R-universe search: exports:vip

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bioc

mixOmics:Omics Data Integration Project

Multivariate methods are well suited to large omics data sets where the number of variables (e.g. genes, proteins, metabolites) is much larger than the number of samples (patients, cells, mice). They have the appealing properties of reducing the dimension of the data by using instrumental variables (components), which are defined as combinations of all variables. Those components are then used to produce useful graphical outputs that enable better understanding of the relationships and correlation structures between the different data sets that are integrated. mixOmics offers a wide range of multivariate methods for the exploration and integration of biological datasets with a particular focus on variable selection. The package proposes several sparse multivariate models we have developed to identify the key variables that are highly correlated, and/or explain the biological outcome of interest. The data that can be analysed with mixOmics may come from high throughput sequencing technologies, such as omics data (transcriptomics, metabolomics, proteomics, metagenomics etc) but also beyond the realm of omics (e.g. spectral imaging). The methods implemented in mixOmics can also handle missing values without having to delete entire rows with missing data. A non exhaustive list of methods include variants of generalised Canonical Correlation Analysis, sparse Partial Least Squares and sparse Discriminant Analysis. Recently we implemented integrative methods to combine multiple data sets: N-integration with variants of Generalised Canonical Correlation Analysis and P-integration with variants of multi-group Partial Least Squares.

Maintained by Eva Hamrud. Last updated 5 days ago.

immunooncology microarray sequencing metabolomics metagenomics proteomics geneprediction multiplecomparison classification regression bioconductor genomics genomics-data genomics-visualization multivariate-analysis multivariate-statistics omics r-pkg r-project

185 stars 13.75 score 1.3k scripts 22 dependents

koalaverse

vip:Variable Importance Plots

A general framework for constructing variable importance plots from various types of machine learning models in R. Aside from some standard model- specific variable importance measures, this package also provides model- agnostic approaches that can be applied to any supervised learning algorithm. These include 1) an efficient permutation-based variable importance measure, 2) variable importance based on Shapley values (Strumbelj and Kononenko, 2014) <doi:10.1007/s10115-013-0679-x>, and 3) the variance-based approach described in Greenwell et al. (2018) <arXiv:1805.04755>. A variance-based method for quantifying the relative strength of interaction effects is also included (see the previous reference for details).

Maintained by Brandon M. Greenwell. Last updated 2 years ago.

interaction-effect machine-learning partial-dependence-plot supervised-learning-algorithms variable-importance variable-importance-plots

187 stars 11.61 score 3.5k scripts 6 dependents

bioc

matter:Out-of-core statistical computing and signal processing

Toolbox for larger-than-memory scientific computing and visualization, providing efficient out-of-core data structures using files or shared memory, for dense and sparse vectors, matrices, and arrays, with applications to nonuniformly sampled signals and images.

Maintained by Kylie A. Bemis. Last updated 4 months ago.

infrastructure datarepresentation dataimport dimensionreduction preprocessing cpp

57 stars 9.52 score 64 scripts 2 dependents

guokai8

o2plsda:Multiomics Data Integration

Provides functions to do 'O2PLS-DA' analysis for multiple omics data integration. The algorithm came from "O2-PLS, a two-block (X±Y) latent variable regression (LVR) method with an integral OSC filter" which published by Johan Trygg and Svante Wold at 2003 <doi:10.1002/cem.775>. 'O2PLS' is a bidirectional multivariate regression method that aims to separate the covariance between two data sets (it was recently extended to multiple data sets) (Löfstedt and Trygg, 2011 <doi:10.1002/cem.1388>; Löfstedt et al., 2012 <doi:10.1016/j.aca.2013.06.026>) from the systematic sources of variance being specific for each data set separately.

Maintained by Kai Guo. Last updated 1 months ago.

integration multi-omics o2pls omics plsda openblas cpp openmp

7 stars 5.02 score 6 scripts

chemhouse-group

rchemo:Dimension Reduction, Regression and Discrimination for Chemometrics

Data exploration and prediction with focus on high dimensional data and chemometrics. The package was initially designed about partial least squares regression and discrimination models and variants, in particular locally weighted PLS models (LWPLS). Then, it has been expanded to many other methods for analyzing high dimensional data. The name 'rchemo' comes from the fact that the package is orientated to chemometrics, but most of the provided methods are fully generic to other domains. Functions such as transform(), predict(), coef() and summary() are available. Tuning the predictive models is facilitated by generic functions gridscore() (validation dataset) and gridcv() (cross-validation). Faster versions are also available for models based on latent variables (LVs) (gridscorelv() and gridcvlv()) and ridge regularization (gridscorelb() and gridcvlb()).

Maintained by Marion Brandolini-Bunlon. Last updated 7 months ago.

3 stars 3.52 score 11 scripts