R-universe search: topic:immune-repertoire

Showing 3 of total 3 results (show query)

immunomind

immunarch:Bioinformatics Analysis of T-Cell and B-Cell Immune Repertoires

A comprehensive framework for bioinformatics exploratory analysis of bulk and single-cell T-cell receptor and antibody repertoires. It provides seamless data loading, analysis and visualisation for AIRR (Adaptive Immune Receptor Repertoire) data, both bulk immunosequencing (RepSeq) and single-cell sequencing (scRNAseq). Immunarch implements most of the widely used AIRR analysis methods, such as: clonality analysis, estimation of repertoire similarities in distribution of clonotypes and gene segments, repertoire diversity analysis, annotation of clonotypes using external immune receptor databases and clonotype tracking in vaccination and cancer studies. A successor to our previously published 'tcR' immunoinformatics package (Nazarov 2015) <doi:10.1186/s12859-015-0613-1>.

Maintained by Vadim I. Nazarov. Last updated 1 years ago.

airr-analysis b-cell-receptor bcr bcr-repertoire bioinformatics ig ig-repertoire immune-repertoire immune-repertoire-analysis immune-repertoire-data immunoglobulin immunoinformatics immunology rep-seq repertoire-analysis single-cell single-cell-analysis t-cell-receptor tcr tcr-repertoire cpp

316 stars 9.49 score 203 scripts

qile0317

APackOfTheClones:Visualization of Clonal Expansion for Single Cell Immune Profiles

Visualize clonal expansion via circle-packing. 'APackOfTheClones' extends 'scRepertoire' to produce a publication-ready visualization of clonal expansion at a single cell resolution, by representing expanded clones as differently sized circles. The method was originally implemented by Murray Christian and Ben Murrell in the following immunology study: Ma et al. (2021) <doi:10.1126/sciimmunol.abg6356>.

Maintained by Qile Yang. Last updated 4 months ago.

clonal-analysis immune-repertoire immune-system scrna-seq scrnaseq seurat single-cell single-cell-genomics cpp

15 stars 6.45 score 15 scripts

bioc

IgGeneUsage:Differential gene usage in immune repertoires

Detection of biases in the usage of immunoglobulin (Ig) genes is an important task in immune repertoire profiling. IgGeneUsage detects aberrant Ig gene usage between biological conditions using a probabilistic model which is analyzed computationally by Bayes inference. With this IgGeneUsage also avoids some common problems related to the current practice of null-hypothesis significance testing.

Maintained by Simo Kitanovski. Last updated 5 months ago.

differentialexpression regression genetics bayesian biomedicalinformatics immunooncology mathematicalbiology b-cell-receptor bcr-repertoire differential-analysis differential-gene-expression high-throughput-sequencing immune-repertoire immune-repertoire-analysis immune-repertoires immunogenomics immunoglobulin immunoinformatics immunological-bioinformatics immunology tcr-repertoire vdj-recombination cpp

6 stars 5.92 score 1 scripts