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ms609
TreeTools:Create, Modify and Analyse Phylogenetic Trees
Efficient implementations of functions for the creation, modification and analysis of phylogenetic trees. Applications include: generation of trees with specified shapes; tree rearrangement; analysis of tree shape; rooting of trees and extraction of subtrees; calculation and depiction of split support; plotting the position of rogue taxa (Klopfstein & Spasojevic 2019) <doi:10.1371/journal.pone.0212942>; calculation of ancestor-descendant relationships, of 'stemwardness' (Asher & Smith, 2022) <doi:10.1093/sysbio/syab072>, and of tree balance (Mir et al. 2013, Lemant et al. 2022) <doi:10.1016/j.mbs.2012.10.005>, <doi:10.1093/sysbio/syac027>; artificial extinction (Asher & Smith, 2022) <doi:10.1093/sysbio/syab072>; import and export of trees from Newick, Nexus (Maddison et al. 1997) <doi:10.1093/sysbio/46.4.590>, and TNT <https://www.lillo.org.ar/phylogeny/tnt/> formats; and analysis of splits and cladistic information.
Maintained by Martin R. Smith. Last updated 8 days ago.
evolutionary-biologyphylogenetic-treesphylogeneticscpp
23 stars 9.83 score 124 scripts 10 dependents
bioc
coMethDMR:Accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies
coMethDMR identifies genomic regions associated with continuous phenotypes by optimally leverages covariations among CpGs within predefined genomic regions. Instead of testing all CpGs within a genomic region, coMethDMR carries out an additional step that selects co-methylated sub-regions first without using any outcome information. Next, coMethDMR tests association between methylation within the sub-region and continuous phenotype using a random coefficient mixed effects model, which models both variations between CpG sites within the region and differential methylation simultaneously.
Maintained by Fernanda Veitzman. Last updated 5 months ago.
dnamethylationepigeneticsmethylationarraydifferentialmethylationgenomewideassociation
7 stars 6.47 score 42 scripts
ctn-0094
public.ctn0094extra:Helper Files for the CTN-0094 Relational Database
Engineered features and "helper" functions ancillary to the 'public.ctn0094data' package, extending this package for ease of use (see <https://CRAN.R-project.org/package=public.ctn0094data>). This 'public.ctn0094data' package contains harmonized datasets from some of the National Institute of Drug Abuse's Clinical Trials Network (NIDA's CTN) projects. Specifically, the CTN-0094 project is to harmonize and de-identify clinical trials data from the CTN-0027, CTN-0030, and CTN-51 studies for opioid use disorder. This current version is built from 'public.ctn0094data' v. 1.0.6.
Maintained by Gabriel Odom. Last updated 1 years ago.
3.88 score 15 scripts