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rpact-com
rpact:Confirmatory Adaptive Clinical Trial Design and Analysis
Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) <doi:10.1007/978-3-319-32562-0>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.
Maintained by Friedrich Pahlke. Last updated 8 days ago.
adaptive-designanalysisclinical-trialscount-datagroup-sequential-designspower-calculationsample-size-calculationsimulationvalidatedfortrancpp
25 stars 8.20 score 110 scripts 1 dependents
bioc
COTAN:COexpression Tables ANalysis
Statistical and computational method to analyze the co-expression of gene pairs at single cell level. It provides the foundation for single-cell gene interactome analysis. The basic idea is studying the zero UMI counts' distribution instead of focusing on positive counts; this is done with a generalized contingency tables framework. COTAN can effectively assess the correlated or anti-correlated expression of gene pairs. It provides a numerical index related to the correlation and an approximate p-value for the associated independence test. COTAN can also evaluate whether single genes are differentially expressed, scoring them with a newly defined global differentiation index. Moreover, this approach provides ways to plot and cluster genes according to their co-expression pattern with other genes, effectively helping the study of gene interactions and becoming a new tool to identify cell-identity marker genes.
Maintained by Galfrè Silvia Giulia. Last updated 20 days ago.
systemsbiologytranscriptomicsgeneexpressionsinglecell
16 stars 6.85 score 96 scripts