Showing 4 of total 4 results (show query)
federicogiorgi
corto:Inference of Gene Regulatory Networks
We present 'corto' (Correlation Tool), a simple package to infer gene regulatory networks and visualize master regulators from gene expression data using DPI (Data Processing Inequality) and bootstrapping to recover edges. An initial step is performed to calculate all significant edges between a list of source nodes (centroids) and target genes. Then all triplets containing two centroids and one target are tested in a DPI step which removes edges. A bootstrapping process then calculates the robustness of the network, eventually re-adding edges previously removed by DPI. The algorithm has been optimized to run outside a computing cluster, using a fast correlation implementation. The package finally provides functions to calculate network enrichment analysis from RNA-Seq and ATAC-Seq signatures as described in the article by Giorgi lab (2020) <doi:10.1093/bioinformatics/btaa223>.
Maintained by Federico M. Giorgi. Last updated 2 years ago.
20 stars 6.25 score 59 scripts
crsuzh
ReplicationSuccess:Design and Analysis of Replication Studies
Provides utilities for the design and analysis of replication studies. Features both traditional methods based on statistical significance and more recent methods such as the sceptical p-value; Held L. (2020) <doi:10.1111/rssa.12493>, Held et al. (2022) <doi:10.1214/21-AOAS1502>, Micheloud et al. (2023) <doi:10.1111/stan.12312>. Also provides related methods including the harmonic mean chi-squared test; Held, L. (2020) <doi:10.1111/rssc.12410>, and intrinsic credibility; Held, L. (2019) <doi:10.1098/rsos.181534>. Contains datasets from five large-scale replication projects.
Maintained by Samuel Pawel. Last updated 5 months ago.
1 stars 4.72 score 35 scripts
bioc
vulcan:VirtUaL ChIP-Seq data Analysis using Networks
Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.
Maintained by Federico M. Giorgi. Last updated 5 months ago.
systemsbiologynetworkenrichmentgeneexpressionchipseq
3.38 score 12 scripts
manuelaott
pCalibrate:Bayesian Calibrations of p-Values
Implements transformations of p-values to the smallest possible Bayes factor within the specified class of alternative hypotheses, as described in Held & Ott (2018, <doi:10.1146/annurev-statistics-031017-100307>). Covers several common testing scenarios such as z-tests, t-tests, likelihood ratio tests and the F-test.
Maintained by Manuela Ott. Last updated 5 years ago.
1.36 score 23 scripts