R-universe search: topic:generalised-linear-models

Showing 3 of total 3 results (show query)

bioc

scMET:Bayesian modelling of cell-to-cell DNA methylation heterogeneity

High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task. scMET is a hierarchical Bayesian model which overcomes sparsity, sharing information across cells and genomic features to robustly quantify genuine biological heterogeneity. scMET can identify highly variable features that drive epigenetic heterogeneity, and perform differential methylation and variability analyses. We illustrate how scMET facilitates the characterization of epigenetically distinct cell populations and how it enables the formulation of novel hypotheses on the epigenetic regulation of gene expression.

Maintained by Andreas C. Kapourani. Last updated 5 months ago.

immunooncology dnamethylation differentialmethylation differentialexpression geneexpression generegulation epigenetics genetics clustering featureextraction regression bayesian sequencing coverage singlecell bayesian-inference generalised-linear-models heterogeneity hierarchical-models methylation-analysis single-cell cpp

22 stars 6.27 score 42 scripts

christophergandrud

coreSim:Core Functionality for Simulating Quantities of Interest from Generalised Linear Models

Core functions for simulating quantities of interest from generalised linear models (GLM). This package will form the backbone of a series of other packages that improve the interpretation of GLM estimates.

Maintained by Christopher Gandrud. Last updated 8 years ago.

generalised-linear-models glm simulating-quantities simulation

5 stars 3.88 score 9 scripts 1 dependents

markpurver

biglmm:Bounded Memory Linear and Generalized Linear Models

Regression for data too large to fit in memory. This package functions exactly like the 'biglm' package, but works with later versions of R.

Maintained by Mark Purver. Last updated 5 months ago.

generalised-linear-models fortran

1 stars 2.00 score 6 scripts