genpwr:Power Calculations Under Genetic Model Misspecification
Power and sample size calculations for genetic association studies allowing for misspecification of the model of genetic
susceptibility. "Hum Hered.
2019;84(6):256-271.<doi:10.1159/000508558>. Epub 2020 Jul 28."
Power and/or sample size can be calculated for logistic
(case/control study design) and linear (continuous phenotype)
regression models, using additive, dominant, recessive or
degree of freedom coding of the genetic covariate while
assuming a true dominant, recessive or additive genetic effect.
In addition, power and sample size calculations can be
performed for gene by environment interactions. These methods
are extensions of Gauderman (2002) <doi:10.1093/aje/155.5.478>
and Gauderman (2002) <doi:10.1002/sim.973> and are described
in: Moore CM, Jacobson S, Fingerlin TE. Power and Sample Size
Calculations for Genetic Association Studies in the Presence of
Genetic Model Misspecification. American Society of Human
Genetics. October 2018, San Diego.
