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bioc

CATALYST:Cytometry dATa anALYSis Tools

CATALYST provides tools for preprocessing of and differential discovery in cytometry data such as FACS, CyTOF, and IMC. Preprocessing includes i) normalization using bead standards, ii) single-cell deconvolution, and iii) bead-based compensation. For differential discovery, the package provides a number of convenient functions for data processing (e.g., clustering, dimension reduction), as well as a suite of visualizations for exploratory data analysis and exploration of results from differential abundance (DA) and state (DS) analysis in order to identify differences in composition and expression profiles at the subpopulation-level, respectively.

Maintained by Helena L. Crowell. Last updated 4 months ago.

clusteringdataimportdifferentialexpressionexperimentaldesignflowcytometryimmunooncologymassspectrometrynormalizationpreprocessingsinglecellsoftwarestatisticalmethodvisualization

67 stars 10.99 score 362 scripts 2 dependents

bioc

clusterExperiment:Compare Clusterings for Single-Cell Sequencing

Provides functionality for running and comparing many different clusterings of single-cell sequencing data or other large mRNA Expression data sets.

Maintained by Elizabeth Purdom. Last updated 5 months ago.

clusteringrnaseqsequencingsoftwaresinglecellcpp

38 stars 9.62 score 192 scripts 1 dependents

bioc

COTAN:COexpression Tables ANalysis

Statistical and computational method to analyze the co-expression of gene pairs at single cell level. It provides the foundation for single-cell gene interactome analysis. The basic idea is studying the zero UMI counts' distribution instead of focusing on positive counts; this is done with a generalized contingency tables framework. COTAN can effectively assess the correlated or anti-correlated expression of gene pairs. It provides a numerical index related to the correlation and an approximate p-value for the associated independence test. COTAN can also evaluate whether single genes are differentially expressed, scoring them with a newly defined global differentiation index. Moreover, this approach provides ways to plot and cluster genes according to their co-expression pattern with other genes, effectively helping the study of gene interactions and becoming a new tool to identify cell-identity marker genes.

Maintained by Galfrè Silvia Giulia. Last updated 1 months ago.

systemsbiologytranscriptomicsgeneexpressionsinglecell

16 stars 7.85 score 96 scripts

cran

randomUniformForest:Random Uniform Forests for Classification, Regression and Unsupervised Learning

Ensemble model, for classification, regression and unsupervised learning, based on a forest of unpruned and randomized binary decision trees. Each tree is grown by sampling, with replacement, a set of variables at each node. Each cut-point is generated randomly, according to the continuous Uniform distribution. For each tree, data are either bootstrapped or subsampled. The unsupervised mode introduces clustering, dimension reduction and variable importance, using a three-layer engine. Random Uniform Forests are mainly aimed to lower correlation between trees (or trees residuals), to provide a deep analysis of variable importance and to allow native distributed and incremental learning.

Maintained by Saip Ciss. Last updated 3 years ago.

cpp

4 stars 2.90 score

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