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bioc

openCyto:Hierarchical Gating Pipeline for flow cytometry data

This package is designed to facilitate the automated gating methods in sequential way to mimic the manual gating strategy.

Maintained by Mike Jiang. Last updated 4 days ago.

immunooncologyflowcytometrydataimportpreprocessingdatarepresentationcpp

8.02 score 404 scripts 1 dependents

bioc

flowWorkspace:Infrastructure for representing and interacting with gated and ungated cytometry data sets.

This package is designed to facilitate comparison of automated gating methods against manual gating done in flowJo. This package allows you to import basic flowJo workspaces into BioConductor and replicate the gating from flowJo using the flowCore functionality. Gating hierarchies, groups of samples, compensation, and transformation are performed so that the output matches the flowJo analysis.

Maintained by Greg Finak. Last updated 23 days ago.

immunooncologyflowcytometrydataimportpreprocessingdatarepresentationzlibopenblascpp

7.89 score 576 scripts 10 dependents

bioc

FamAgg:Pedigree Analysis and Familial Aggregation

Framework providing basic pedigree analysis and plotting utilities as well as a variety of methods to evaluate familial aggregation of traits in large pedigrees.

Maintained by Johannes Rainer. Last updated 5 months ago.

geneticspedigree

1 stars 5.26 score 5 scripts

dusadrian

DDIwR:DDI with R

Useful functions for various DDI (Data Documentation Initiative) related inputs and outputs. Converts data files to and from DDI, SPSS, Stata, SAS, R and Excel, including user declared missing values.

Maintained by Adrian Dusa. Last updated 4 months ago.

15 stars 4.92 score 10 scripts

hkgjess

Haplin:Analyzing Case-Parent Triad and/or Case-Control Data with SNP Haplotypes

Performs genetic association analyses of case-parent triad (trio) data with multiple markers. It can also incorporate complete or incomplete control triads, for instance independent control children. Estimation is based on haplotypes, for instance SNP haplotypes, even though phase is not known from the genetic data. 'Haplin' estimates relative risk (RR + conf.int.) and p-value associated with each haplotype. It uses maximum likelihood estimation to make optimal use of data from triads with missing genotypic data, for instance if some SNPs has not been typed for some individuals. 'Haplin' also allows estimation of effects of maternal haplotypes and parent-of-origin effects, particularly appropriate in perinatal epidemiology. 'Haplin' allows special models, like X-inactivation, to be fitted on the X-chromosome. A GxE analysis allows testing interactions between environment and all estimated genetic effects. The models were originally described in "Gjessing HK and Lie RT. Case-parent triads: Estimating single- and double-dose effects of fetal and maternal disease gene haplotypes. Annals of Human Genetics (2006) 70, pp. 382-396".

Maintained by Hakon K. Gjessing. Last updated 7 months ago.

cpp

3 stars 4.87 score 49 scripts

cran

bartMan:Create Visualisations for BART Models

Investigating and visualising Bayesian Additive Regression Tree (BART) (Chipman, H. A., George, E. I., & McCulloch, R. E. 2010) <doi:10.1214/09-AOAS285> model fits. We construct conventional plots to analyze a model’s performance and stability as well as create new tree-based plots to analyze variable importance, interaction, and tree structure. We employ Value Suppressing Uncertainty Palettes (VSUP) to construct heatmaps that display variable importance and interactions jointly using colour scale to represent posterior uncertainty. Our visualisations are designed to work with the most popular BART R packages available, namely 'BART' Rodney Sparapani and Charles Spanbauer and Robert McCulloch 2021 <doi:10.18637/jss.v097.i01>, 'dbarts' (Vincent Dorie 2023) <https://CRAN.R-project.org/package=dbarts>, and 'bartMachine' (Adam Kapelner and Justin Bleich 2016) <doi:10.18637/jss.v070.i04>.

Maintained by Alan Inglis. Last updated 8 months ago.

openjdk

2.00 score

sophiekersting

treeDbalance:Computation of 3D Tree Imbalance

The main goal of the R package 'treeDbalance' is to provide functions for the computation of several measurements of 3D node imbalance and their respective 3D tree imbalance indices, as well as to introduce the new 'phylo3D' format for rooted 3D tree objects. Moreover, it encompasses an example dataset of 3D models of 63 beans in 'phylo3D' format. Please note that this R package was developed alongside the project described in the manuscript 'Measuring 3D tree imbalance of plant models using graph-theoretical approaches' by M. Fischer, S. Kersting, and L. Kühn (2023) <arXiv:2307.14537>, which provides precise mathematical definitions of the measurements. Furthermore, the package contains several helpful functions, for example, some auxiliary functions for computing the ancestors, descendants, and depths of the nodes, which ensures that the computations can be done in linear time. Most functions of 'treeDbalance' require as input a rooted tree in the 'phylo3D' format, an extended 'phylo' format (as introduced in the R package 'ape' 1.9 in November 2006). Such a 'phylo3D' object must have at least two new attributes next to those required by the 'phylo' format: 'node.coord', the coordinates of the nodes, as well as 'edge.weight', the literal weight or volume of the edges. Optional attributes are 'edge.diam', the diameter of the edges, and 'edge.length', the length of the edges. For visualization purposes one can also specify 'edge.type', which ranges from normal cylinder to bud to leaf, as well as 'edge.color' to change the color of the edge depiction. This project was supported by the joint research project DIG-IT! funded by the European Social Fund (ESF), reference: ESF/14-BM-A55-0017/19, and the Ministry of Education, Science and Culture of Mecklenburg-Western Pomerania, Germany, as well as by the the project ArtIGROW, which is a part of the WIR!-Alliance 'ArtIFARM – Artificial Intelligence in Farming' funded by the German Federal Ministry of Education and Research (FKZ: 03WIR4805).

Maintained by Sophie Kersting. Last updated 2 years ago.

1.00 score

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