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predictiveecology
SpaDES.core:Core Utilities for Developing and Running Spatially Explicit Discrete Event Models
Provides the core framework for a discrete event system to implement a complete data-to-decisions, reproducible workflow. The core components facilitate the development of modular pieces, and enable the user to include additional functionality by running user-built modules. Includes conditional scheduling, restart after interruption, packaging of reusable modules, tools for developing arbitrary automated workflows, automated interweaving of modules of different temporal resolution, and tools for visualizing and understanding the within-project dependencies. The suggested package 'NLMR' can be installed from the repository (<https://PredictiveEcology.r-universe.dev>).
Maintained by Eliot J B McIntire. Last updated 1 months ago.
discrete-events-simulationssimulation-frameworksimulation-modeling
10 stars 10.61 score 142 scripts 6 dependents
bioc
OncoSimulR:Forward Genetic Simulation of Cancer Progression with Epistasis
Functions for forward population genetic simulation in asexual populations, with special focus on cancer progression. Fitness can be an arbitrary function of genetic interactions between multiple genes or modules of genes, including epistasis, order restrictions in mutation accumulation, and order effects. Fitness (including just birth, just death, or both birth and death) can also be a function of the relative and absolute frequencies of other genotypes (i.e., frequency-dependent fitness). Mutation rates can differ between genes, and we can include mutator/antimutator genes (to model mutator phenotypes). Simulating multi-species scenarios and therapeutic interventions, including adaptive therapy, is also possible. Simulations use continuous-time models and can include driver and passenger genes and modules. Also included are functions for: simulating random DAGs of the type found in Oncogenetic Trees, Conjunctive Bayesian Networks, and other cancer progression models; plotting and sampling from single or multiple realizations of the simulations, including single-cell sampling; plotting the parent-child relationships of the clones; generating random fitness landscapes (Rough Mount Fuji, House of Cards, additive, NK, Ising, and Eggbox models) and plotting them.
Maintained by Ramon Diaz-Uriarte. Last updated 28 days ago.
biologicalquestionsomaticmutationcpp
7 stars 6.06 score 68 scriptspredictiveecology
SpaDES.experiment:Simulation Experiments Within The SpaDES Ecosystem
Tools to do simulation experiments within the SpaDES ecosystem. This includes replication, parameter sweeps, scenario analysis, pattern oriented modeling, and simulation experiments. The package introduces a new object class, the simLists, which is an environment that contains many simList class objects. This package also includes tools to do post hoc analyses of such simLists objects.
Maintained by Eliot J B McIntire. Last updated 4 months ago.
1 stars 3.30 score 2 scripts