RIbench:Benchmark Suite for Indirect Methods for RI Estimation
The provided benchmark suite enables the automated evaluation and comparison of any existing and novel indirect
method for reference interval ('RI') estimation in a systematic
way. Indirect methods take routine measurements of diagnostic
tests, containing pathological and non-pathological samples as
input and use sophisticated statistical methods to derive a
model describing the distribution of the non-pathological
samples, which can then be used to derive reference intervals.
The benchmark suite contains 5,760 simulated test sets with
varying difficulty. To include any indirect method, a custom
wrapper function needs to be provided. The package offers
functions for generating the test sets, executing the indirect
method and evaluating the results. See ?RIbench or
vignette("RIbench_package") for a more comprehensive
description of the features. A detailed description and
application is described in Ammer T., Schuetzenmeister A.,
Prokosch H.-U., Zierk J., Rank C.M., Rauh M. "RIbench: A
Proposed Benchmark for the Standardized Evaluation of Indirect
Methods for Reference Interval Estimation". Clinical Chemistry
(2022) <doi:10.1093/clinchem/hvac142>.