data for driver gene prioritization by combining genomic information and prior biological knowledge. As features, 'driveR' uses coding impact metaprediction scores, non-coding impact scores, somatic copy number alteration scores, hotspot gene/double-hit gene condition, 'phenolyzer' gene scores and memberships to cancer-related KEGG pathways. It uses these features to estimate cancer-type-specific probability for each gene of being a cancer driver using the related task of a multi-task learning classification model. The method is described in detail in Ulgen E, Sezerman OU. 2021. driveR: driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. BMC Bioinformatics <doi:10.1186/s12859-021-04203-7>.

Maintained by Ege Ulgen. Last updated 2 years ago.

cancer-driverness driver driver-gene-prioritization identify-driver-genes ranking-genes scoring

7.4 match 15 stars 6.29 score 260 scripts

statist7

sitar:Super Imposition by Translation and Rotation Growth Curve Analysis

Functions for fitting and plotting SITAR (Super Imposition by Translation And Rotation) growth curve models. SITAR is a shape-invariant model with a regression B-spline mean curve and subject-specific random effects on both the measurement and age scales. The model was first described by Lindstrom (1995) <doi:10.1002/sim.4780141807> and developed as the SITAR method by Cole et al (2010) <doi:10.1093/ije/dyq115>.

Maintained by Tim Cole. Last updated 2 months ago.

5.4 match 13 stars 8.69 score 58 scripts 3 dependents

bioc

Nebulosa:Single-Cell Data Visualisation Using Kernel Gene-Weighted Density Estimation

This package provides a enhanced visualization of single-cell data based on gene-weighted density estimation. Nebulosa recovers the signal from dropped-out features and allows the inspection of the joint expression from multiple features (e.g. genes). Seurat and SingleCellExperiment objects can be used within Nebulosa.

Maintained by Jose Alquicira-Hernandez. Last updated 5 months ago.

software geneexpression singlecell visualization dimensionreduction single-cell single-cell-analysis single-cell-multiomics single-cell-rna-seq

4.8 match 99 stars 9.66 score 494 scripts

hugaped

MBNMAdose:Dose-Response MBNMA Models

Fits Bayesian dose-response model-based network meta-analysis (MBNMA) that incorporate multiple doses within an agent by modelling different dose-response functions, as described by Mawdsley et al. (2016) <doi:10.1002/psp4.12091>. By modelling dose-response relationships this can connect networks of evidence that might otherwise be disconnected, and can improve precision on treatment estimates. Several common dose-response functions are provided; others may be added by the user. Various characteristics and assumptions can be flexibly added to the models, such as shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting at the treatment level.

Maintained by Hugo Pedder. Last updated 1 months ago.

jags cpp

7.0 match 10 stars 6.60 score

rrrlw

dragonking:Statistical Tools to Identify Dragon Kings

Statistical tests and test statistics to identify events in a dataset that are dragon kings (DKs). The statistical methods in this package were reviewed in Wheatley & Sornette (2015) <doi:10.2139/ssrn.2645709>.

Maintained by Raoul Wadhwa. Last updated 6 years ago.

15.4 match 2 stars 3.00 score 6 scripts

rwalkbout

walkboutr:Generate Walk Bouts from GPS and Accelerometry Data

Process GPS and accelerometry data to generate walk bouts. A walk bout is a period of activity with accelerometer movement matching the patterns of walking with corresponding GPS measurements that confirm travel. The inputs of the 'walkboutr' package are individual-level accelerometry and GPS data. The outputs of the model are walk bouts with corresponding times, duration, and summary statistics on the sample population, which collapse all personally identifying information. These bouts can be used to measure walking both as an outcome of a change to the built environment or as a predictor of health outcomes such as a cardioprotective behavior. Kang B, Moudon AV, Hurvitz PM, Saelens BE (2017) <doi:10.1016/j.trd.2017.09.026>.

Maintained by Lauren Blair Wilner. Last updated 1 years ago.

11.0 match 4.18 score 9 scripts

bioc

cTRAP:Identification of candidate causal perturbations from differential gene expression data

Compare differential gene expression results with those from known cellular perturbations (such as gene knock-down, overexpression or small molecules) derived from the Connectivity Map. Such analyses allow not only to infer the molecular causes of the observed difference in gene expression but also to identify small molecules that could drive or revert specific transcriptomic alterations.

Maintained by Nuno Saraiva-Agostinho. Last updated 5 months ago.

differentialexpression geneexpression rnaseq transcriptomics pathways immunooncology genesetenrichment bioconductor bioinformatics cmap gene-expression l1000

9.0 match 5 stars 5.08 score 16 scripts

jtextor

dagitty:Graphical Analysis of Structural Causal Models

A port of the web-based software 'DAGitty', available at <https://dagitty.net>, for analyzing structural causal models (also known as directed acyclic graphs or DAGs). This package computes covariate adjustment sets for estimating causal effects, enumerates instrumental variables, derives testable implications (d-separation and vanishing tetrads), generates equivalent models, and includes a simple facility for data simulation.

Maintained by Johannes Textor. Last updated 3 months ago.

3.6 match 302 stars 12.83 score 1.7k scripts 11 dependents

ramiromagno

gwasrapidd:'REST' 'API' Client for the 'NHGRI'-'EBI' 'GWAS' Catalog

'GWAS' R 'API' Data Download. This package provides easy access to the 'NHGRI'-'EBI' 'GWAS' Catalog data by accessing the 'REST' 'API' <https://www.ebi.ac.uk/gwas/rest/docs/api/>.

Maintained by Ramiro Magno. Last updated 1 years ago.

thirdpartyclient biomedicalinformatics genomewideassociation snp association-studies gwas-catalog human rest-client trait trait-ontology

5.6 match 95 stars 8.10 score 49 scripts 1 dependents

bioc

ChIPpeakAnno:Batch annotation of the peaks identified from either ChIP-seq, ChIP-chip experiments, or any experiments that result in large number of genomic interval data

The package encompasses a range of functions for identifying the closest gene, exon, miRNA, or custom features—such as highly conserved elements and user-supplied transcription factor binding sites. Additionally, users can retrieve sequences around the peaks and obtain enriched Gene Ontology (GO) or Pathway terms. In version 2.0.5 and beyond, new functionalities have been introduced. These include features for identifying peaks associated with bi-directional promoters along with summary statistics (peaksNearBDP), summarizing motif occurrences in peaks (summarizePatternInPeaks), and associating additional identifiers with annotated peaks or enrichedGO (addGeneIDs). The package integrates with various other packages such as biomaRt, IRanges, Biostrings, BSgenome, GO.db, multtest, and stat to enhance its analytical capabilities.

Maintained by Jianhong Ou. Last updated 2 months ago.

annotation chipseq chipchip

5.2 match 8.75 score 584 scripts 6 dependents

bioc

betaHMM:A Hidden Markov Model Approach for Identifying Differentially Methylated Sites and Regions for Beta-Valued DNA Methylation Data

A novel approach utilizing a homogeneous hidden Markov model. And effectively model untransformed beta values. To identify DMCs while considering the spatial. Correlation of the adjacent CpG sites.

Maintained by Koyel Majumdar. Last updated 3 months ago.

dnamethylation differentialmethylation immunooncology biomedicalinformatics methylationarray software multiplecomparison sequencing spatial coverage genetarget hiddenmarkovmodel microarray

10.9 match 4.18 score

sfilges

umiAnalyzer:Tools for Analyzing Sequencing Data with Unique Molecular Identifiers

Tools for analyzing sequencing data containing unique molecular identifiers generated by 'UMIErrorCorrect' (<https://github.com/stahlberggroup/umierrorcorrect>).

Maintained by Stefan Filges. Last updated 3 years ago.

targeted-sequencing unique-molecular-identifiers variant-analysis

10.1 match 4.46 score 58 scripts

bioc

BrowserViz:BrowserViz: interactive R/browser graphics using websockets and JSON

Interactvive graphics in a web browser from R, using websockets and JSON.

Maintained by Arkadiusz Gladki. Last updated 5 months ago.

visualization thirdpartyclient

7.0 match 2 stars 6.28 score 20 scripts 2 dependents

adamlilith

fasterRaster:Faster Raster and Spatial Vector Processing Using 'GRASS GIS'

Processing of large-in-memory/large-on disk rasters and spatial vectors using 'GRASS GIS' <https://grass.osgeo.org/>. Most functions in the 'terra' package are recreated. Processing of medium-sized and smaller spatial objects will nearly always be faster using 'terra' or 'sf', but for large-in-memory/large-on-disk objects, 'fasterRaster' may be faster. To use most of the functions, you must have the stand-alone version (not the 'OSGeoW4' installer version) of 'GRASS GIS' 8.0 or higher.

Maintained by Adam B. Smith. Last updated 20 days ago.

aspect distance fragmentation fragmentation-indices gis grass grass-gis raster raster-projection rasterize slope topography vectorization

5.6 match 58 stars 7.69 score 8 scripts

frbcesab

forcis:An R Client to Access the FORCIS Database

Provides an interface to the FORCIS database (<https://zenodo.org/doi/10.5281/zenodo.7390791>) on global foraminifera distribution. This package allows to download and to handle FORCIS data. It is part of the FRB-CESAB working group FORCIS. <https://www.fondationbiodiversite.fr/en/the-frb-in-action/programs-and-projects/le-cesab/forcis/>.

Maintained by Nicolas Casajus. Last updated 13 days ago.

7.5 match 4 stars 5.76 score 5 scripts

bioc

CAGEfightR:Analysis of Cap Analysis of Gene Expression (CAGE) data using Bioconductor

CAGE is a widely used high throughput assay for measuring transcription start site (TSS) activity. CAGEfightR is an R/Bioconductor package for performing a wide range of common data analysis tasks for CAGE and 5'-end data in general. Core functionality includes: import of CAGE TSSs (CTSSs), tag (or unidirectional) clustering for TSS identification, bidirectional clustering for enhancer identification, annotation with transcript and gene models, correlation of TSS and enhancer expression, calculation of TSS shapes, quantification of CAGE expression as expression matrices and genome brower visualization.

Maintained by Malte Thodberg. Last updated 5 months ago.

software transcription coverage geneexpression generegulation peakdetection dataimport datarepresentation transcriptomics sequencing annotation genomebrowsers normalization preprocessing visualization

5.8 match 8 stars 7.46 score 67 scripts 1 dependents

bioc

DEGseq:Identify Differentially Expressed Genes from RNA-seq data

DEGseq is an R package to identify differentially expressed genes from RNA-Seq data.

Maintained by Likun Wang. Last updated 5 months ago.

rnaseq preprocessing geneexpression differentialexpression immunooncology cpp

8.5 match 5.03 score 54 scripts

randrescastaneda

joyn:Tool for Diagnosis of Tables Joins and Complementary Join Features

Tool for diagnosing table joins. It combines the speed of `collapse` and `data.table`, the flexibility of `dplyr`, and the diagnosis and features of the `merge` command in `Stata`.

Maintained by R.Andres Castaneda. Last updated 3 months ago.

join merge

6.1 match 9 stars 7.00 score 31 scripts

bioc

OmaDB:R wrapper for the OMA REST API

A package for the orthology prediction data download from OMA database.

Maintained by Klara Kaleb. Last updated 5 months ago.

software comparativegenomics functionalgenomics genetics annotation go functionalprediction

6.8 match 2 stars 6.23 score 5 scripts

ropensci

pangaear:Client for the 'Pangaea' Database

Tools to interact with the 'Pangaea' Database (<https://www.pangaea.de>), including functions for searching for data, fetching 'datasets' by 'dataset' 'ID', and working with the 'Pangaea' 'OAI-PMH' service.

Maintained by Scott Chamberlain. Last updated 2 years ago.

pangaea environmental science earth science archive paleontology ecology chemistry atmosphere api-client data paleobiology scientific webservice-client

6.8 match 21 stars 6.27 score 29 scripts

bioc

cBioPortalData:Exposes and Makes Available Data from the cBioPortal Web Resources

The cBioPortalData R package accesses study datasets from the cBio Cancer Genomics Portal. It accesses the data either from the pre-packaged zip / tar files or from the API interface that was recently implemented by the cBioPortal Data Team. The package can provide data in either tabular format or with MultiAssayExperiment object that uses familiar Bioconductor data representations.

Maintained by Marcel Ramos. Last updated 11 days ago.

software infrastructure thirdpartyclient bioconductor-package nci-itcr u24ca289073

4.2 match 33 stars 10.15 score 147 scripts 4 dependents

ropensci

allodb:Tree Biomass Estimation at Extra-Tropical Forest Plots

Standardize and simplify the tree biomass estimation process across globally distributed extratropical forests.

Maintained by Erika Gonzalez-Akre. Last updated 11 days ago.

7.1 match 38 stars 5.94 score 38 scripts

bioc

RegionalST:Investigating regions of interest and performing regional cell type-specific analysis with spatial transcriptomics data

This package analyze spatial transcriptomics data through cross-regional cell type-specific analysis. It selects regions of interest (ROIs) and identifys cross-regional cell type-specific differential signals. The ROIs can be selected using automatic algorithm or through manual selection. It facilitates manual selection of ROIs using a shiny application.

Maintained by Ziyi Li. Last updated 3 months ago.

spatial transcriptomics reactome kegg

9.8 match 4.30 score 8 scripts

josiahparry

sfdep:Spatial Dependence for Simple Features

An interface to 'spdep' to integrate with 'sf' objects and the 'tidyverse'.

Maintained by Dexter Locke. Last updated 6 months ago.

r-spatial spatial

6.0 match 130 stars 7.01 score 130 scripts

bioc

RcisTarget:RcisTarget Identify transcription factor binding motifs enriched on a list of genes or genomic regions

RcisTarget identifies transcription factor binding motifs (TFBS) over-represented on a gene list. In a first step, RcisTarget selects DNA motifs that are significantly over-represented in the surroundings of the transcription start site (TSS) of the genes in the gene-set. This is achieved by using a database that contains genome-wide cross-species rankings for each motif. The motifs that are then annotated to TFs and those that have a high Normalized Enrichment Score (NES) are retained. Finally, for each motif and gene-set, RcisTarget predicts the candidate target genes (i.e. genes in the gene-set that are ranked above the leading edge).

Maintained by Gert Hulselmans. Last updated 5 months ago.

generegulation motifannotation transcriptomics transcription genesetenrichment genetarget

4.4 match 37 stars 9.47 score 191 scripts

bioc

BioNERO:Biological Network Reconstruction Omnibus

BioNERO aims to integrate all aspects of biological network inference in a single package, including data preprocessing, exploratory analyses, network inference, and analyses for biological interpretations. BioNERO can be used to infer gene coexpression networks (GCNs) and gene regulatory networks (GRNs) from gene expression data. Additionally, it can be used to explore topological properties of protein-protein interaction (PPI) networks. GCN inference relies on the popular WGCNA algorithm. GRN inference is based on the "wisdom of the crowds" principle, which consists in inferring GRNs with multiple algorithms (here, CLR, GENIE3 and ARACNE) and calculating the average rank for each interaction pair. As all steps of network analyses are included in this package, BioNERO makes users avoid having to learn the syntaxes of several packages and how to communicate between them. Finally, users can also identify consensus modules across independent expression sets and calculate intra and interspecies module preservation statistics between different networks.

Maintained by Fabricio Almeida-Silva. Last updated 5 months ago.

software geneexpression generegulation systemsbiology graphandnetwork preprocessing network networkinference

5.3 match 27 stars 7.78 score 50 scripts 1 dependents

bioc

epimutacions:Robust outlier identification for DNA methylation data

The package includes some statistical outlier detection methods for epimutations detection in DNA methylation data. The methods included in the package are MANOVA, Multivariate linear models, isolation forest, robust mahalanobis distance, quantile and beta. The methods compare a case sample with a suspected disease against a reference panel (composed of healthy individuals) to identify epimutations in the given case sample. It also contains functions to annotate and visualize the identified epimutations.

Maintained by Dolors Pelegri-Siso. Last updated 5 months ago.

dnamethylation biologicalquestion preprocessing statisticalmethod normalization cpp

9.8 match 4.23 score 28 scripts

thomasjemielita

StratifiedMedicine:Stratified Medicine

A toolkit for stratified medicine, subgroup identification, and precision medicine. Current tools include (1) filtering models (reduce covariate space), (2) patient-level estimate models (counterfactual patient-level quantities, such as the conditional average treatment effect), (3) subgroup identification models (find subsets of patients with similar treatment effects), and (4) treatment effect estimation and inference (for the overall population and discovered subgroups). These tools can be customized and are directly used in PRISM (patient response identifiers for stratified medicine; Jemielita and Mehrotra 2019 <arXiv:1912.03337>. This package is in beta and will be continually updated.

Maintained by Thomas Jemielita. Last updated 3 years ago.

8.7 match 2 stars 4.73 score 27 scripts

larmarange

broom.helpers:Helpers for Model Coefficients Tibbles

Provides suite of functions to work with regression model 'broom::tidy()' tibbles. The suite includes functions to group regression model terms by variable, insert reference and header rows for categorical variables, add variable labels, and more.

Maintained by Joseph Larmarange. Last updated 11 days ago.

3.6 match 22 stars 11.45 score 165 scripts 2 dependents

bioc

Category:Category Analysis

A collection of tools for performing category (gene set enrichment) analysis.

Maintained by Bioconductor Package Maintainer. Last updated 5 months ago.

annotation go pathways genesetenrichment

5.2 match 7.93 score 183 scripts 16 dependents

hugaped

MBNMAtime:Run Time-Course Model-Based Network Meta-Analysis (MBNMA) Models

Fits Bayesian time-course models for model-based network meta-analysis (MBNMA) that allows inclusion of multiple time-points from studies. Repeated measures over time are accounted for within studies by applying different time-course functions, following the method of Pedder et al. (2019) <doi:10.1002/jrsm.1351>. The method allows synthesis of studies with multiple follow-up measurements that can account for time-course for a single or multiple treatment comparisons. Several general time-course functions are provided; others may be added by the user. Various characteristics can be flexibly added to the models, such as correlation between time points and shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting.

Maintained by Hugo Pedder. Last updated 1 months ago.

jags cpp

6.7 match 7 stars 6.10 score

bioc

MetMashR:Metabolite Mashing with R

A package to merge, filter sort, organise and otherwise mash together metabolite annotation tables. Metabolite annotations can be imported from multiple sources (software) and combined using workflow steps based on S4 class templates derived from the `struct` package. Other modular workflow steps such as filtering, merging, splitting, normalisation and rest-api queries are included.

Maintained by Gavin Rhys Lloyd. Last updated 5 months ago.

workflowstep metabolomics kegg

7.0 match 2 stars 5.81 score 5 scripts

opatp

GTFSwizard:Exploring and Manipulating 'GTFS' Files

Exploring, analyzing, and manipulating General Transit Feed Specification (GTFS) files, which represent public transportation schedules and geographic data. The package allows users to filter data by routes, trips, stops, and time, generate spatial visualizations, and perform detailed analyses of transit networks, including headway, dwell times, and route frequencies. Designed for transit planners, researchers, and data analysts, 'GTFSwizard' integrates functionalities from popular packages to enable efficient GTFS data manipulation and visualization.

Maintained by Nelson de O. Quesado Filho. Last updated 2 months ago.

gtfs transit

9.2 match 1 stars 4.41 score

bioc

gDRcore:Processing functions and interface to process and analyze drug dose-response data

This package contains core functions to process and analyze drug response data. The package provides tools for normalizing, averaging, and calculation of gDR metrics data. All core functions are wrapped into the pipeline function allowing analyzing the data in a straightforward way.

Maintained by Arkadiusz Gladki. Last updated 6 days ago.

software shinyapps cpp

5.6 match 2 stars 7.25 score 4 scripts 1 dependents

bioc

CatsCradle:This package provides methods for analysing spatial transcriptomics data and for discovering gene clusters

This package addresses two broad areas. It allows for in-depth analysis of spatial transcriptomic data by identifying tissue neighbourhoods. These are contiguous regions of tissue surrounding individual cells. 'CatsCradle' allows for the categorisation of neighbourhoods by the cell types contained in them and the genes expressed in them. In particular, it produces Seurat objects whose individual elements are neighbourhoods rather than cells. In addition, it enables the categorisation and annotation of genes by producing Seurat objects whose elements are genes.

Maintained by Michael Shapiro. Last updated 1 months ago.

biologicalquestion statisticalmethod geneexpression singlecell transcriptomics spatial

6.2 match 3 stars 6.50 score

bioc

matter:Out-of-core statistical computing and signal processing

Toolbox for larger-than-memory scientific computing and visualization, providing efficient out-of-core data structures using files or shared memory, for dense and sparse vectors, matrices, and arrays, with applications to nonuniformly sampled signals and images.

Maintained by Kylie A. Bemis. Last updated 3 months ago.

infrastructure datarepresentation dataimport dimensionreduction preprocessing cpp

4.3 match 57 stars 9.52 score 64 scripts 2 dependents

bioc

roar:Identify differential APA usage from RNA-seq alignments

Identify preferential usage of APA sites, comparing two biological conditions, starting from known alternative sites and alignments obtained from standard RNA-seq experiments.

Maintained by Elena Grassi. Last updated 5 months ago.

sequencing highthroughputsequencing rnaseq transcription

8.0 match 4 stars 5.05 score 14 scripts

heardacat

Ramble:Parser Combinator for R

Parser generator for R using combinatory parsers. It is inspired by combinatory parsers developed in Haskell.

Maintained by Chapman Siu. Last updated 8 years ago.

combinatory-parsers parser-combinators parsing

6.8 match 22 stars 5.93 score 39 scripts

ropensci

stplanr:Sustainable Transport Planning

Tools for transport planning with an emphasis on spatial transport data and non-motorized modes. The package was originally developed to support the 'Propensity to Cycle Tool', a publicly available strategic cycle network planning tool (Lovelace et al. 2017) <doi:10.5198/jtlu.2016.862>, but has since been extended to support public transport routing and accessibility analysis (Moreno-Monroy et al. 2017) <doi:10.1016/j.jtrangeo.2017.08.012> and routing with locally hosted routing engines such as 'OSRM' (Lowans et al. 2023) <doi:10.1016/j.enconman.2023.117337>. The main functions are for creating and manipulating geographic "desire lines" from origin-destination (OD) data (building on the 'od' package); calculating routes on the transport network locally and via interfaces to routing services such as <https://cyclestreets.net/> (Desjardins et al. 2021) <doi:10.1007/s11116-021-10197-1>; and calculating route segment attributes such as bearing. The package implements the 'travel flow aggregration' method described in Morgan and Lovelace (2020) <doi:10.1177/2399808320942779> and the 'OD jittering' method described in Lovelace et al. (2022) <doi:10.32866/001c.33873>. Further information on the package's aim and scope can be found in the vignettes and in a paper in the R Journal (Lovelace and Ellison 2018) <doi:10.32614/RJ-2018-053>, and in a paper outlining the landscape of open source software for geographic methods in transport planning (Lovelace, 2021) <doi:10.1007/s10109-020-00342-2>.

Maintained by Robin Lovelace. Last updated 7 months ago.

cycle cycling desire-lines origin-destination peer-reviewed pubic-transport route-network routes routing spatial transport transport-planning transportation walking

3.3 match 427 stars 12.31 score 684 scripts 3 dependents

bioc

MoonlightR:Identify oncogenes and tumor suppressor genes from omics data

Motivation: The understanding of cancer mechanism requires the identification of genes playing a role in the development of the pathology and the characterization of their role (notably oncogenes and tumor suppressors). Results: We present an R/bioconductor package called MoonlightR which returns a list of candidate driver genes for specific cancer types on the basis of TCGA expression data. The method first infers gene regulatory networks and then carries out a functional enrichment analysis (FEA) (implementing an upstream regulator analysis, URA) to score the importance of well-known biological processes with respect to the studied cancer type. Eventually, by means of random forests, MoonlightR predicts two specific roles for the candidate driver genes: i) tumor suppressor genes (TSGs) and ii) oncogenes (OCGs). As a consequence, this methodology does not only identify genes playing a dual role (e.g. TSG in one cancer type and OCG in another) but also helps in elucidating the biological processes underlying their specific roles. In particular, MoonlightR can be used to discover OCGs and TSGs in the same cancer type. This may help in answering the question whether some genes change role between early stages (I, II) and late stages (III, IV) in breast cancer. In the future, this analysis could be useful to determine the causes of different resistances to chemotherapeutic treatments.

Maintained by Matteo Tiberti. Last updated 5 months ago.

dnamethylation differentialmethylation generegulation geneexpression methylationarray differentialexpression pathways network survival genesetenrichment networkenrichment

6.1 match 17 stars 6.57 score

bioc

bioCancer:Interactive Multi-Omics Cancers Data Visualization and Analysis

This package is a Shiny App to visualize and analyse interactively Multi-Assays of Cancer Genomic Data.

Maintained by Karim Mezhoud. Last updated 5 months ago.

gui datarepresentation network multiplecomparison pathways reactome visualization geneexpression genetarget analysis biocancer-interface cancer cancer-studies rmarkdown

6.7 match 20 stars 5.95 score 7 scripts

bioc

BioTIP:BioTIP: An R package for characterization of Biological Tipping-Point

Adopting tipping-point theory to transcriptome profiles to unravel disease regulatory trajectory.

Maintained by Yuxi (Jennifer) Sun. Last updated 5 months ago.

sequencing rnaseq geneexpression transcription software

5.8 match 18 stars 6.84 score 37 scripts

functionaldata

fdapace:Functional Data Analysis and Empirical Dynamics

A versatile package that provides implementation of various methods of Functional Data Analysis (FDA) and Empirical Dynamics. The core of this package is Functional Principal Component Analysis (FPCA), a key technique for functional data analysis, for sparsely or densely sampled random trajectories and time courses, via the Principal Analysis by Conditional Estimation (PACE) algorithm. This core algorithm yields covariance and mean functions, eigenfunctions and principal component (scores), for both functional data and derivatives, for both dense (functional) and sparse (longitudinal) sampling designs. For sparse designs, it provides fitted continuous trajectories with confidence bands, even for subjects with very few longitudinal observations. PACE is a viable and flexible alternative to random effects modeling of longitudinal data. There is also a Matlab version (PACE) that contains some methods not available on fdapace and vice versa. Updates to fdapace were supported by grants from NIH Echo and NSF DMS-1712864 and DMS-2014626. Please cite our package if you use it (You may run the command citation("fdapace") to get the citation format and bibtex entry). References: Wang, J.L., Chiou, J., Müller, H.G. (2016) <doi:10.1146/annurev-statistics-041715-033624>; Chen, K., Zhang, X., Petersen, A., Müller, H.G. (2017) <doi:10.1007/s12561-015-9137-5>.

Maintained by Yidong Zhou. Last updated 9 months ago.

cpp

3.4 match 31 stars 11.46 score 474 scripts 25 dependents

bioc

fobitools:Tools for Manipulating the FOBI Ontology

A set of tools for interacting with the Food-Biomarker Ontology (FOBI). A collection of basic manipulation tools for biological significance analysis, graphs, and text mining strategies for annotating nutritional data.

Maintained by Pol Castellano-Escuder. Last updated 4 months ago.

massspectrometry metabolomics software visualization biomedicalinformatics graphandnetwork annotation cheminformatics pathways genesetenrichment biological-intrerpretation biological-knowledge biological-significance-analysis enrichment-analysis food-biomarker-ontology knowledge-graph nutrition obofoundry ontology text-mining

7.8 match 1 stars 5.08 score 5 scripts

jknowles

merTools:Tools for Analyzing Mixed Effect Regression Models

Provides methods for extracting results from mixed-effect model objects fit with the 'lme4' package. Allows construction of prediction intervals efficiently from large scale linear and generalized linear mixed-effects models. This method draws from the simulation framework used in the Gelman and Hill (2007) textbook: Data Analysis Using Regression and Multilevel/Hierarchical Models.

Maintained by Jared E. Knowles. Last updated 1 years ago.

3.8 match 105 stars 10.49 score 768 scripts

predictiveecology

SpaDES.tools:Additional Tools for Developing Spatially Explicit Discrete Event Simulation (SpaDES) Models

Provides GIS and map utilities, plus additional modeling tools for developing cellular automata, dynamic raster models, and agent based models in 'SpaDES'. Included are various methods for spatial spreading, spatial agents, GIS operations, random map generation, and others. See '?SpaDES.tools' for an categorized overview of these additional tools. The suggested package 'NLMR' can be installed from the following repository: (<https://PredictiveEcology.r-universe.dev>).

Maintained by Alex M Chubaty. Last updated 4 months ago.

cpp

5.2 match 4 stars 7.55 score 52 scripts 6 dependents

tbates

umx:Structural Equation Modeling and Twin Modeling in R

Quickly create, run, and report structural equation models, and twin models. See '?umx' for help, and umx_open_CRAN_page("umx") for NEWS. Timothy C. Bates, Michael C. Neale, Hermine H. Maes, (2019). umx: A library for Structural Equation and Twin Modelling in R. Twin Research and Human Genetics, 22, 27-41. <doi:10.1017/thg.2019.2>.

Maintained by Timothy C. Bates. Last updated 3 days ago.

behavior-genetics genetics openmx psychology sem statistics structural-equation-modeling tutorials twin-models umx

4.1 match 44 stars 9.45 score 472 scripts

bioc

InPAS:Identify Novel Alternative PolyAdenylation Sites (PAS) from RNA-seq data

Alternative polyadenylation (APA) is one of the important post- transcriptional regulation mechanisms which occurs in most human genes. InPAS facilitates the discovery of novel APA sites and the differential usage of APA sites from RNA-Seq data. It leverages cleanUpdTSeq to fine tune identified APA sites by removing false sites.

Maintained by Jianhong Ou. Last updated 2 months ago.

alternative polyadenylation differential polyadenylation site usage rna-seq gene regulation transcription

9.0 match 4.30 score 1 scripts

erichare

bulletr:Algorithms for Matching Bullet Lands

Analyze bullet lands using nonparametric methods. We provide a reading routine for x3p files (see <http://www.openfmc.org> for more information) and a host of analysis functions designed to assess the probability that two bullets were fired from the same gun barrel.

Maintained by Eric Hare. Last updated 7 years ago.

10.4 match 3.72 score 52 scripts

r-dbi

RMySQL:Database Interface and 'MySQL' Driver for R

Legacy 'DBI' interface to 'MySQL' / 'MariaDB' based on old code ported from S-PLUS. A modern 'MySQL' client written in 'C++' is available from the 'RMariaDB' package.

Maintained by Jeroen Ooms. Last updated 1 months ago.

database mysql

2.8 match 209 stars 13.68 score 3.7k scripts 15 dependents

bioc

M3Drop:Michaelis-Menten Modelling of Dropouts in single-cell RNASeq

This package fits a model to the pattern of dropouts in single-cell RNASeq data. This model is used as a null to identify significantly variable (i.e. differentially expressed) genes for use in downstream analysis, such as clustering cells. Also includes an method for calculating exact Pearson residuals in UMI-tagged data using a library-size aware negative binomial model.

Maintained by Tallulah Andrews. Last updated 5 months ago.

rnaseq sequencing transcriptomics geneexpression software differentialexpression dimensionreduction featureextraction human-cell-atlas rna-seq single-cell single-cell-rna-seq

4.4 match 29 stars 8.71 score 119 scripts 2 dependents