ordcrm:Likelihood-Based Continual Reassessment Method (CRM) Dose
Finding Designs
Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose
finding trial and performs simulations to assess design
performance under various scenarios. 3 dose finding designs are
included in this package: ordinal proportional odds model (POM)
CRM, ordinal continuation ratio (CR) model CRM, and the binary
2-parameter logistic model CRM. These functions allow
customization of design characteristics to vary sample size,
cohort sizes, target dose-limiting toxicity (DLT) rates,
discrete or continuous dose levels, combining ordinal grades 0
and 1 into one category, and incorporate safety and/or stopping
rules. For POM and CR model designs, ordinal toxicity grades
are specified by common terminology criteria for adverse events
(CTCAE) version 4.0. Function 'pseudodata' creates the
necessary starting models for these 3 designs, and function
'nextdose' estimates the next dose to test in a cohort of
patients for a target DLT rate. We also provide the function
'crmsimulations' to assess the performance of these 3 dose
finding designs under various scenarios.
