R-universe search: needs:distillery

Showing 7 of total 7 results (show query)

bioc

scde:Single Cell Differential Expression

The scde package implements a set of statistical methods for analyzing single-cell RNA-seq data. scde fits individual error models for single-cell RNA-seq measurements. These models can then be used for assessment of differential expression between groups of cells, as well as other types of analysis. The scde package also contains the pagoda framework which applies pathway and gene set overdispersion analysis to identify and characterize putative cell subpopulations based on transcriptional signatures. The overall approach to the differential expression analysis is detailed in the following publication: "Bayesian approach to single-cell differential expression analysis" (Kharchenko PV, Silberstein L, Scadden DT, Nature Methods, doi: 10.1038/nmeth.2967). The overall approach to subpopulation identification and characterization is detailed in the following pre-print: "Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis" (Fan J, Salathia N, Liu R, Kaeser G, Yung Y, Herman J, Kaper F, Fan JB, Zhang K, Chun J, and Kharchenko PV, Nature Methods, doi:10.1038/nmeth.3734).

Maintained by Evan Biederstedt. Last updated 5 months ago.

immunooncology rnaseq statisticalmethod differentialexpression bayesian transcription software analysis bioinformatics heterogenity ngs single-cell transcriptomics openblas cpp openmp

173 stars 7.53 score 141 scripts

brry

extremeStat:Extreme Value Statistics and Quantile Estimation

Fit, plot and compare several (extreme value) distribution functions. Compute (truncated) distribution quantile estimates and plot return periods on a linear scale. On the fitting method, see Asquith (2011): Distributional Analysis with L-moment Statistics [...] ISBN 1463508417.

Maintained by Berry Boessenkool. Last updated 1 years ago.

14 stars 5.88 score 36 scripts 1 dependents

davidvandijcke

DiSCos:Distributional Synthetic Controls Estimation

The method of synthetic controls is a widely-adopted tool for evaluating causal effects of policy changes in settings with observational data. In many settings where it is applicable, researchers want to identify causal effects of policy changes on a treated unit at an aggregate level while having access to data at a finer granularity. This package implements a simple extension of the synthetic controls estimator, developed in Gunsilius (2023) <doi:10.3982/ECTA18260>, that takes advantage of this additional structure and provides nonparametric estimates of the heterogeneity within the aggregate unit. The idea is to replicate the quantile function associated with the treated unit by a weighted average of quantile functions of the control units. The package contains tools for aggregating and plotting the resulting distributional estimates, as well as for carrying out inference on them.

Maintained by David Van Dijcke. Last updated 17 days ago.

1 stars 4.81 score 8 scripts

cran

extRemes:Extreme Value Analysis

General functions for performing extreme value analysis. In particular, allows for inclusion of covariates into the parameters of the extreme-value distributions, as well as estimation through MLE, L-moments, generalized (penalized) MLE (GMLE), as well as Bayes. Inference methods include parametric normal approximation, profile-likelihood, Bayes, and bootstrapping. Some bivariate functionality and dependence checking (e.g., auto-tail dependence function plot, extremal index estimation) is also included. For a tutorial, see Gilleland and Katz (2016) <doi: 10.18637/jss.v072.i08> and for bootstrapping, please see Gilleland (2020) <doi: 10.1175/JTECH-D-20-0070.1>.

Maintained by Eric Gilleland. Last updated 4 months ago.

2 stars 3.81 score 5 dependents

paciorek

climextRemes:Tools for Analyzing Climate Extremes

Functions for fitting GEV and POT (via point process fitting) models for extremes in climate data, providing return values, return probabilities, and return periods for stationary and nonstationary models. Also provides differences in return values and differences in log return probabilities for contrasts of covariate values. Functions for estimating risk ratios for event attribution analyses, including uncertainty. Under the hood, many of the functions use functions from 'extRemes', including for fitting the statistical models. Details are given in Paciorek, Stone, and Wehner (2018) <doi:10.1016/j.wace.2018.01.002>.

Maintained by Christopher Paciorek. Last updated 1 years ago.

2.85 score 14 scripts

ericgilleland

in2extRemes:Into the extRemes Package

Graphical User Interface (GUI) to some of the functions in the package extRemes version >= 2.0 are included.

Maintained by Eric Gilleland. Last updated 8 years ago.

1.00 score 2 scripts

cran

SpatialVx:Spatial Forecast Verification

Spatial forecast verification refers to verifying weather forecasts when the verification set (forecast and observations) is on a spatial field, usually a high-resolution gridded spatial field. Most of the functions here require the forecast and observed fields to be gridded and on the same grid. For a thorough review of most of the methods in this package, please see Gilleland et al. (2009) <doi: 10.1175/2009WAF2222269.1> and for a tutorial on some of the main functions available here, see Gilleland (2022) <doi: 10.5065/4px3-5a05>.

Maintained by Eric Gilleland. Last updated 4 months ago.

1 stars 1.00 score