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cran

nlme:Linear and Nonlinear Mixed Effects Models

Fit and compare Gaussian linear and nonlinear mixed-effects models.

Maintained by R Core Team. Last updated 2 months ago.

fortran

6 stars 9.77 score 8.8k dependents

bioc

pathwayPCA:Integrative Pathway Analysis with Modern PCA Methodology and Gene Selection

pathwayPCA is an integrative analysis tool that implements the principal component analysis (PCA) based pathway analysis approaches described in Chen et al. (2008), Chen et al. (2010), and Chen (2011). pathwayPCA allows users to: (1) Test pathway association with binary, continuous, or survival phenotypes. (2) Extract relevant genes in the pathways using the SuperPCA and AES-PCA approaches. (3) Compute principal components (PCs) based on the selected genes. These estimated latent variables represent pathway activities for individual subjects, which can then be used to perform integrative pathway analysis, such as multi-omics analysis. (4) Extract relevant genes that drive pathway significance as well as data corresponding to these relevant genes for additional in-depth analysis. (5) Perform analyses with enhanced computational efficiency with parallel computing and enhanced data safety with S4-class data objects. (6) Analyze studies with complex experimental designs, with multiple covariates, and with interaction effects, e.g., testing whether pathway association with clinical phenotype is different between male and female subjects. Citations: Chen et al. (2008) <https://doi.org/10.1093/bioinformatics/btn458>; Chen et al. (2010) <https://doi.org/10.1002/gepi.20532>; and Chen (2011) <https://doi.org/10.2202/1544-6115.1697>.

Maintained by Gabriel Odom. Last updated 5 months ago.

copynumbervariationdnamethylationgeneexpressionsnptranscriptiongenepredictiongenesetenrichmentgenesignalinggenetargetgenomewideassociationgenomicvariationcellbiologyepigeneticsfunctionalgenomicsgeneticslipidomicsmetabolomicsproteomicssystemsbiologytranscriptomicsclassificationdimensionreductionfeatureextractionprincipalcomponentregressionsurvivalmultiplecomparisonpathways

11 stars 7.74 score 42 scripts

norawuerz

saeTrafo:Transformations for Unit-Level Small Area Models

The aim of this package is to offer new methodology for unit-level small area models under transformations and limited population auxiliary information. In addition to this new methodology, the widely used nested error regression model without transformations (see "An Error-Components Model for Prediction of County Crop Areas Using Survey and Satellite Data" by Battese, Harter and Fuller (1988) <doi:10.1080/01621459.1988.10478561>) and its well-known uncertainty estimate (see "The estimation of the mean squared error of small-area estimators" by Prasad and Rao (1990) <doi:10.1080/01621459.1995.10476570>) are provided. In this package, the log transformation and the data-driven log-shift transformation are provided. If a transformation is selected, an appropriate method is chosen depending on the respective input of the population data: Individual population data (see "Empirical best prediction under a nested error model with log transformation" by Molina and Martín (2018) <doi:10.1214/17-aos1608>) but also aggregated population data (see "Estimating regional income indicators under transformations and access to limited population auxiliary information" by Würz, Schmid and Tzavidis <unpublished>) can be entered. Especially under limited data access, new methodologies are provided in saeTrafo. Several options are available to assess the used model and to judge, present and export its results. For a detailed description of the package and the methods used see the corresponding vignette.

Maintained by Nora Würz. Last updated 10 months ago.

1 stars 3.70 score