wnl:Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
Analysis
This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the
Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and
Pharmacodynamic Data Analysis - Concepts and Applications" 5th
ed. (ISBN:9198299107). Examples include linear and nonlinear
compartmental model, turn-over model, single or multiple dosing
bolus/infusion/oral models, allometry, toxicokinetics,
reversible metabolism, in-vitro/in-vivo extrapolation,
enterohepatic circulation, metabolite modeling, Emax model,
inhibitory model, tolerance model, oscillating response model,
enantiomer interaction model, effect compartment model,
drug-drug interaction model, receptor occupancy model, and
rebound phenomena model.
