Showing 77 of total 77 results (show query)

bioc

Moonlight2R:Identify oncogenes and tumor suppressor genes from omics data

The understanding of cancer mechanism requires the identification of genes playing a role in the development of the pathology and the characterization of their role (notably oncogenes and tumor suppressors). We present an updated version of the R/bioconductor package called MoonlightR, namely Moonlight2R, which returns a list of candidate driver genes for specific cancer types on the basis of omics data integration. The Moonlight framework contains a primary layer where gene expression data and information about biological processes are integrated to predict genes called oncogenic mediators, divided into putative tumor suppressors and putative oncogenes. This is done through functional enrichment analyses, gene regulatory networks and upstream regulator analyses to score the importance of well-known biological processes with respect to the studied cancer type. By evaluating the effect of the oncogenic mediators on biological processes or through random forests, the primary layer predicts two putative roles for the oncogenic mediators: i) tumor suppressor genes (TSGs) and ii) oncogenes (OCGs). As gene expression data alone is not enough to explain the deregulation of the genes, a second layer of evidence is needed. We have automated the integration of a secondary mutational layer through new functionalities in Moonlight2R. These functionalities analyze mutations in the cancer cohort and classifies these into driver and passenger mutations using the driver mutation prediction tool, CScape-somatic. Those oncogenic mediators with at least one driver mutation are retained as the driver genes. As a consequence, this methodology does not only identify genes playing a dual role (e.g. TSG in one cancer type and OCG in another) but also helps in elucidating the biological processes underlying their specific roles. In particular, Moonlight2R can be used to discover OCGs and TSGs in the same cancer type. This may for instance help in answering the question whether some genes change role between early stages (I, II) and late stages (III, IV). In the future, this analysis could be useful to determine the causes of different resistances to chemotherapeutic treatments. An additional mechanistic layer evaluates if there are mutations affecting the protein stability of the transcription factors (TFs) of the TSGs and OCGs, as that may have an effect on the expression of the genes.

Maintained by Matteo Tiberti. Last updated 2 months ago.

dnamethylationdifferentialmethylationgeneregulationgeneexpressionmethylationarraydifferentialexpressionpathwaysnetworksurvivalgenesetenrichmentnetworkenrichment

5 stars 6.41 score 43 scripts

inbo

INBOmd:Markdown Templates for INBO

Several templates to generate reports, presentations and posters.

Maintained by Thierry Onkelinx. Last updated 1 years ago.

bookdownrmarkdownxelatex

12 stars 4.52 score 11 scripts

openvolley

volleyreport:Reports from Volleyball Match Files

Functions for generating reports from volleyball match files.

Maintained by Adrien Ickowicz. Last updated 4 months ago.

3 stars 3.84 score 19 scripts 1 dependents

openvolley

ovscout2:An R Shiny App for Scouting Volleyball Match Files

Functions for scouting volleyball match files.

Maintained by Ben Raymond. Last updated 11 months ago.

6 stars 3.78 score 8 scripts

pakillo

ANECAtools:Facilitando el proceso de acreditación en la ANECA

Herramientas para facilitar el proceso de solicitud de acreditación de profesorado en la ANECA.

Maintained by Francisco Rodríguez-Sánchez. Last updated 1 months ago.

20 stars 3.30 score 3 scripts

trevorld

pnpmisc:Utilities for Print-and-Play Board Games

Utilities for print-and-play board games.

Maintained by Trevor L. Davis. Last updated 25 days ago.

print-and-play

3.02 score 1 dependents

nenuial

geovizr:Support for Knitr (Quarto/Rmd)

Provide support functions for Quarto and Rmd documents.

Maintained by Pascal Burkhard. Last updated 1 months ago.

2.60 score 3 scripts

bristol-vaccine-centre

avoncap:AvonCap Study Analysis

A WIP set of functions allowing data load, wrangling of the AvonCap data set.

Maintained by Rob Challen. Last updated 4 months ago.

2.34 score 11 scripts

trevorld

sbgjackets:Utilities for Small Box Game Jackets

Utilities for small box game jackets.

Maintained by Trevor L. Davis. Last updated 16 days ago.

print-and-play

2.30 score

carlosyanez

customthemes:custom theming for ggplot, for personal use

Collection of (ggplot) theming options for personal use.

Maintained by Carlos Yanez Santibanez. Last updated 3 years ago.

1 stars 1.70 score 1 scripts

cran

MiRNAQCD:Micro-RNA Quality Control and Diagnosis

A complete and dedicated analytical toolbox for quality control and diagnosis based on subject-related measurements of micro-RNA (miRNA) expressions. The package consists of a set of functions that allow to train, optimize and use a Bayesian classifier that relies on multiplets of measured miRNA expressions. The package also implements the quality control tools required to preprocess input datasets. In addition, the package provides a function to carry out a statistical analysis of miRNA expressions, which can give insights to improve the classifier's performance. The method implemented in the package was first introduced in L. Ricci, V. Del Vescovo, C. Cantaloni, M. Grasso, M. Barbareschi and M. A. Denti, "Statistical analysis of a Bayesian classifier based on the expression of miRNAs", BMC Bioinformatics 16:287, 2015 <doi:10.1186/s12859-015-0715-9>. The package is thoroughly described in M. Castelluzzo, A. Perinelli, S. Detassis, M. A. Denti and L. Ricci, "MiRNA-QC-and-Diagnosis: An R package for diagnosis based on MiRNA expression", SoftwareX 12:100569, 2020 <doi:10.1016/j.softx.2020.100569>. Please cite both these works if you use the package for your analysis. DISCLAIMER: The software in this package is for general research purposes only and is thus provided WITHOUT ANY WARRANTY. It is NOT intended to form the basis of clinical decisions. Please refer to the GNU General Public License 3.0 (GPLv3) for further information.

Maintained by Alessio Perinelli. Last updated 2 years ago.

1.00 score